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Strain-specific behavior of Mycobacterium tuberculosis in A549 lung cancer cell line
BackgroundA growing body of evidence has shown the association between tuberculosis (TB) infection and lung cancer. However, the possible effect of...
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Hypoxia Potentiated Lung Cancer Cell Migration and Invasion by up-regulating HIF1α/JAK2/STAT3 Axis and Activating MMP13 Transcription
Excessive aggressive migration and invasion are important factors that increase the mortality of cancer patients. Matrix metalloproteinase 13 (MMP13)...
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Andrographis modulates cisplatin resistance in lung cancer via miR-155-5p/SIRT1 axis
Andrographis (Andro) has been identified as an anti-cancer herbal. This study was to explore its underlying regulatory routes regarding cisplatin...
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Inhibition of autophagy potentiates the cytotoxicity of the irreversible FGFR1-4 inhibitor FIIN-2 on lung adenocarcinoma
For patients with platinum-resistant lung adenocarcinoma (LUAD), the exploration of new effective drug candidates is urgently needed. Fibroblast...
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Design, synthesis and biological evaluation of 5H-[1,2,4]triazino[5,6-b]indole derivatives bearing a pyridinocycloalkyl moiety as iron chelators
The avidity of cancer cells for iron highlights the potential for iron chelators to be used in cancer therapy. Herein, we designed and synthesized a...
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Biological assessment of new tetrahydroacridine derivatives with fluorobenzoic moiety in vitro on A549 and HT-29 cell lines and in vivo on animal model
A new series of tetrahydroacridine derivatives with the fluorobenzoyl moiety was synthesized and evaluated for cytotoxic activity against lung cancer...
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Sohlh2 promotes pulmonary fibrosis via repression of p62/Keap1/Nrf2 mediated anti-oxidative signaling pathway
Disturbance in the redox balance of alveolar epithelial cells (AECs) was considered as a causal factor for pulmonary fibrosis. The regulatory...
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Signal Transducer and Activator of Transcription 4-Induced Up-Regulated LINC01278 Enhances Proliferation and Invasion of Non-Small Cell Lung Cancer Cells via the MicroRNA-877-5p/Activating Transcription Factor 4 Axis
Background:The purpose of this study was to investigate the specific effects of signal transducer and activator of transcription 4 (STAT4)-induced...
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Suppression of the Expression of Molecular Chaperones as a Factor in Increasing the Efficiency of Antitumor Therapy
AbstractModern methods of antitumor chemotherapy are not able to destroy 100% of the cell population. The use of modern methods of chemotherapy is...
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Determining the Importance of Peroxisomal Proteins for Viral Infections in Cultured Mammalian Cells
Peroxisomes have recently been shown to play important roles in the context of viral infections. However, further and more detailed studies should be...
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Nuclear protein NOP2 serves as a poor-prognosis predictor of LUAD and aggravates the malignancy of lung adenocarcinoma cells
Recent studies have shown that NOP2, a nucleolar protein, is up-regulated in various cancers, suggesting a potential link to tumor aggressiveness and...
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Heat-Killed Lactilactobacillus sakei WB2305 and Lactiplantibacillus plantarum WB2324 Inhibited LPS-Induced Inflammation in Human Airway Epithelial Cells
Asthma is characterized by inflammation of the airways, including the inflammatory and airway structural cells. Probiotics, which have diverse...
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RPL11 promotes non-small cell lung cancer cell proliferation by regulating endoplasmic reticulum stress and cell autophagy
BackgroundAbnormal biogenesis and ribosome free function of ribosomal proteins (RPs) is important for tumorgenesis and development. Ribosomal protein...
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Paralemnalia thyrsoides-associated fungi: phylogenetic diversity, cytotoxic potential, metabolomic profiling and docking analysis
BackgroundCancer continues to be one of the biggest causes of death that affects human health. Chemical resistance is still a problem in conventional...
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Simple chitin-based cell culture platform for production of biopharmaceuticals
ObjectivesGene therapy using viral vectors and antibody-based therapies continue to expand within the pharmaceutical market. We evaluated whether...
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SMYD3 regulates the abnormal proliferation of non-small-cell lung cancer cells via the H3K4me3/ANO1 axis
Non-small-cell lung cancer (NSCLC) is the most prevalent type of lung cancer. This study evaluated the mechanism of histone methyltransferase SET and...
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Elevated HMGB1 promotes the malignant progression and contributes to cisplatin resistance of non-small cell lung cancer
BackgroundHMGB1 (high mobility group box B-1) exhibits crucial role in tumor genesis and development, including lung cancer. Whereas, more...
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Effect of Focal Adhesion Kinase and Vinculin Expression on Migration Parameters of Normal and Tumor Epitheliocytes
AbstractFocal adhesions (FAs) are mechanosensory structures that transform physical stimuli into chemical signals guiding cell migration....
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Investigating the chemo-preventive role of noscapine in lung carcinoma via therapeutic targeting of human aurora kinase B
Lung carcinoma is the major contributor to global cancer incidence and one of the leading causes of cancer-related mortality worldwide....
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p53 regulates lysosomal membrane permeabilization as well as cytoprotective autophagy in response to DNA-damaging drugs
Lysosomes are single-membraned organelles that mediate the intracellular degradation of macromolecules. Various stress can induce lysosomal membrane...
