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Preparation and Characterization of Quantum Dot-Peptide Conjugates Based on Polyhistidine Tags
Quantum dots (QDs) offer bright and robust photoluminescence among several other advantages in comparison to fluorescent dyes. In order to leverage...
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An engineered influenza virus to deliver antigens for lung cancer vaccination
The development of cancer neoantigen vaccines that prime the anti-tumor immune responses has been hindered in part by challenges in delivery of...
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Reprogramming Carbohydrate Metabolism in Cancer and Its Role in Regulating the Tumor Microenvironment
Altered metabolism has become an emerging feature of cancer cells impacting their proliferation and metastatic potential in myriad ways....
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Application of Phage-Displayed Peptides in Tumor Imaging Diagnosis and Targeting Therapy
Phage display is an effective and powerful technique that provides a route to discovery unique peptides targeting to tumor cells. Specifically...
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Research progress of engineered mesenchymal stem cells and their derived exosomes and their application in autoimmune/inflammatory diseases
Autoimmune/inflammatory diseases affect many people and are an important cause of global incidence and mortality. Mesenchymal stem cells (MSCs) have...
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Application of Antimicrobial Peptides in the Design and Production of Anticancer Agents
Antimicrobial peptides (AMPs) are part of the innate immune system of various species. In addition to extensive studies on their probable application...
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A Review of the in Silico Design and Development Approaches of Ras-Specific Anticancer Therapeutics
Ras Proteins, play a pivotal role in the proliferation pathways, and Ras mutant forms are well-established cancer drivers. Ras mutations are found in...
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Efficacy and safety of novel multifunctional M10 CAR-T cells in HIV-1-infected patients: a phase I, multicenter, single-arm, open-label study
Chimeric antigen receptor T (CAR-T) cells have been proposed for HIV-1 treatment but have not yet demonstrated desirable therapeutic efficacy. Here,...
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SARS-COV-2 infection and lung tumor microenvironment
Coronavirus Disease 2019 (COVID-19) is an acute respiratory syndrome, reported at the end of 2019 in China originally and immediately spread...
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Multiple Dimensions of using Mesenchymal Stem Cells for Treating Liver Diseases: From Bench to Beside
Liver diseases impose a huge burden worldwide. Although hepatocyte transplantation has long been considered as a potential strategy for treating...
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Secrets and lies of host–microbial interactions: MHC restriction and trans-regulation of T cell trafficking conceal the role of microbial agents on the edge between health and multifactorial/complex diseases
Here we critically discuss data supporting the view that microbial agents (pathogens, pathobionts or commensals alike) play a relevant role in the...
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The therapeutic potential of multiclonal tumoricidal T cells derived from tumor infiltrating lymphocyte-derived iPS cells
Tumor-infiltrating lymphocytes (TIL), which include tumor-specific T lymphocytes with frequency, are used for adoptive cell transfer therapy (ACT) in...
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Comparison of the different animal modeling and therapy methods of premature ovarian failure in animal model
Incidence of premature ovarian failure (POF) is higher with the increase of the pace of life. The etiology of POF is very complex, which is closely...
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The Therapeutic Effects of an Antimicrobial Peptide Protonectin (IL-12) on A549 Cancer Cell Line
In the study, the impact of protonectin (IL-12) on the bioavailability of human lung carcinoma cell line A549 as well as on HFLF healthy lung...
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Parathyroid Tumor Microenvironment
Parathyroid tumors are the second most common endocrine neoplasia, and it is almost always associated with hypersecretion of the parathormone (PTH),...
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Shedding light on the role of keratinocyte-derived extracellular vesicles on skin-homing cells
Extracellular vesicles (EVs) are secretory lipid membranes with the ability to regulate cellular functions by exchanging biological components...
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Cellular Uptake of Peptides by Confocal Microscopy
Confocal microscopy is a very sensitive and powerful optical imaging technique in vivo and in vitro imaging. Live cell imaging using fluorescence...
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Overcoming acquired resistance to cancer immune checkpoint therapy: potential strategies based on molecular mechanisms
Immune checkpoint inhibitors (ICIs) targeting CTLA-4 and PD-1/PD-L1 to boost tumor-specific T lymphocyte immunity have opened up new avenues for the...
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Mesenchymal stem cells-derived exosomes for drug delivery
Exosomes are extracellular vesicles secreted by various cells, mainly composed of lipid bilayers without organelles. In recent years, an increasing...
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Conventional type 1 dendritic cells (cDC1) in cancer immunity
Cancer immunotherapy, alone or in combination with conventional therapies, has revolutionized the landscape of antineoplastic treatments, with...
