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Deregulated DNA ADP-ribosylation impairs telomere replication
The recognition that DNA can be ADP ribosylated provides an unexpected regulatory level of how ADP-ribosylation contributes to genome stability,...
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Replication of DNA
Phenotypic variations are encoded in the language of four nucleotide bases present in the nucleic acid called deoxyribonucleic acid or DNA. This...
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Rolling Circle Replication and Bypass of Damaged Nucleotides
Faithful mitochondrial DNA (mtDNA) replication is critical for the proper function of the oxidative phosphorylation system. Problems with mtDNA...
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Studying Single-Stranded DNA Gaps at Replication Intermediates by Electron Microscopy
Single-stranded DNA gaps are frequent structures that accumulate on newly synthesized DNA under conditions of replication stress. The identification...
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H4S47 O-GlcNAcylation regulates the activation of mammalian replication origins
The transmission and maintenance of genetic information in eukaryotic cells relies on the faithful duplication of the entire genome. In each round of...
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FORK-seq: replication landscape of the Saccharomyces cerevisiae genome by nanopore sequencing
Genome replication map** methods profile cell populations, masking cell-to-cell heterogeneity. Here, we describe FORK-seq, a nanopore sequencing...
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p53 triggers mitochondrial apoptosis following DNA damage-dependent replication stress by the hepatotoxin methyleugenol
Liver cancer is one of the most frequent tumor entities worldwide, which is causally linked to viral infection, fatty liver disease, life-style...
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Human cytomegalovirus hijacks host stress response fueling replication stress and genome instability
Viral infections enhance cancer risk and threaten host genome integrity. Although human cytomegalovirus (HCMV) proteins have been detected in a wide...
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Pyruvate kinase, a metabolic sensor powering glycolysis, drives the metabolic control of DNA replication
BackgroundIn all living organisms, DNA replication is exquisitely regulated in a wide range of growth conditions to achieve timely and accurate...
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The integrated stress response induces R-loops and hinders replication fork progression
The integrated stress response (ISR) allows cells to rapidly shutdown most of their protein synthesis in response to protein misfolding, amino acid...
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A noncanonical response to replication stress protects genome stability through ROS production, in an adaptive manner
Cells are inevitably challenged by low-level/endogenous stresses that do not arrest DNA replication. Here, in human primary cells, we discovered and...
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Pharmacological targeting of MTHFD2 suppresses acute myeloid leukemia by inducing thymidine depletion and replication stress
The folate metabolism enzyme MTHFD2 (methylenetetrahydrofolate dehydrogenase/cyclohydrolase) is consistently overexpressed in cancer but its roles...
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Progerin induces a phenotypic switch in vascular smooth muscle cells and triggers replication stress and an aging-associated secretory signature
Hutchinson-Gilford progeria syndrome is a premature aging disease caused by LMNA gene mutation and the production of a truncated prelamin A protein...
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Replication stress causes delayed mitotic entry and chromosome 12 fragility at the ANKS1B large neuronal gene in human induced pluripotent stem cells
Substantial background level of replication stress is a feature of embryonic and induced pluripotent stem cells (iPSCs), which can predispose to...
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Replisome-cohesin interactions provided by the Tof1-Csm3 and Mrc1 cohesion establishment factors
The chromosomal cohesin complex establishes sister chromatid cohesion during S phase, which forms the basis for faithful segregation of DNA...
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The patterns and participants of parental histone recycling during DNA replication in Saccharomyces cerevisiae
Epigenetic information carried by histone modifications not only reflects the state of gene expression, but also participates in the maintenance of...
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CHK1 inhibitor induced PARylation by targeting PARG causes excessive replication and metabolic stress and overcomes chemoresistance in ovarian cancer
Chemoresistance contributes to the majority of deaths in women with ovarian cancer (OC). Altered DNA repair and metabolic signaling is implicated in...
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PARP inhibition impedes the maturation of nascent DNA strands during DNA replication
Poly(ADP-ribose) polymerase 1 (PARP1) is implicated in the detection and processing of unligated Okazaki fragments and other DNA replication...
