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CDC167 exhibits potential as a biomarker for airway inflammation in asthma
Current asthma treatments have been discovered to decrease the risk of disease progression. Herein, we aimed to characterize novel potential...
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Inhibition of phosphoinositide 3-kinase activity attenuates neutrophilic airway inflammation and inhibits pyrin domain-containing 3 inflammasome activation in an ovalbumin-lipopolysaccharide-induced asthma murine model
BackgroundExisting investigations suggest that the blockade of phosphoinositide 3-kinase (PI3K) activity contributes to inflammatory solution in...
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Mitigation of acute lung injury by human bronchial epithelial cell-derived extracellular vesicles via ANXA1-mediated FPR signaling
Acute lung injury (ALI) is characterized by respiratory failure resulting from the disruption of the epithelial and endothelial barriers as well as...
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Pseudomonas aeruginosa polysaccharide Psl supports airway microbial community development
Pseudomonas aeruginosa dominates the complex polymicrobial cystic fibrosis (CF) airway and is a leading cause of death in persons with CF. Oral...
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Plasma lipid biomarkers in relation to BMI, lung function, and airway inflammation in pediatric asthma
IntroductionThere is limited understanding of how plasma fatty acid levels affect pulmonary function in pediatric years. It has been speculated that...
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LKB1 deficiency upregulates RELM-α to drive airway goblet cell metaplasia
Targeting airway goblet cell metaplasia is a novel strategy that can potentially reduce the chronic obstructive pulmonary disease (COPD) symptoms....
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Therapeutic Effects of Human Pluripotent Stem Cell-Derived Mesenchymal Stem Cells on a Murine Model of Acute Type-2-Dominated Airway Inflammation
Allergic rhinitis and allergic asthma are the most common type-2 inflammatory diseases, which are hardly curable and cause heavy burden to general...
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The Role of the Notch Signaling Pathway in Pathogenesis of Lung Diseases with Noninfectious Etiology
AbstractThis review presents current literature data on significance of the Notch signaling pathway in mechanisms of the development of respiratory...
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Single-cell RNA sequencing reveals the developmental program underlying proximal–distal patterning of the human lung at the embryonic stage
The lung is the primary respiratory organ in human, in which the proximal airway and the distal alveoli are responsible for air conduction and gas...
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Lipopeptide Biosurfactant Produced by Acinetobacter junii B6 Attenuates Lung Inflammatory, Oxidative, and Histopathological Alterations due to Asthma in Rats
The two main characteristics of asthma pathogenesis are severe inflammation and excessive oxidative stress production. Biosurfactant (BS), as...
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Guggulsterone protects against cigarette smoke-induced COPD linked lung inflammation
Recently, we have shown that guggulsterone is the principal constituent responsible for protective effects of Commiphora wightii against...
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Lung Organoids: A New Pathway into Lung Regeneration and Repair
Introduction: The lung is an important and complicated organ that has profound impacts on the entire body when impacted by disease or illness. Due to...
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Role of necroptosis in airflow limitation in chronic obstructive pulmonary disease: focus on small-airway disease and emphysema
Airflow limitation with intractable progressive mechanisms is the main disease feature of chronic obstructive pulmonary disease (COPD). The...
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3D tissue-engineered lung models to study immune responses following viral infections of the small airways
Small airway infections caused by respiratory viruses are some of the most prevalent causes of illness and death. With the recent worldwide pandemic...
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Lung Organoids: Systematic Review of Recent Advancements and its Future Perspectives
Organoids are essentially an in vitro (lab-grown) three-dimensional tissue culture system model that meticulously replicates the structure and...
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Using 3-Dimensional Cultures to Propagate Genetically Modified Lung Organoids
Transformed lung organoids have extensive applications in lung cancer modeling and drug screening. Traditional two-dimensional (2D) cultures fail to...
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An Introduction to Engineering and Modeling the Lung
Over the last decade, the field of lung biology has evolved considerably due to many advancements, including the advent of single-cell RNA (scRNA)...
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Restoration of SIRT3 gene expression by airway delivery resolves age-associated persistent lung fibrosis in mice
Aging is a risk factor for progressive fibrotic disorders involving diverse organ systems, including the lung. Idiopathic pulmonary fibrosis, an...
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Expandable Lung Epithelium Differentiated from Human Embryonic Stem Cells
BackgroundThe progenitors to lung airway epithelium that are capable of long-term propagation may represent an attractive source of cells for...
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MSCs alleviate LPS-induced acute lung injury by inhibiting the proinflammatory function of macrophages in mouse lung organoid–macrophage model
Acute lung injury (ALI) is an inflammatory disease associated with alveolar injury, subsequent macrophage activation, inflammatory cell infiltration,...
