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Advances in the regulation of plant salt-stress tolerance by miRNA
Salt stress significantly affects the growth, development, yield, and quality of plants. MicroRNAs (miRNAs) are involved in various stress responses...
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Parallel degradome-seq and DMS-MaPseq substantially revise the miRNA biogenesis atlas in Arabidopsis
MicroRNAs (miRNAs) are produced from highly structured primary transcripts (pri-miRNAs) and regulate numerous biological processes in eukaryotes. Due...
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Optimized Protocol for Plasma-Derived Extracellular Vesicles Loading with Synthetic miRNA Mimic Using Electroporation
Extracellular vesicles (EVs) are a population of particles naturally released by cells to transport biological messages, including nucleic acids....
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Temporal expression analysis of microRNAs and their target GRAS genes induced by osmotic stress in two contrasting wheat genotypes
BackgroundMicroRNAs (miRNAs) are important nonprotein-coding genes in plants which participate in almost all biological processes during abiotic and...
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Integrated analysis of miRNA-mRNA regulatory network and functional verification of miR-338-3p in coronary heart disease
Coronary heart disease is a cardiovascular disease with high morbidity and mortality. Although great progress has been made in treatment, the...
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Gene Reporter Assays to Study miRNA Function
This chapter describes one of the most reliable quantitative assays to test the silencing of a possible target gene by a specific miRNA using a...
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PmliHFM: Predicting Plant miRNA-lncRNA Interactions with Hybrid Feature Mining Network
Due to the crucial role of interactions between microRNAs (miRNAs) and long non-coding RNAs (lncRNAs) in biological processes, the study of their...
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Widespread 8-oxoguanine modifications of miRNA seeds differentially regulate redox-dependent cancer development
Oxidative stress contributes to tumourigenesis by altering gene expression. One accompanying modification, 8-oxoguanine (o 8 G) can change RNA–RNA...
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Systematic analyzing a five- miRNA panel and its diagnostic value of plasma expression in colorectal cancer
BackgroundAberrant expression of miRNAs have been implicated in cancers, but the role of miRNAs in colorectal cancer (CRC) remains need to be...
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Plastid retrograde regulation of miRNA expression in response to light stress
BackgroundMicroRNAs (miRNAs) are a class of endogenous noncoding RNAs that play a pivotal role in the regulation of plant development and responses...
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The Role of MiRNA in Cancer: Pathogenesis, Diagnosis, and Treatment
Cancer is also determined by the alterations of oncogenes and tumor suppressor genes. These gene expressions can be regulated by microRNAs (miRNA)....
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Impact of fetal exposure to mycotoxins on longissimus muscle fiber hypertrophy and miRNA profile
BackgroundLongissimus muscle samples were collected from lambs exposed in utero to mycotoxins [E-, endophyte-free tall fescue seed without ergot...
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Expression of juvenility related microRNAs and target genes during micropropagation of silver birch (Betula pendula Roth.)
Silver birch ( Betula pendula Roth.) is an ecologically and economically important deciduous tree species in Northern Europe. In vitro culture...
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Screening of differentially expressed microRNAs and target genes in two potato varieties under nitrogen stress
BackgroundA reasonable supply of nitrogen (N) fertilizer is essential for obtaining high-quality, high-level, and stable potato yields, and an...
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Identification of a miRNA multi-targeting therapeutic strategy in glioblastoma
Glioblastoma (GBM) is a deadly and the most common primary brain tumor in adults. Due to their regulation of a high number of mRNA transcripts,...
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Identification of lncRNA, miRNA and mRNA expression profiles and ceRNA Networks in small cell lung cancer
BackgroundSmall cell lung cancer (SCLC) is a highly lethal malignant tumor. It accounts for approximately 15% of newly diagnosed lung cancers. Long...
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miRNA Regulatory Networks Underlying the Root–Leaf Synergism in Salt Tolerant Pokkali Rice
Pokkali is one of the rice varieties that have adapted to grow under highly saline conditions. Several studies have shown that plant’s response to...
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Exosomal MicroRNAs: Comprehensive Methods from Exosome Isolation to miRNA Extraction and Purity Analysis
Exosomes are extracellular vesicles secreted by cells with a key role in a wide range of biological processes including cancer. These vesicles are...
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Integrated analysis of the expression profiles of the lncRNA-miRNA-mRNA ceRNA network in granulosa and cumulus cells from yak ovaries
BackgroundGrowing oocytes acquire the ability to mature through two-way communication between gametes and surrounding somatic cumulus cells (CCs)....
