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In vivo identification of astrocyte and neuron subproteomes by proximity-dependent biotinylation
The central nervous system (CNS) comprises diverse and morphologically complex cells. To understand the molecular basis of their physiology, it is...
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Transfer of cGAMP from neuron to microglia activates microglial type I interferon responses after subarachnoid hemorrhage
Primary subarachnoid hemorrhage (SAH) is a type of acute stroke, accounting for approximately 10% of cases, with high disability and mortality rate....
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Automated neuron tracking inside moving and deforming C. elegans using deep learning and targeted augmentation
Reading out neuronal activity from three-dimensional (3D) functional imaging requires segmenting and tracking individual neurons. This is challenging...
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Impact of NMDA receptor activation on DNA damage in PC12 neuron-like cell cultures in the presence of β-amyloid peptides
ObjectiveThis study aimed to investigate the effect of low nanomolar concentrations of Aβ1–40 and Aβ25–35 on DNA double-strand breaks following NMDA...
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Long-term caffeine treatment of Alzheimer mouse models ameliorates behavioural deficits and neuron loss and promotes cellular and molecular markers of neurogenesis
Epidemiological studies indicate that the consumption of caffeine, the most commonly ingested psychoactive substance found in coffee, tea or soft...
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Joint reconstruction of neuron and ultrastructure via connectivity consensus in electron microscope volumes
BackgroundNanoscale connectomics, which aims to map the fine connections between neurons with synaptic-level detail, has attracted increasing...
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Reinforcing neuron extraction and spike inference in calcium imaging using deep self-supervised denoising
Calcium imaging has transformed neuroscience research by providing a methodology for monitoring the activity of neural circuits with single-cell...
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Role of the Mast Cell–Neuron Tandem in Cardiac Function Regulation in Cardiovascular Pathologies
AbstractThe review addresses new data on the involvement of mast cells (MCs) in the regulation of cardiac function during the development of some...
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The Effect of Pronase on Mollusk, Leech, and Frog Nerve Ganglia Causes the Formation of Neuron–Neuronal Gap Junctions
Abstract—Using electron microscopy, the effect of pronase on nerve ganglia of a mollusk, leech, and frog was studied for the first time. It was...
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Single-cell alternative polyadenylation analysis delineates GABAergic neuron types
BackgroundAlternative polyadenylation (APA) is emerging as an important mechanism in the post-transcriptional regulation of gene expression across...
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Brain size and neuron numbers drive differences in yawn duration across mammals and birds
Recent studies indicate that yawning evolved as a brain cooling mechanism. Given that larger brains have greater thermolytic needs and brain...
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Measuring neuron-regulated immune cell physiology via the alpha-2 adrenergic receptor in an ex vivo murine spleen model
The communication between the nervous and immune systems plays a crucial role in regulating immune cell function and inflammatory responses....
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Impaired synaptic plasticity and decreased glutamatergic neuron excitability induced by SIRT1/BDNF downregulation in the hippocampal CA1 region are involved in postoperative cognitive dysfunction
BackgroundPostoperative cognitive dysfunction (POCD) is a common complication after anesthesia/surgery, especially among elderly patients, and poses...
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Novel chemical inhibitor against SOD1 misfolding and aggregation protects neuron-loss and ameliorates disease symptoms in ALS mouse model
Amyotrophic Lateral Sclerosis (ALS) is a fatal neurodegenerative disease characterized by selective death of motor neurons. Mutations in Cu,...
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Mouse Neural Stem Cell Differentiation and Human Adipose Mesenchymal Stem Cell Transdifferentiation Into Neuron- and Oligodendrocyte-like Cells With Myelination Potential
Stem cell therapy is an interesting approach for neural repair, once it can improve and increase processes, like angiogenesis, neurogenesis, and...
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Atomoxetine Decreases Mitochondrial Biogenesis, Fission and Fusion In Human Neuron-like Cells But Does Not Alter Antioxidant Defences
Atomoxetine (ATX) is a presynaptic norepinephrine transporter (NET) inhibitor widely prescribed for attention-deficit/hyperactivity disorder (ADHD)...
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Neuron and astrocyte aggregation and sorting in three-dimensional neuronal constructs
Aggregation and self-sorting of cells in three dimensional cultures have been described for non-neuronal cells. Despite increased interest in...
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Neuron-targeted overexpression of caveolin-1 alleviates diabetes-associated cognitive dysfunction via regulating mitochondrial fission-mitophagy axis
BackgroundType 2 diabetes mellitus (T2DM) induced diabetes-associated cognitive dysfunction (DACD) that seriously affects the self-management of T2DM...
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MiR-370-3p aggravates blood–brain barrier injury and neuron apoptosis by targeting SMURF1 to activate the TLR4/MyD88/NF-κB signaling in sepsis-associated encephalopathy
BackgroundSepsis-associated encephalopathy (SAE) is characterized by blood–brain barrier (BBB) disruption, neuron apoptosis and inflammation. Studies...
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Global transcriptome profile of the developmental principles of in vitro iPSC-to-motor neuron differentiation
BackgroundHuman induced pluripotent stem cells (iPSC) have opened new avenues for regenerative medicine. Consequently, iPSC-derived motor neurons...
