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Characterization of the Nanog gene involved in the gonadal development in pearlscale angelfish (Centropyge vrolikii)
The homeodomain transcription factor Nanog plays a crucial role in the embryonic and gonadal development and the maintenance of embryonic stem cells...
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The transcriptional regulator HDP1 controls expansion of the inner membrane complex during early sexual differentiation of malaria parasites
Transmission of Plasmodium falciparum and other malaria parasites requires their differentiation from asexual blood stages into gametocytes, the...
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The Role of PHF6 in Hematopoiesis and Hematologic Malignancies
Epigenetic regulation of gene expression represents an important mechanism in the maintenance of stem cell function. Alterations in epigenetic...
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Homeobox Genes and Homeodomain Proteins: New Insights into Cardiac Development, Degeneration and Regeneration
Cardiovascular diseases are the most common cause of human death in the develo** world. Extensive evidence indicates that various toxic...
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Brachiopod and mollusc biomineralisation is a conserved process that was lost in the phoronid–bryozoan stem lineage
BackgroundBrachiopods and molluscs are lophotrochozoans with hard external shells which are often believed to have evolved convergently. While...
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Functional and regulatory diversity of homeobox-leucine zipper transcription factors BnaHB6 under dehydration and salt stress in Brassica napus L.
The plant-specific homeodomain-leucine zipper I subfamily is involved in the regulation of various biological processes, particularly growth,...
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Genome-wide analysis of TALE superfamily in Triticum aestivum reveals TaKNOX11-A is involved in abiotic stress response
BackgroundThree-amino-loop-extension (TALE) superfamily genes are widely present in plants and function directly in plant growth and development and...
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A Micro-evolutionary Change in Target Binding Sites as a Key Determinant of Ultrabithorax Function in Drosophila
Hox genes encode Homeodomain-containing transcription factors, which specify segmental identities along the anterior–posterior axis. Functional...
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A redundant transcription factor network steers spatiotemporal Arabidopsis triterpene synthesis
Plant specialized metabolites modulate developmental and ecological functions and comprise many therapeutic and other high-value compounds. However,...
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The Historical Relationship Between Meis1 and Leukemia
Acute leukemia (AL) is a poor progressive resistant hematological disease, which has different subtypes and immunophenotypic properties according to...
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SlZHD17 is involved in the control of chlorophyll and carotenoid metabolism in tomato fruit
Chlorophylls and carotenoids are essential and beneficial substances for both plant and human health. Identifying the regulatory network of these...
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Whole plant response of Pongamia pinnata to drought stress tolerance revealed by morpho-physiological, biochemical and transcriptome analysis
BackgroundPongamia is considered an important biofuel species worldwide. Drought stress in the early growth stages of Pongamia influences negatively...
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Genome-wide investigation of the ZF-HD gene family in two varieties of alfalfa (Medicago sativa L.) and its expression pattern under alkaline stress
BackgroundZinc finger homeodomain (ZHD) protein is a plant-specific transcription factor and a potential regulator of phosphoenolpyruvate carboxylase...
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Tec1 and Ste12 transcription factors play a role in adaptation to low pH stress and biofilm formation in the human opportunistic fungal pathogen Candida glabrata
Eukaryotic cells respond to environmental cues through mitogen activated protein kinase (MAPK) signaling pathways. Each MAPK cascade is specific to...
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Ectopic expression of WOX5 promotes cytokinin signaling and de novo shoot regeneration
Key messageWOX5 has a potential in activating cytokinin signaling and shoot regeneration, in addition to its role in pluripotency acquisition. Thus,...
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Liquid–liquid phase separation of H3K27me3 reader BP1 regulates transcriptional repression
BackgroundBromo-adjacent homology-plant homeodomain domain containing protein 1 (BP1) is a reader of histone post-translational modifications in...
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Trimeric complexes of Antp-TBP with TFIIEβ or Exd modulate transcriptional activity
BackgroundHox proteins finely coordinate antero-posterior axis during embryonic development and through their action specific target genes are...
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A Light-Inducible Bidirectional Promoter Initiates Expression of Both Genes SHH2 and CFM3 in Brassica napus L.
A bidirectional promoter is an intergenic region between a pair of adjacent and oppositely transcribed genes (‘head-to-head’ genes) that concurrently...
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PHF5A promotes esophageal squamous cell carcinoma progression via stabilizing VEGFA
BackgroundEsophageal squamous cell carcinoma (ESCC) is the main subtype of esophageal cancer. Current therapeutic effect is far from satisfaction....
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Identification of PavHB16 gene in Prunus avium and validation of its function in Arabidopsis thaliana
Sweet cherry ( Prunus avium L.) is one of the most economically important fruits in the world. However, severe fruit abscission has brought...
