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Chemical screening links disulfiram with cardiac protection after ischemic injury
Ischemia–reperfusion injury occurs after reperfusion treatment for patients suffering myocardial infarction, however the underlying mechanisms are...
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Screening of cucumber genotypes against downy mildew disease and its relationship with biochemical parameters
Downy mildew caused by Pseudoperonospora cubensis (Berk. and Curt.) Rostow, is an important disease of cucumber in the Gangetic plains of eastern...
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Optimization of inoculum production of Stemphylium botryosum for large-scale resistance screening of lentils
BackgroundStemphylium blight incited by Stemphylium botryosum poses a significant threat to lentil crops worldwide, inducing severe defoliation and...
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Repurposing FDA approved drugs against monkeypox virus DNA dependent RNA polymerase: virtual screening, normal mode analysis and molecular dynamics simulation studies
Zoonotic monkeypox disease, caused by the double-stranded DNA monkeypox virus, has become a global concern. Due to the absence of a specific small...
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M-US-EMRs: A Multi-modal Data Fusion Method of Ultrasonic Images and Electronic Medical Records Used for Screening of Coronary Heart Disease
Coronary heart disease (CHD) is the leading cause of death and disease burden in China and world-wide. The accurate screening for CHD can be of great...
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2D Photogrammetry Image of Adolescent Idiopathic Scoliosis Screening Using Deep Learning
Adolescent idiopathic scoliosis (AIS) is a high incidence disease in adolescents, with a long treatment time and difficult to cure. As a consensus,...
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Semi-quantitative group testing for efficient and accurate qPCR screening of pathogens with a wide range of loads
BackgroundPathogenic infections pose a significant threat to global health, affecting millions of people every year and presenting substantial...
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Designing and expression of novel recombinant fusion protein for efficient antigen screening of SARS-CoV-2
Corona virus disease 2019 (COVID-19) pandemic caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), claimed millions globally....
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Rational Design of Drugs Targeting G-Protein-Coupled Receptors: Ligand Search and Screening
AbstractG protein-coupled receptors (GPCRs) are transmembrane proteins that participate in many physiological processes and represent major...
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Screening for urdbean leaf crinkle disease at field condition in blackgram [Vigna mungo (L.) Hepper]
Urdbean leaf crinkle disease (ULCD) is one of the most destructive diseases of blackgram. The causal agent is reported to be transmitted by whitefly,...
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Medicine and Disease
This chapter deals with a selection of medical applications of bioinformatics, starting with genetically based diseases and the use of...
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Genetic screening in a Brazilian cohort with inborn errors of immunity
BackgroundInherited genetic defects in immune system-related genes can result in Inborn Errors of Immunity (IEI), also known as Primary...
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Screening of Endophytes for Antibacterial Properties
Endophytes are microbes that reside inside the tissues of healthy plants with the varied relationship but not producing any disease symptoms...
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Engineered human hepatocyte organoids enable CRISPR-based target discovery and drug screening for steatosis
The lack of registered drugs for nonalcoholic fatty liver disease (NAFLD) is partly due to the paucity of human-relevant models for target discovery...
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Prenatal Screening and Counseling for Rare Genetic Disorders
Genetic counseling is an important component of healthcare that provides individuals and families affected by rare genetic illnesses with important...
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Tissue-Specific CRISPR-Cas9 Screening in Drosophila
Over the last century research in Drosophila has resulted in many fundamental contributions to our understanding of the biology of multicellular...
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Identification of the potential TLR7 antagonists by virtual screening and experimental validation
Toll-like receptor 7 (TLR7) is highly expressed in dendritic cells (DCs) and B cells, and its aberrant activation can promote disease progression in...
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Screening Carbon Nano Materials for Preventing Amyloid Protein Aggregation by Adopting a Facile Method
The soluble-to-toxic transformation of intrinsically disordered amyloidogenic proteins such as amyloid beta (Aβ), α-synuclein, mutant Huntingtin...
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Celiac Disease: Myth or Reality
The amount and quality of wheat gluten which includes heterogeneous mixtures of storage proteins, namely glutenin and gliadin, are accepted as the...
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Mango germplasm screening for the identification of sources of tolerance to anthracnose
Colletotrichum species are one of the most common causes of postharvest fruit rot in mango in Australia, particularly in the tropical region of north...
