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Structural features of cysteine-rich polypeptides from sea anemone venoms
At present, the discovery of drugs based on animal venoms undergoes its rebirth: pharmaceutical companies start to accept gradually the potential of...
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Evidence for role of acid-sensing ion channels in nucleus ambiguus neurons: essential differences in anesthetized versus awake rats
Acid-sensing ion channels (ASIC) are widely expressed in several brain regions including medulla; their role in physiology and pathophysiology is...
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The comprehensive analysis of DEG/ENaC subunits in Hydrareveals a large variety of peptide-gated channels, potentially involved in neuromuscular transmission
BackgroundIt is generally the case that fast transmission at neural synapses is mediated by small molecule neurotransmitters. The simple nervous...
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Acidotoxicity and acid-sensing ion channels contribute to motoneuron degeneration
Amyotrophic lateral sclerosis (ALS) is a fatal neurological condition with no cure. Mitochondrial dysfunction, Ca 2+ overloading and local...
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Advanced Type 1 Diabetes is Associated with ASIC Alterations in Mouse Lower Thoracic Dorsal Root Ganglia Neurons
Acid-sensing ion channels (ASICs) from dorsal root ganglia (DRG) neurons are proton sensors during ischemia and inflammation. Little is known about...
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Neurotrophin signaling and visceral hypersensitivity
Neurotrophin family are traditionally recognized for their nerve growth promoting function and are recently identified as crucial factors in...
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Spider Venom Components as Drug Candidates
Animal venoms represent a rich resource of bioactive molecules. These complex biofluids contain a multitude of proteins, peptides and small molecules...
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The Neurotoxic Mode of Action of Venoms from the Spider Family Theraphosidae
Spiders from the family Theraphosidae are typically generalist predators of both invertebrates and vertebrates. Due to their large size and...
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A sea anemone polypeptide toxin inhibiting the ASIC3 acid-sensitive channel
A polypeptide toxin π-AnmTX Hcr 1b-1 with a molecular mass of 4537 Da was isolated from the whole extract of the sea anemone Heteractis crispa by...
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Membrankanäle und -pumpen
Die Lipiddoppelschicht biologischer Membranen ist von sich aus für Ionen und polare Moleküle impermeabel. Eine gewisse Durchlässigkeit für diese...
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Molecular and functional identification of sodium channels in K562 cells
Modulations of ion channel activity underlie rapid changes in membrane transport of cations in various nonexcitable cells. Previously, in smooth...
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Deciphering microRNA code in pain and inflammation: lessons from bladder pain syndrome
MicroRNAs (miRNAs), a novel class of molecules regulating gene expression, have been hailed as modulators of many biological processes and disease...
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Acid-sensing ion channel 1a mediates acid-induced increases in intracellular calcium in rat articular chondrocytes
Acid-sensing ion channels (ASICs) are cationic channels that are activated by extracellular acidification and implicated in pain perception, ischemic...
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Ion channels in neuronal survival
The study of ion channels represents one of the most active fields in neuroscience research in China. In the last 10 years, active research in...
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Acid-sensing ion channels 3: a potential therapeutic target for pain treatment in arthritis
Acid-sensing ion channels 3 (ASIC3) is the most sensitive to such a pH change, predominantly distributed in the sensory peripheral nervous system,...
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Role of acidosis, NMDA receptors, and acid-sensitive ion channel 1a (ASIC1a) in neuronal death induced by ischemia
This review collects data on the influence of intracellular and extracellular acidosis on neuronal viability and the effect of acidosis on neuronal...
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Pain research in China
In addition to investigating the anatomy, neurochemistry and neurophysiology of pain pathways, Chinese researchers have extended their work into the...