Search
Search Results
-
Functional EGF domain of the human neuregulin 1α produced in Escherichia coli with accurate disulfide bonds
BackgroundNeuregulins comprise a large family of growth factors containing an epidermal growth factor (EGF) domain. NRG1 acts in signaling pathways...
-
Dedifferentiation of human epidermal melanocytes in vitro by long-term trypsinization
Human epidermal melanocytes can be induced to form melanocyte spheroids and revert to immature characteristics by long-term trypsinization (LTT). To...
-
Recombinant Protein Production in Plants: A Brief Overview of Strengths and Challenges
The first recombinant proteins were produced in microbes and animal cells cultivated in bioreactors. These systems have become the standard for...
-
Optimizing Human Epidermal Growth Factor for its Endurance and Specificity Via Directed Evolution: Functional Importance of Leucine at Position 8
Epidermal growth factor regulates cell proliferation and migration by binding and activating the extracellular region of its receptor. Many...
-
GDF-11 downregulates placental human chorionic gonadotropin expression by activating SMAD2/3 signaling
BackgroundThe production of human chorionic gonadotropin (hCG) by the placental trophoblast cells is essential for maintaining a normal pregnancy....
-
Synergistic Effect of Laminin and Epidermal Growth Factor on Biological and Morphological Properties of Co-Cultured Myoblasts and Fibroblasts
Background:One of the long-standing problems of myoblasts in vitro expansion is slow cell migration and this causes fibroblast population to exceed...
-
Transdermal peptide conjugated to human connective tissue growth factor with enhanced cell proliferation and hyaluronic acid synthesis activities produced by a silkworm silk gland bioreactor
AbstractHuman connective tissue growth factor (CTGF) is a secreted cysteine-rich peptide that stimulates cell proliferation, migration, and...
-
Recombinant Analogue of the Human Protein SLURP-1 Inhibits the Growth of Multicellular Spheroids Reconstructed from Carcinoma Cells
AbstractIn the present study we showed that the recombinant analogue of the SLURP-1 protein effectively inhibits the growth of a 3D model of...
-
Construction of Human Immune and Naive scFv Phage Display Libraries
Antibody phage display is a widely used in vitro selection technology for the generation of human recombinant antibodies and has yielded thousands of...
-
Cerebral organoids display dynamic clonal growth and tunable tissue replenishment
During brain development, neural progenitors expand through symmetric divisions before giving rise to differentiating cell types via asymmetric...
-
PRMT5-mediated methylation of STAT3 is required for lung cancer stem cell maintenance and tumour growth
STAT3 is constitutively activated in many cancer types, including lung cancer, and can induce cancer cell proliferation and cancer stem cell (CSC)...
-
Topical administration of the secretome derived from human amniotic epithelial cells ameliorates psoriasis-like skin lesions in mice
BackgroundPsoriasis is a chronic inflammatory skin disease. Tissue stem cells have exhibited a therapeutic effect on psoriatic mice. However, the...
-
Novel engineered HER2 specific recombinant protein nanocages for targeted drug delivery
Protein nanocages resemble natural biomimetic carriers and can be engineered to act as targeted delivery systems, making them an attractive option...
-
EFR3A: a new raft domain organizing protein?
BackgroundMembrane rafts play a crucial role in the regulation of many important biological processes. Our previous data suggest that specific...
-
Snail mediates GDF-8-stimulated human extravillous trophoblast cell invasion by upregulating MMP2 expression
BackgroundExtravillous trophoblast (EVT) cell invasion is a tightly regulated process that requires for a normal pregnancy. The...
-
Endothelin-1 mediated glycosaminoglycan synthesizing gene expression involves NOX-dependent transactivation of the transforming growth factor-β receptor
G protein-coupled receptor (GPCR) agonist endothelin-1 (ET-1) through transactivation of the transforming growth factor (TGF) β receptor (TGFBR1)...
-
Recombinant thrombomodulin domain 1 rescues pathological angiogenesis by inhibition of HIF-1α-VEGF pathway
Pathological angiogenesis (PA) contributes to various ocular diseases, including age-related macular degeneration, diabetic retinopathy, and...
-
Directed Differentiation of Murine and Human Small Intestinal Organoids Toward All Mature Lineages
Intestinal organoids are three-dimensional structures derived from tissue-resident adult stem cells. These organoids recapitulate key aspects of...
-
Tree peony transcription factor PrWRI1 enhances seed oil accumulation
BackgroundWRINKLED1 ( WRI1 ) encodes a transcription factor, belonging to the APETALA2 (AP2) family, and plays a key role in regulating plant oil...
-
A fully human anti-c-Kit monoclonal antibody 2G4 inhibits proliferation and degranulation of human mast cells
Given that mast cells are pivotal contributors to allergic diseases, various allergy treatments have been developed to inhibit them. Omalizumab, an...
