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Overexpression of nicotinamide mononucleotide adenylyltransferase (nmnat) increases the growth rate, Ca2+ concentration and cellulase production in Ganoderma lucidum
AbstractIdentifying new and economical means to utilize diverse lignocellulosic biomass is an urgent task. Ganoderma lucidum is a well-known edible...
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The Potential of Synthetic Biology for Trichoderma reesei
Within the last 20 years, ground-breaking progress has been made in the field of synthetic biology, enabling the construction of novel pathways up to...
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Involvement of Xyr1 and Are1 for Trichodermapepsin Gene Expression in Response to Cellulose and Galactose in Trichoderma reesei
The secretome of Trichoderma reesei contains a mixture of cellulases, hemicellulases, amylases, proteases, and lipases that synergistically degrade...
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Protein structure analysis of the interactions between SARS-CoV-2 spike protein and the human ACE2 receptor: from conformational changes to novel neutralizing antibodies
The recent severe acute respiratory syndrome, known as Coronavirus Disease 2019 (COVID-19) has spread so much rapidly and severely to induce World...
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Antifungal Secondary Metabolites Against Blast Fungus Magnaporthe oryzae
Magnaporthe oryzae is one of the most destructive fungal pathogen causing blast diseases in at least 50 grass species including wheat and rice....
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Nonsense-mediated mRNA decay and metal ion homeostasis and detoxification in Saccharomyces cerevisiae
The highly conserved Nonsense-mediated mRNA decay (NMD) pathway is a translation dependent mRNA degradation pathway. Although NMD is best known for...
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Genus level analysis of PKS-NRPS and NRPS-PKS hybrids reveals their origin in Aspergilli
BackgroundFilamentous fungi produce a vast amount of bioactive secondary metabolites (SMs) synthesized by e.g. hybrid polyketide...
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Molecular docking studies of Indian variants of pathophysiological proteins of SARS-CoV-2 with selected drug candidates
SARS-CoV-2 pandemic has recently made the entire world come to a standstill. The number of cases in the world, especially India, have been increasing...
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Protein secretion and associated stress in industrially employed filamentous fungi
AbstractApplication of filamentous fungi for the production of commercial enzymes such as amylase, cellulase, or xylanase is on the rise due to the...
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Proposed Mechanisms of Targeting COVID-19 by Delivering Mesenchymal Stem Cells and Their Exosomes to Damaged Organs
With the outbreak of coronavirus disease (COVID-19) caused by novel severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the world has been...
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The essential liaison of two copper proteins: the Cu-sensing transcription factor Mac1 and the Cu/Zn superoxide dismutase Sod1 in Saccharomyces cerevisiae
Although copper is an essential trace element for cell function and viability, its excess can lead to protein oxidation, DNA cleavage, and ultimate...
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Mechanistic Insight into the role of Vitamin D and Zinc in Modulating Immunity Against COVID-19: A View from an Immunological Standpoint
The pathophysiology of coronavirus disease-19 (COVID-19) is characterized by worsened inflammation because of weakened immunity, causing the...
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Utilizing Host-Plant Resistance to Circumvent Blast Disease in Rice
Blast is one of the devastating diseases of rice which cause significant yield losses. Blast is mainly managed by the use of fungicides. However,...
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Identification of candidate genes and favourable haplotypes for yield traits in rice based on a genome-wide association study
The key to food security is increasing rice yield. Therefore, we performed a genome-wide association study (GWAS) to analyse and identify the effects...
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Whole-body transcriptome mining for candidate effectors from Diuraphis noxia
BackgroundProteins within aphid saliva play a crucial role as the molecular interface between aphids and their host plants. These salivary effectors...
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Combined strategy of transcription factor manipulation and β-glucosidase gene overexpression in Trichoderma reesei and its application in lignocellulose bioconversion
The industrial application of Trichoderma reesei has been greatly limited by insufficient β-glucosidase activity in its cellulase system. In this...
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Breeding and Omics Approaches to Understand Abiotic Stress Response in Rice
Rice (Oryza sativa L.) is the major sources of food and calories for more than half of the world population. Productivity of rice is adversely...
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Repurposing of RAS-Pathway Mediated Drugs for Intestinal Inflammation Related Diseases for Treating SARS-CoV-2 Infection
Severe Acute Respiratory Syndrome coronavirus 2 (SARS-CoV-2) is an emerging zoonotic virus, which causes Coronavirus Disease 2019 (COVID-19). Entry...
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Evolution of different rice ecotypes and genetic basis of flooding adaptability in Deepwater rice by GWAS
BackgroundRice is the world’s second largest food crop and accelerated global climate change due to the intensification of human activities has a...
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Whole transcriptomic analysis reveals overexpression of salivary gland and cuticular proteins genes in insecticide-resistant Anopheles arabiensis from Western Kenya
BackgroundEffective vector control is key to malaria prevention. However, this is now compromised by increased insecticide resistance due to...
