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Hmmr Acts as a Key Regulator in the ADSCs Proliferation and Mitosis
Obesity is a common chronic health problem that requires lifelong efforts for the successful treatment. The proliferation of ADSCs is an essential...
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MiRNA miR-375 as a Multifunctional Regulator of the Cardiovascular System
AbstractMicroRNA (miRNA) miR-375 acts as a multifunctional regulator of the activity of many physiological and pathological cellular processes by...
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The DREAM complex functions as conserved master regulator of somatic DNA-repair capacities
The DNA-repair capacity in somatic cells is limited compared with that in germ cells. It has remained unknown whether not only lesion-type-specific,...
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The recombination regulator RecX negatively regulates heat-stable antifungal factor (HSAF) biosynthesis in Lysobacter enzymogenes
Bacteria often use multiple transcription factors to regulate specific biological processes. Biosynthesis of heat-stable antifungal factor (HSAF) is...
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The proteasome regulator PSME4 modulates proteasome activity and antigen diversity to abrogate antitumor immunity in NSCLC
Immunotherapy revolutionized treatment options in cancer, yet the mechanisms underlying resistance in many patients remain poorly understood....
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The function of mitochondrial regulator LRPPRC in Aedes aegypti and its potential for mosquito control
The yellow fever mosquito, Aedes aegypti , affects the health of millions of people by transmitting arboviruses that cause multiple diseases. Since...
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LMO2 promotes the development of AML through interaction with transcription co-regulator LDB1
One of the characteristics of leukemia is that it contains multiple rearrangements of signal transduction genes and overexpression of non-mutant...
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Regulator of G protein signaling 16 restrains apoptosis in colorectal cancer through disrupting TRAF6-TAB2-TAK1-JNK/p38 MAPK signaling
Colorectal cancer (CRC) remains a major global cause of cancer-related mortality, lacking effective biomarkers and therapeutic targets. Revealing the...
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RBM47 inhibits hepatocellular carcinoma progression by targeting UPF1 as a DNA/RNA regulator
The mechanisms by which the tumor behaviors of hepatocellular carcinoma (HCC) support growth and metastasis remain largely unknown, and it has become...
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IGF2BP2 acts as a m6A modification regulator in laryngeal squamous cell carcinoma through facilitating CDK6 mRNA stabilization
Laryngeal squamous cell carcinoma (LSCC) is one of the most commonly seen cancers in the head and neck region with increasing morbidity and mortality...
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HK2: a potential regulator of osteoarthritis via glycolytic and non-glycolytic pathways
Osteoarthritis (OA) is an age-related chronic degenerative joint disease where the main characteristics include progressive degeneration of...
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SIRT6 is a key regulator of mitochondrial function in the brain
The SIRT6 deacetylase has been implicated in DNA repair, telomere maintenance, glucose and lipid metabolism and, importantly, it has critical roles...
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Melatonin: A Critical Regulator of Plant Growth and Development
Plant growth regulators (PGRs) utilization in the field of agriculture has been widely studied for improving crop quality and yield. Among these...
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RNAi screens identify HES4 as a regulator of redox balance supporting pyrimidine synthesis and tumor growth
NADH/NAD + redox balance is pivotal for cellular metabolism. Systematic identification of NAD(H) redox regulators, although currently lacking, would...
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The protein methyltransferase TrSAM inhibits cellulase gene expression by interacting with the negative regulator ACE1 in Trichoderma reesei
Protein methylation is a commonly posttranslational modification of transcriptional regulators to fine-tune protein function, however, whether this...
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Function of the mdxR gene encoding a novel regulator for carbohydrate metabolism and sporulation in Bacillus subtilis 168
The mdx R gene located upstream of mdx D , encoding a maltogenic amylase, has been annotated as a member of LacI-type transcriptional regulator in Bacillu...
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ANGPTL8 is a negative regulator in pathological cardiac hypertrophy
Pathological cardiac hypertrophy is an independent risk factor for heart failure and is considered a target for the treatment of heart failure....
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PTBP1 as a potential regulator of disease
Polypyrimidine tract-binding protein 1 (PTBP1) is a member of the heterogeneous nuclear ribonucleoprotein (hnRNP) family, which plays a key role in...
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LsSpt23p is a regulator of triacylglycerol synthesis in the oleaginous yeast Lipomyces starkeyi
AbstractThe oleaginous yeast Lipomyces starkeyi has considerable potential in industrial application, since it can accumulate a large amount of...
