Search
Search Results
-
Enzymes Involved in Lipid Digestion
Lipid digestion is a complex process that takes place at the lipid-water interface and involves various lipolytic enzymes present predominantly in...
-
Effect of Sugarcane Jaggery Prepared Using Different Heat Treatment Methods on Lipid and Protein Digestive Enzymes
Lipase and protease inhibitors have received substantial attention in weight-loss drug market and inhibitors from natural sources have been a hotspot...
-
Age-Related Changes in Enzyme Activity in Pancreas, Intestines, and Blood Plasma of Broiler Chickens of the Smena 9 Breed
AbstractThe aim of the study was to study the ontogeny of the digestive organs, the activity of pancreatic enzymes and alkaline phosphatase, and the...
-
Long-Term Light Deprivation Affects Digestive Function in Rats in Ontogeny
AbstractThe effects of light deprivation on age-related dynamics of body weight, food and water intake, as well as the activity of digestive enzymes...
-
Anti-inflammatory and anti-necrotic effects of lectins from Canavalia ensiformis and Canavalia brasiliensis in experimental acute pancreatitis
Lectins isolated from Canavalia ensiformis (ConA) and Canavalia brasiliensis (ConBr) are promising molecules to prevent cell death. Acute...
-
Screening natural product extracts for potential enzyme inhibitors: protocols, and the standardisation of the usage of blanks in α-amylase, α-glucosidase and lipase assays
BackgroundEnzyme assays have widespread applications in drug discovery from plants to natural products. The appropriate use of blanks in enzyme...
-
Seasonal Changes in Body Mass and Activity of Digestive Enzymes in Eptesicus nilssonii (Mammalia: Chiroptera: Vespertilionidae) during Hibernation
AbstractHibernation can be considered as a circannual cycle of feeding and fasting. During winter, the absence of dietary substrates in fat-storing...
-
The efficacy of Plantago asiatica L. water extract on lipid metabolism in a high-fat diet-induced obese C57BL/6 mice
BackgroundPlantago Asiatica L. (PA), belonging to Plantaginaceae, has been reported to have antioxidant and lipid metabolism benefits. Most studies...
-
Screening of Gastrointestinal Lipase Inhibitors Produced by Microorganisms Isolated from Soil and Lake Sediments
Gastrointestinal lipase inhibitors are molecules of pharmaceutical interest due to their use as anti-obesity drugs. In this study, forty strains...
-
Effect of cross-linked enzyme aggregate strategy on characterization of sn-1,3 extracellular lipase from Aspergillus niger GZUF36
AbstractThe sn-1,3 extracellular lipase from Aspergillus niger GZUF36 (EXANL1) has important potential applications. The cross-linked enzyme...
-
Synthesis and Biological Evaluation of Coumarin-Amino Acid-Benzotriazole Conjugates
AbstractObjective: It is aimed to synthesize new amino acid-conjugated coumarin-benzotriazole molecules and to investigate their...
-
Radiation therapy enhances immunotherapy response in microsatellite stable colorectal and pancreatic adenocarcinoma in a phase II trial
Overcoming intrinsic resistance to immune checkpoint blockade for microsatellite stable (MSS) colorectal cancer (CRC) and pancreatic ductal...
-
Identification of DNA methylation-driven genes and construction of a nomogram to predict overall survival in pancreatic cancer
BackgroundThe incidence and mortality of pancreatic cancer (PC) has gradually increased. The aim of this study was to identify survival-related DNA...
-
Physiological effects of nutrients on insulin release by pancreatic beta cells
Obesity and type 2 diabetes (T2D) are growing health problems associated with a loss of insulin sensitivity. Both conditions arise from a long-term...
-
Alternative exon splicing and differential expression in pancreatic islets reveals candidate genes and pathways implicated in early diabetes development
Type 2 diabetes (T2D) has a strong genetic component. Most of the gene variants driving the pathogenesis of T2D seem to target pancreatic β-cell...
-
Natural Products-Based Pancreatic Lipase Inhibitors for Obesity Treatment
Obesity is a multifactorial metabolic disorder, majorly caused due to high-fat diet associated with decline in physical activity. Recent decades have...
-
Identification of promising multi-targeting inhibitors of obesity from Vernonia amygdalina through computational analysis
Vernonia amygdalina , a widely consumed West African food herb, can be a boon in the discovery of safe anti-obesity agents given the extensive reports...
-
Chromatography analysis, in light of vitro antioxidant, antidiabetic, antiobesity, anti-inflammatory, antimicrobial, anticancer, and three-dimensional cancer spheroids’ formation blocking activities of Laurus nobilis aromatic oil from Palestine
Laurus nobilis (LN) has been used throughout the years as a food flavoring and in traditional medicine. The LN leaves have various biological...
-
Mechanisms controlling pancreatic islet cell function in insulin secretion
Metabolic homeostasis in mammals is tightly regulated by the complementary actions of insulin and glucagon. The secretion of these hormones from...
-
In vitro enzyme inhibitory effects of green and brown Australian seaweeds and potential impact on metabolic syndrome
Hypertension, type-2-diabetes (T2D) and obesity are contributory risk factors for the development of metabolic syndrome. Peptides, polyphenols and...
