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Recent advances in understanding the roles of sialyltransferases in tumor angiogenesis and metastasis
Abnormal glycosylation is a common characteristic of cancer cells and there is a lot of evidence that glycans can regulate the biological behavior of...
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Quantification of Leukocyte–Endothelial Cell Interaction During In Vitro Models of Thrombosis at Arterial and Venous Shear Rates
Upon injury, stable thrombi formation requires the recruitment of platelets, leukocytes, and various clotting factors, to provide sufficient...
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Cytokine Therapy
Cytokine therapy repairs the damaged heart after AMI. Cytokines that repair the damaged heart are G-CSF and erythropoietin. Post-infarct subcutaneous...
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Cholesteryl α-D-glucoside 6-acyltransferase enhances the adhesion of Helicobacter pylori to gastric epithelium
Helicobacter pylori , the most common etiologic agent of gastric diseases including gastric cancer, is auxotrophic for cholesterol and has to hijack...
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Helicobacter pylori in the post-antibiotics era: from virulence factors to new drug targets and therapeutic agents
Helicobacter pylori is considered one of the most prevalent human pathogenic microbes globally. It is the main cause of a number of gastrointestinal...
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Carbohydrate Systems in Targeted Drug Delivery: Expectation and Reality
AbstractIn the end of the twentieth century, the world entered the era of high-tech and personalized medicine, characterized by the introduction of...
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DC-SIGNs
Among the PRRs, the DC-SIGN (CD209) directly involves in diverse molecular events in the interaction of DCs with some pathogens. DC-SIGN as a TM...
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The Role of Glycosylation in Infectious Diseases
Glycosylation plays an important role in infectious diseases. Many important interactions between pathogens and hosts involve their carbohydrate...
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Identification of potential biomarkers for melanoma cancer (black tumor) using bioinformatics strategy: a study based on GEO and SRA datasets
Melanoma, a highly invasive type of skin cancer that penetrates the entire dermis layer, is associated with increased mortality rates. Excessive...
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Mechanisms of colorectal liver metastasis development
Colorectal cancer (CRC) is a leading cause of cancer-related death worldwide, largely due to the development of colorectal liver metastases (CRLM)....
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Beyond the barrier: the immune-inspired pathways of tumor extravasation
Extravasation is a fundamental step in the metastatic journey, where cancer cells exit the bloodstream and breach the endothelial cell barrier to...
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A semi-automated, high throughput approach for O-glycosylation profiling of in vitro established cancer cell lines by MALDI-FT-ICR MS
The study of protein O -glycosylation is important in biological research as O -glycans have been reported to regulate a multitude of molecular and...
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Enhancing mesenchymal stem cell survival and homing capability to improve cell engraftment efficacy for liver diseases
Although mesenchymal stem cell (MSC) transplantation provides an alternative strategy for end-stage liver disease (ESLD), further widespread...
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Radiation therapy improves CAR T cell activity in acute lymphoblastic leukemia
Autologous T cells engineered to express a chimeric antigen receptor (CAR) specific for CD19 are approved for the treatment of various CD19 + ...
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The challenge of determining the impact of FUT3 tumor-associated polymorphism rs2306969 (-6951 C> T) in invasive breast cancer cells
FUT3 gene is responsible for encode an homonymous α1,3/4-fucosyltransferase involved in the synthesis of sialyl-Lewis antigens. FUT3-fucosylated...
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Targeting CD24 as a novel immunotherapy for solid cancers
Cluster of differentiation 24 (CD24), a mucin-like highly glycosylated molecule has been extensively studied as a cancer stem cell marker in a...
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Aberrant Protein Glycosylation in Brain Cancers, with Emphasis on Glioblastoma
Aberrant glycosylation has been associated with several processes of tumorigenesis from cell signaling, migration and invasion, to immune regulation...
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Pectolinarigenin regulates the tumor-associated proteins in AGS-xenograft BALB/c nude mice
BackgroundPectolinarigenin (PEC) is a flavone extracted from Cirsium , and because it has anti-inflammatory properties, anti-cancer research is also...
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Mucin-Type O-GalNAc Glycosylation in Health and Disease
Mucin-type GalNAc O-glycosylation is one of the most abundant and unique post-translational modifications. The combination of proteome-wide map**...
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Helicobacter pylori: an up-to-date overview on the virulence and pathogenesis mechanisms
Helicobacter pylori is an organism associated with ulcer disease and gastric cancer. The latter is one of the most prevalent malignancies and...
