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CD14: Not Just Chaperone, But a Key-Player in Inflammation
The cluster of differentiation 14 (CD14) is a receptor that helps the detection of microbial products, acting as an accessory molecule for several...
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Calcium and Phosphate Ion Uptake, Distribution, and Homeostasis in Cells of Vertebrate Mineralized Tissues
The chapter considers mechanisms by which cells regulate calcium and phosphate ion homeostasis with respect to the induction of extracellular...
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Carotid Body Dysfunction and Mechanisms of Disease
Emerging evidence shows that the carotid body (CB) dysfunction is implicated in various physiological and pathophysiological conditions. It has been...
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Cardiac Inflammasome and Arrhythmia
Cardiac arrhythmias affect the quality of life and are often life threatening. The conventional anti-arrhythmic drugs targeting cardiac ion channels...
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Spatiotemporal control of necroptotic cell death and plasma membrane recruitment using engineered MLKL domains
Necroptosis is a form of programmed necrotic cell death in which a signaling cascade induces oligomerization of mixed lineage kinase domain-like...
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CRISPR/Cas-Mediated Knock-in of Genetically Encoded Fluorescent Biosensors into the AAVS1 Locus of Human-Induced Pluripotent Stem Cells
Genetically encoded fluorescent biosensors (GEFBs) enable researchers to visualize and quantify cellular processes in live cells. Induced pluripotent...
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Types of necroinflammation, the effect of cell death modalities on sterile inflammation
Distinct types of immune responses are activated by infections, which cause the development of type I, II, or III inflammation, regulated by Th1,...
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Inhibition of TRPM7 suppresses cell proliferation of colon adenocarcinoma in vitro and induces hypomagnesemia in vivo without affecting azoxymethane-induced early colon cancer in mice
BackgroundMagnesium (Mg 2+ ) is an essential cation implicated in carcinogenesis, solid tumor progression and metastatic potential. The Transient...
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Calcium signaling: breast cancer’s approach to manipulation of cellular circuitry
Calcium is a versatile element that participates in cell signaling for a wide range of cell processes such as death, cell cycle, division, migration,...
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Chromosome-level Genome Assembly of Acanthopagrus latus Provides Insights into Salinity Stress Adaptation of Sparidae
The yellowfin seabream, Acanthopagrus latus , is widely distributed throughout the Indo-West Pacific. This species, as a euryhaline Sparidae fish,...
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Exosomes-based therapy of stroke, an emerging approach toward recovery
Based on clinical observations, stroke is touted as one of the specific pathological conditions, affecting an individual’s life worldwide. So far, no...
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α1-Adrenergic Stimulation Increases Platelet Adhesion to Endothelial Cells Mediated by TRPC6
Stimulation of a1-adrenergicAdrenergic nervous systemNervous system is increased during systemic inflammationInflammation and other pathological...
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TRPC expression in human periodontal ligament cells and the periodontal tissue of periodontitis mice: a preliminary study
BackgroundTransient receptor potential canonical (TRPC) channels are non-selective cationic channels with permeability to Ca 2+ and Na + . Despite...
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Insights into the Role of Magnesium Ions in Affecting Osteogenic Differentiation of Mesenchymal Stem Cells
Bone marrow mesenchymal stem cells (MSCs) are multipotent stem cells with the ability to differentiate into bone-producing cells, which is essential...
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Cell-Cell Communication in the Vascular Endothelium
The vasculature is a body-wide organ responsible for mass and energy transport throughout the body. In broad terms, all vessels consist of a layer of...
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The role of exosomal microRNAs in central nervous system diseases
MicroRNAs (miRNA), endogenous non-coding RNAs approximately 22 nucleotides long, regulate gene expression by mediating translational inhibition or...
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Comprehensive selection signature analyses in dairy cattle exploiting purebred and crossbred genomic data
The main objective of the current research was to locate, annotate, and highlight specific areas of the bovine genome that are undergoing intense...
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Inhibition of STIM1 alleviates high glucose-induced proliferation and fibrosis by inducing autophagy in mesangial cells
Diabetic nephropathy (DN) is a renal microvascular complication caused by diabetes mellitus. One of the most typical characteristics of DN is...
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Tissue Engineering Strategies to Increase Osteochondral Regeneration of Stem Cells; a Close Look at Different Modalities
The homeostasis of osteochondral tissue is tightly controlled by articular cartilage chondrocytes and underlying subchondral bone osteoblasts via...
