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Curcumin Displays Enhanced Solubility and Antibacterial Activities When Complexed with the Cell Penetrating Peptide pVEC
Curcumin is among phytochemicals with increasing popularity; unfortunately, its therapeutic potential is restricted due to poor water solubility and...
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Superoxide dismutase: a key target for the neuroprotective effects of curcumin
Over the past few years, the prevalence of neurodegenerative diseases (NDD) has increased dramatically. The community health system is burdened by...
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Role of curcumin in ameliorating hypertension and associated conditions: a mechanistic insight
Curcumin, belongs to the curcuminoid family, is a natural phenolic compound, presenting low bioavailability and pleiotropic activity. Since ancient...
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Biochemical and Histological Studies on the Protective Effects of Curcumin against Acetamiprid-Induced Hepato-Renal Toxicity
AbstractThe present study aims to investigate the possible liver and kidney toxicity mechanisms of prolonged acetamiprid (ACMP) induction and the...
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Identification and targeting of metastatic biomarkers for hepatocellular carcinoma therapeutics using small molecules library of curcumin analogues
The understanding of the molecular basis of complex diseases like hepatocellular carcinoma (HCC) needs large datasets of multiple genes and proteins...
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Effect of curcumin nanoparticles and alcoholic extract of Falcaria vulgaris on the growth rate, biofilm, and gene expression in Pseudomonas aeruginosa isolated from burn wound infection
PurposeThis study aimed to investigate the effect of Curcumin nanoparticles and alcoholic extract of Falcaria vulgaris on the growth rate, biofilm,...
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Curcumin and NCLX inhibitors share anti-tumoral mechanisms in microsatellite-instability-driven colorectal cancer
Background and aimsRecent evidences highlight a role of the mitochondria calcium homeostasis in the development of colorectal cancer (CRC). To...
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Curcumin induces apoptosis through caspase dependent pathway in human colon carcinoma cells
BackgroundWe investigated the apoptotic effects of curcumin in the colon carcinoma cell line SW480.
Methods and resultsCells were treated with...
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Curcumin-loaded human endometrial stem cells derived exosomes as an effective carrier to suppress alpha-synuclein aggregates in 6OHDA-induced Parkinson’s disease mouse model
Parkinson disease (PD) is considered as one of the most worldwide neurodegenerative disorders. The major reasons associated to neurodegeneration...
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Curcumin sensitizes carboplatin treatment in triple negative breast cancer through reactive oxygen species induced DNA repair pathway
BackgroundAs patients with triple-negative breast cancer (TNBC) have a very weak response to hormone inhibition or anti-HER2 therapy, traditional...
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Curcumin suppresses cell proliferation and reduces cholesterol absorption in Caco-2 cells by activating the TRPA1 channel
BackgroundCurcumin (Cur) is a bioactive dietary polyphenol of turmeric with various biological activities against several cancers. Colorectal cancer...
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Pluronic F127-liposome-encapsulated curcumin activates Nrf2/Keap1 signaling pathway to promote cell migration of HaCaT cells
Curcumin (CUR) is an extract of Curcuma longa Linn., which has various pharmacological activities. The instability, low water solubility and...
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Multifunctional curcumin mediated zinc oxide nanoparticle enhancing biofilm inhibition and targeting apoptotic specific pathway in oral squamous carcinoma cells
BackgroundOral health remains a significant global concern with the prevalence of oral pathogens and the increasing incidence of oral cancer posing...
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Testing the Effect of Curcumin on Proliferative Capacity of Colorectal Cancer Cells
This chapter presents a protocol for studying the effects of curcumin in a colorectal cell line and a mouse model of colitis-associated colon...
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Curcumin-based-fluorescent probes targeting ALDH1A3 as a promising tool for glioblastoma precision surgery and early diagnosis
Glioblastoma (GBM) is the most aggressive primary brain tumour for which both effective treatments and efficient tools for an early-stage diagnosis...
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The Therapeutic Effects of Curcumin-coated Gold Nanoparticle Against Leishmania Major Causative Agent of Zoonotic Cutaneous Leishmaniasis (ZCL): An In Vitro and In Vivo Study
We synthesized and characterized curcumin-coated gold nanoparticles (Cur@AuNPs) and investigated their stability, cytotoxicity, leishmanicidal...
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Cardiac fibrosis and curcumin: a novel perspective on this natural medicine
BackgroundAccording to WHO statistics, cardiovascular disease are the leading causes of death in the world. One of the main factors which is causing...
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Curcumin inhibition of bleomycin-induced changes in lung collagen synthesis, deposition and assembly
BackgroundIdiopathic pulmonary fibrosis is characterized by progressive lung tissue remodeling and disproportionate deposition of collagenous...
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Arsenic induced chromosomal aberrations, biochemical and morphological changes in Vigna radiata L. (Mung bean) seedlings and its amelioration by Curcumin
The responses to arsenic (As) and curcumin (Cur) were examined in Vigna radiata L. (Mung bean) seedlings in order to evaluate the role of Cur in...
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Protective effect of curcumin on the kidney of diclofenac sodium-challenged mice: apoptotic, redox potential and histopathological outcomes
BackgroundThe renal burden imposed by diclofenac sodium (DS) remedy is a significant concern and limits the extension in its clinical application....
