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Early embryonic development of Bombyx
Decades have passed since the early molecular embryogenesis of Drosophila melanogaster was outlined. During this period, the molecular mechanisms...
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Bud31-mediated alternative splicing is required for spermatogonial stem cell self-renewal and differentiation
Alternative splicing (AS) is tightly regulated during cell differentiation and development. AS events are prevalent in the testis, but the splicing...
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The PIWI protein Aubergine recruits eIF3 to activate translation in the germ plasm
Piwi-interacting RNAs (piRNAs) and PIWI proteins are essential in germ cells to repress transposons and regulate mRNAs. In Drosophila , piRNAs bound...
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Low androgen signaling rescues genome integrity with innate immune response by reducing fertility in humans
Development of the gonads under complex androgen regulation is critical for germ cells specification. In this work we addressed the relationship...
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Bi-directional Transcription, Double-Stranded RNA and the Implications on Genome Evolution
Double-stranded RNA (dsRNA) within cells indicates viral infection and triggers a robust innate immune response. Counterintuitively, cells also...
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AUX1, PIN3, and TAA1 collectively maintain fertility in Arabidopsis
Main conclusionWe found that auxin synthesis gene TAA1 and auxin polar transport genes AUX1 and PIN3 collectively maintain fertility and seed size...
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The emerging and diverse roles of F-box proteins in spermatogenesis and male infertility
F-box proteins play essential roles in various cellular processes of spermatogenesis by means of ubiquitylation and subsequent target protein...
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The first embryo, the origin of cancer and animal phylogeny. III. The totipotency as revealed by morphogenesis and the neoplasia controlled by cellular differentiation
We have extensively described that the neoplastic process (NP) has deep evolutionary roots and we have made specific predictions about the connection...
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Molecular characterization of eliminated chromosomes in Hessian fly (Mayetiola destructor (Say))
Like other cecidomyiid Diptera, Hessian fly has stable S chromosomes and dispensable E chromosomes that are retained only in the germ line. Amplified...
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Keep quiet: the HUSH complex in transcriptional silencing and disease
The human silencing hub (HUSH) complex is an epigenetic repressor complex whose role has emerged as an important guardian of genome integrity. It...
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Aedes aegypti exhibits a distinctive mode of late ovarian development
BackgroundInsects live in almost every habitat on earth. To adapt to their diverse environments, insects have developed a myriad of different...
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BBOF1 is required for sperm motility and male fertility by stabilizing the flagellar axoneme in mice
The sperm flagellum is a specialized type of motile cilium composed of a typical “9 + 2” axonemal structure with peri-axonemal structures, such as...
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Lysine-specific methyltransferase Set7/9 in stemness, differentiation, and development
The enzymes performing protein post-translational modifications (PTMs) form a critical post-translational regulatory circuitry that orchestrates...
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Post-transcriptional regulation in spermatogenesis: all RNA pathways lead to healthy sperm
Multiple RNA pathways are required to produce functional sperm. Here, we review RNA post-transcriptional regulation during spermatogenesis with...
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Nuclear receptor gene expression during early gametogenesis in sea urchin Mesocentrotus nudus gonads
Gametogenesis and the accumulation of nutrients such as proteins progress in sea urchin gonads during their growth. In vertebrate species, these...
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Reproduction-associated pathways in females of gibel carp (Carassius gibelio) shed light on the molecular mechanisms of the coexistence of asexual and sexual reproduction
Gibel carp ( Carassius gibelio ) is a cyprinid fish that originated in eastern Eurasia and is considered as invasive in European freshwater ecosystems....
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What can we learn from mice lacking pro-survival BCL-2 proteins to advance BH3 mimetic drugs for cancer therapy?
In many human cancers the control of apoptosis is dysregulated, for instance as a result of the overexpression of pro-survival BCL-2 proteins. This...
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Mendelian nightmares: the germline-restricted chromosome of songbirds
Germline-restricted chromosomes (GRCs) are accessory chromosomes that occur only in germ cells. They are eliminated from somatic cells through...
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Identification of cell-type specific alternative transcripts in the multicellular alga Volvox carteri
BackgroundCell type specialization is a hallmark of complex multicellular organisms and is usually established through implementation of...
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Cancer Stem Cell Niche and Immune-Active Tumor Microenvironment in Testicular Germ Cell Tumors
Testicular germ cell tumors (TGCTs) represent the most common neoplasia among young men. Management of TGCTs is an excellent example of curative...