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Acoustic tweezers for high-throughput single-cell analysis
Acoustic tweezers provide an effective means for manipulating single cells and particles in a high-throughput, precise, selective and contact-free...
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Elucidating the role of T-cell exhaustion-related genes in colorectal cancer: a single-cell bioinformatics perspective
Colorectal cancer (CRC) remains a significant global health issue. In this study, the role of T-cell exhaustion-related genes (TEXs) in CRC was...
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Single-Cell Sequencing Technology and Its Application in the Study of Central Nervous System Diseases
The mammalian central nervous system consists of a large number of cells, which contain not only different types of neurons, but also a large number...
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Correlative single-cell hard X-ray computed tomography and X-ray fluorescence imaging
X-ray computed tomography (XCT) and X-ray fluorescence (XRF) imaging are two non-invasive imaging techniques to study cellular structures and...
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Single cell epigenomic and transcriptomic analysis uncovers potential transcription factors regulating mitotic/meiotic switch
In order to reveal the complex mechanism governing the mitotic/meiotic switch in female germ cells at epigenomic and genomic levels, we examined the...
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Single-cell transcriptomics across 2,534 microbial species reveals functional heterogeneity in the rumen microbiome
Deciphering the activity of individual microbes within complex communities and environments remains a challenge. Here we describe the development of...
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Enzyme Identification and Screening: Activity-Based Methods
Methods for the identification and characterization of “ideal” enzymes for industrial use in the field of biotechnology have developed rapidly in...
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Clinical-mediated discovery of pyroptosis in CD8+ T cell and NK cell reveals melanoma heterogeneity by single-cell and bulk sequence
Histologically, melanoma tissues had fewer positive cells percentage of pyroptosis-related genes (PRGs), GZMA, GSDMB, NLRP1, IL18, and CHMP4A in...
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High-capacity sample multiplexing for single cell chromatin accessibility profiling
Single-cell chromatin accessibility has emerged as a powerful means of understanding the epigenetic landscape of diverse tissues and cell types, but...
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Current and future perspectives of single-cell multi-omics technologies in cardiovascular research
Single-cell technology has become an indispensable tool in cardiovascular research since its first introduction in 2009. Here, we highlight the...
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Single-cell multiomics analysis reveals regulatory programs in clear cell renal cell carcinoma
The clear cell renal cell carcinoma (ccRCC) microenvironment consists of many different cell types and structural components that play critical roles...
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Sample-multiplexing approaches for single-cell sequencing
Single-cell sequencing is widely used in biological and medical studies. However, its application with multiple samples is hindered by inefficient...
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Mosaic integration and knowledge transfer of single-cell multimodal data with MIDAS
Integrating single-cell datasets produced by multiple omics technologies is essential for defining cellular heterogeneity. Mosaic integration, in...
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Single-cell dissection of aggression in honeybee colonies
Understanding how genotypic variation results in phenotypic variation is especially difficult for collective behaviour because group phenotypes arise...
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Integrated analysis of single-cell and bulk RNA sequencing data reveals prognostic characteristics of lysosome-dependent cell death-related genes in osteosarcoma
BackgroundTumor cells exhibit a heightened susceptibility to lysosomal-dependent cell death (LCD) compared to normal cells. However, the role of...
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Single-cell molecular profiling using ex vivo functional readouts fuels precision oncology in glioblastoma
BackgroundFunctional profiling of freshly isolated glioblastoma (GBM) cells is being evaluated as a next-generation method for precision oncology....
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Single-cell analysis unveils activation of mast cells in colorectal cancer microenvironment
The role of mast cells (MCs) in colorectal cancer (CRC) remains unclear, and a comprehensive single-cell study on CRC MCs has not been conducted....
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All-optical voltage imaging-guided postsynaptic single-cell transcriptome profiling with Voltage-Seq
Neuronal pathways recruit large postsynaptic populations and maintain connections via distinct postsynaptic response types (PRTs). Until recently,...
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Analysis of Single-Cell Transcriptome Data in Drosophila
The fly Drosophila is a versatile model organism that has led to fascinating biological discoveries. In the past few years, Drosophila researchers...