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Epithelial-mesenchymal transition-related signaling pathways in gastric Cancer cells distinctively respond to long-term experimental ketosis
BackgroundThe interrelationship between cellular metabolism and the epithelial-to-mesenchymal transition (EMT) process has made it an interesting...
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Integrated compact regulators of protein activity enable control of signaling pathways and genome-editing in vivo
Viral proteases and clinically safe inhibitors were employed to build integrated compact regulators of protein activity (iCROP) for...
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Dual blockade of EGFR and PI3K signaling pathways offers a therapeutic strategy for glioblastoma
BackgroundGlioblastoma multiforme (GBM) is a devastating disease that lacks effective drugs for targeted therapy. Previously, we found that the...
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Potential network markers and signaling pathways for B cells of COVID-19 based on single-cell condition-specific networks
To explore the potential network markers and related signaling pathways of human B cells infected by COVID-19, we performed standardized integration...
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Extracellular vesicles-coupled miRNAs from oviduct and uterus modulate signaling pathways related to lipid metabolism and bovine early embryo development
BackgroundExtracellular vesicles (EVs) present in oviductal (OF) and uterine fluid (UF) have been shown to enhance bovine embryo quality during in...
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Integration of light and ABA signaling pathways to combat drought stress in plants
Drought is one of the most critical stresses, which causes an enormous reduction in crop yield. Plants develop various strategies like drought...
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Recent advances on small molecules in osteogenic differentiation of stem cells and the underlying signaling pathways
Bone-related diseases are major contributors to morbidity and mortality in elderly people and the current treatments result in insufficient healing...
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The heterogeneity of signaling pathways and drug responses in intrahepatic cholangiocarcinoma with distinct genetic mutations
Intrahepatic cholangiocarcinoma (ICC) is the second most common malignancy among primary liver cancers, with an increasing overall incidence and poor...
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Muscone inhibits angiotensin II–induced cardiac hypertrophy through the STAT3, MAPK and TGF-β/SMAD signaling pathways
BackgroundMuscone is a chemical monomer derived from musk. Although many studies have confirmed the cardioprotective effects of muscone, the effects...
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Emerging roles of prominin-1 (CD133) in the dynamics of plasma membrane architecture and cell signaling pathways in health and disease
Prominin-1 (CD133) is a cholesterol-binding membrane glycoprotein selectively associated with highly curved and prominent membrane structures. It is...
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Neuronal Calcium Sensor-1: A Zinc/Redox-Dependent Protein of Nervous System Signaling Pathways
AbstractIntracellular calcium signaling is involved in regulating the key functional mechanisms of the nervous system. The control of neuronal...
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Exploring Identifiability in Hybrid Models of Cell Signaling Pathways
Various processes, including growth, proliferation, migration, and death, mediate the activity of a cell. To better understand these processes,...
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UVR8 Signaling, Mechanism, and Integration with Other Pathways
Ultraviolet (UV) is a part of solar spectrum and has 3 subtypes: UV-A, UV-B, and UV-C. Out of them, UV-B has major impact on biological systems. It...
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Sodium humate ameliorates LPS-induced liver injury in mice by inhibiting TLR4/NF-κB and activating NRF2/HO-1 signaling pathways
BackgroundAcute liver damage is a type of liver disease that has a significant global occurrence and a lack of successful treatment and prevention...
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Migraine signaling pathways: purine metabolites that regulate migraine and predispose migraineurs to headache
Migraine is a debilitating disorder that afflicts over 1 billion people worldwide, involving attacks that result in a throbbing and pulsating...
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Periostin: an emerging activator of multiple signaling pathways
Matricellular proteins are responsible for regulating the microenvironment, the behaviors of surrounding cells, and the homeostasis of tissues....
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The role of bone marrow microenvironment (BMM) cells in acute myeloid leukemia (AML) progression: immune checkpoints, metabolic checkpoints, and signaling pathways
Acute myeloid leukemia (AML) comprises a multifarious and heterogeneous array of illnesses characterized by the anomalous proliferation of myeloid...
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Caspase Signaling Pathways as Convenors of Stress Adaptation
Caspase proteins are a group of proteases that manage intermediate and late stages of programmed cell death/apoptosis. Despite the core cell death...
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Natural alternatives targeting psoriasis pathology and key signaling pathways: a focus on phytochemicals
Psoriasis is an autoimmune, chronic skin disorder with complex and yet unclear pathogenesis. It is associated with many conditions, including...
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Inhibition of USP7 upregulates USP22 and activates its downstream cancer-related signaling pathways in human cancer cells
Deubiquitinases (DUBs) play important roles in various human cancers and targeting DUBs is considered as a novel anticancer therapeutic strategy....
