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Computational approaches and challenges in the analysis of circRNA data
Circular RNAs (circRNA) are a class of non-coding RNA, forming a single-stranded covalently closed loop structure generated via back-splicing....
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Circ_0000277 promotes the malignant progression of oesophageal squamous cell carcinoma through miR-1294-dependent regulation of DVL3
BackgroundRecent studies have pinpointed that circular RNA (circRNA) regulates diverse cellular processes in oesophageal squamous cell carcinoma...
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Integrated small RNA, mRNA and protein omics reveal a miRNA network orchestrating metabolic maturation of the develo** human heart
BackgroundAs the fetal heart develops, cardiomyocyte proliferation potential decreases while fatty acid oxidative capacity increases in a highly...
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circRNA-SFMBT2 orchestrates ERα activation to drive tamoxifen resistance in breast cancer cells
Dysregulated ERα signaling is responsible for endocrine resistance and eventual relapse in patients with estrogen receptor-positive (ER + ) breast...
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circRNAs expressed in human peripheral blood are associated with human aging phenotypes, cellular senescence and mouse lifespan
Circular RNAs (circRNAs) are an emerging class of non-coding RNA molecules that are thought to regulate gene expression and human disease. Despite...
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CircAKT3 alleviates postoperative cognitive dysfunction by stabilizing the feedback cycle of miR-106a-5p/HDAC4/MEF2C axis in hippocampi of aged mice
Circular RNAs (circRNAs) have garnered significant attention in the field of neurodegenerative diseases including Alzheimer’s diseases due to their...
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Emerging roles of non-coding RNAs in psoriasis pathogenesis
Psoriasis is a complex genetic skin disorder typically manifested by red, scaly, and itchy plaques most commonly over the scalp, trunk, elbows, and...
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Regulation of tumor metastasis and CD8+ T cells infiltration by circRNF216/miR-576-5p/ZC3H12C axis in colorectal cancer
BackgroundThe tumor immune microenvironment (TIME) is an important regulator of tumor progression, growth and metastasis. In addition, tumor...
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A novel microbe-drug association prediction model based on graph attention networks and bilayer random forest
BackgroundIn recent years, the extensive use of drugs and antibiotics has led to increasing microbial resistance. Therefore, it becomes crucial to...
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Predicting metabolite-disease associations based on KATZ model
BackgroundIncreasing numbers of evidences have illuminated that metabolites can respond to pathological changes. However, identifying the...
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CircRNAs: novel therapeutic targets in multiple myeloma
BackgroundCircular RNA (circRNA) is a type of non-coding RNA that has recently attracted the attention of researchers. Multiple myeloma (MM) is a...
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Large-scale benchmarking of circRNA detection tools reveals large differences in sensitivity but not in precision
The detection of circular RNA molecules (circRNAs) is typically based on short-read RNA sequencing data processed using computational tools. Numerous...
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CircRNAs Biogenesis, Functions, and Its Research Progress in Aquaculture
AbstractCircRNAs is a novel type of endogenous RNA molecule that is produced from pre-mRNA without 5′cap and a tail of 3′polyA. It characterized by...
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Zinc as a Mediator Through the ROCK1 Pathway of Cognitive Impairment in Aluminum-Exposed Workers: A Clinical and Animal Study
Aluminum (Al) exposure was implicated in neurodegenerative diseases and cognitive impairment, yet the involvement of zinc (Zn) and its mechanism in...
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Regulatory miRNAs, circRNAs and lncRNAs in cell cycle progression of breast cancer
Breast cancer is a complex and heterogeneous disease that poses a significant public health concern worldwide, and it remains a major challenge...
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The landscape of the long non-coding RNAs and circular RNAs of the abdominal fat tissues in the chicken lines divergently selected for fatness
BackgroundExcessive deposition of abdominal fat poses serious problems in broilers owing to rapid growth. Recently, the evolution of the existing...
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circACTR2 attenuates gemcitabine chemoresiatance in pancreatic cancer through PTEN mediated PI3K/AKT signaling pathway
BackgroundRecently, accumulating studies have unveiled that circRNAs exert critical function in a variety of tumor biological processes including...
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Multi-omics in Human Disease Biomarker Discovery
Sequencing of the human genome has been a major breakthrough that has paved the way to understand the biological functions of various biomolecules....
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Comparative RNA-sequencing analysis of the prostate in a mouse model of benign prostatic hyperplasia with bladder outlet obstruction
In ageing men, benign prostatic hyperplasia (BPH) is a chronic disease that leads to progressive lower urinary tract symptoms (LUTS) caused by...
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Database Resources for Functional Circular RNAs
Circular RNA (or circRNA) is a type of single-stranded covalently closed circular RNA molecule and play important roles in diverse biological...