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1. Methamphetamine-induced changes in myocardial gene transcription are sex-dependent

   Background

   Prior work demonstrated that female rats (but not their male littermates) exposed to methamphetamine become hypersensitive to myocardial...

   Hasitha Chavva, Daniel A. Brazeau, ... Boyd R. Rorabaugh in BMC Genomics

   Article Open access 12 April 2021
   

2. Extracellular RNA in renal diseases

   The discovery of extracellular RNA (exRNA) in blood and bodily fluids has expended our knowledge on RNA functions. ExRNAs may be transferred between...

   Yang Zhou, Junwei Yang in ExRNA

   Article Open access 14 February 2019

3. The critical role of the interplays of EphrinB2/EphB4 and VEGF in the induction of angiogenesis

   The significant role of VEGF (vascular endothelial growth factor) as an angiogenesis inducer is well recognized. Besides VEGF, EphrinB2/EphB4 also...

   Enming Du, Xue Li, ... Shikun He in Molecular Biology Reports

   Article 02 June 2020
   

4. Mutational screening of PKD2 gene in the north Indian polycystic kidney disease patients revealed 28 genetic variations

   Polycystic kidney disease (PKD) is a systemic disorder which adds majority of renal patients to end stage renal disease. Autosomal dominant...

   Sonam Raj, Rana Gopal Singh, Parimal Das in Journal of Genetics

   Article 27 September 2017
   

5. A role for polycystin-1 and polycystin-2 in neural progenitor cell differentiation

   Polycystin-1 (PC1) and polycystin-2 (PC2) are transmembrane proteins encoded by the Pkd1 and Pkd2 genes, respectively. Mutations in these genes are...

   Natalie Winokurow, Stefan Schumacher in Cellular and Molecular Life Sciences

   Article 20 March 2019
   

6. Human reconstructed kidney models

   The human kidney, which consists of up to 2 million nephrons, is critical for blood filtration, electrolyte balance, pH regulation, and fluid balance...

   Seiji Kishi, Takuya Matsumoto, ... Craig R. Brooks in In Vitro Cellular & Developmental Biology - Animal

   Article 16 February 2021
   

7. Mitochondrial microRNA (MitomiRs) in cancer and complex mitochondrial diseases: current status and future perspectives

   Mitochondria are not only important for cellular bioenergetics but also lie at the heart of critical metabolic pathways. They can rapidly adjust...

   Paresh Kumar Purohit, Neeru Saini in Cellular and Molecular Life Sciences

   Article 21 October 2020
   

8. Transient Receptor Potential (TRP) Channels

   Transient Receptor Potential (TRP) channels are evolutionarily conserved integral membrane proteins. The mammalian TRP superfamily of ion channels...

   Amrita Samanta, Taylor E. T. Hughes, Vera Y. Moiseenkova-Bell in Membrane Protein Complexes: Structure and Function

   Chapter 2018
   

9. Mass Spectrometry-Based Analysis of TRPP2 Phosphorylation

   Differential phosphorylation of proteins is a key regulatory mechanism in biology. Immunoprecipitation-coupled mass spectrometry facilitates the...

   Verónica I. Dumit, Michael Köttgen, Alexis Hofherr in TRP Channels

   Protocol 2019
   

10. Metabolic perturbations caused by depletion of nephronophthisis factor Anks6 in mIMCD3 cells

    Introduction

    Nephronophthisis (NPH) is an inherited form of cystic kidney disease with various extrarenal manifestations accounting for the largest...

    Manuel Schlimpert, Simon Lagies, ... Bernd Kammerer in Metabolomics

    Article 30 April 2019
    

11. Implications of microRNA in kidney metabolic disorders

    The kidney requires large amount of energy to regulate the balance of fluid, electrolytes and acid-base homeostasis. Mitochondria provide...

    Yang Zhou, Junwei Yang in ExRNA

    Article Open access 10 February 2020
    

12. Zebrafish heart failure models: opportunities and challenges

    Heart failure is a complex pathophysiological syndrome of pum** functional failure that results from injury, infection or toxin-induced damage on...

    **ngjuan Shi, Ru Chen, ... **ao-Yan Wen in Amino Acids

    Article 03 May 2018
    

13. Structure of the polycystic kidney disease TRP channel Polycystin-2 (PC2)

    Mutations in either polycystin-1 (PC1 or PKD1) or polycystin-2 (PC2, PKD2 or TRPP1) cause autosomal-dominant polycystic kidney disease (ADPKD)...

    Mariana Grieben, Ashley C W Pike, ... Elisabeth P Carpenter in Nature Structural & Molecular Biology

    Article 19 December 2016
    

14. Organellar TRP channels

    Mammalian transient receptor potential (TRP) channels mediate Ca ²⁺ flux and voltage changes across membranes in response to environmental and...

    **aoli Zhang, Meiqin Hu, ... Haoxing Xu in Nature Structural & Molecular Biology

    Article 29 October 2018
    

15. Ouabain Regulates CFTR-Mediated Anion Secretion and Na,K-ATPase Transport in ADPKD Cells

    Cyst enlargement in autosomal dominant polycystic kidney disease (ADPKD) requires the transepithelial secretion of fluid into the cyst lumen. We...

    Kyle Jansson, Jessica Venugopal, ... Gustavo Blanco in The Journal of Membrane Biology

    Article 20 August 2015
    

16. Stem cell-derived kidney organoids: engineering the vasculature

    Kidney organoids can be generated from human pluripotent stem cells (PSCs) using protocols that resemble the embryonic development of the kidney. The...

    Marije Koning, Cathelijne W. van den Berg, Ton J. Rabelink in Cellular and Molecular Life Sciences

    Article Open access 05 December 2019
    

17. Inflammation and Fibrosis in Polycystic Kidney Disease

    Polycystic kidney disease (PKD) is a commonly inherited disorder characterized by cyst formation and fibrosis (Wilson, N Engl J Med 350:151–164,...

    Cheng Jack Song, Kurt A. Zimmerman, ... Bradley K. Yoder in Kidney Development and Disease

    Chapter 2017
    

18. Quantification of angiotensin II-regulated proteins in urine of patients with polycystic and other chronic kidney diseases by selected reaction monitoring

    Background

    Angiotensin-II (Ang II) mediates progression of autosomal-dominant polycystic kidney disease (ADPKD) and other chronic kidney diseases...

    Ana Konvalinka, Ihor Batruch, ... James W. Scholey in Clinical Proteomics

    Article Open access 05 August 2016
    

19. Chronic exposure to ethylenethiourea induces kidney injury and polycystic kidney in mice

    Backgrounds

    Ethylenethiourea (ETU) is one of the main metabolite of ethylenebisdithiocarbamate fungicides and potential exposure is highest for...

    Hwa-Kyoung Chung, Won-Chul Cho, ... Byong-Gon Park in Molecular & Cellular Toxicology

    Article 28 December 2018

20. Erythrocyte glutathione transferase in kidney transplantation: a probe for kidney detoxification efficiency

    Erythrocyte glutathione transferase (e-GST) is overexpressed in case of increased blood toxicity and its level correlates with the kidney disease...

    Alessio Bocedi, Annalisa Noce, ... Giorgio Ricci in Cell Death & Disease

    Article Open access 19 February 2018