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Botulinum toxin type A promotes microglial M2 polarization and suppresses chronic constriction injury-induced neuropathic pain through the P2X7 receptor
BackgroundSwitching microglial polarization from the pro-inflammatory M1 phenotype to the anti-inflammatory M2 phenotype represents a novel...
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The P2X7 Receptor in the Maintenance of Cancer Stem Cells, Chemoresistance and Metastasis
Metastasis is the worst prognosis predictor in the clinical course of cancer development. Features of metastatic cancer cells include migratory...
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P2X7 receptor-mediated phenotype switching of pulmonary artery smooth muscle cells in hypoxia
P2X7R activation contributes to the pathogenesis of pulmonary hypertension. However, the molecular mechanism through which P2X7R participates in...
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Silencing NTPDase3 activity rehabilitates the osteogenic commitment of post-menopausal stem cell bone progenitors
BackgroundEndogenously released adenine and uracil nucleotides favour the osteogenic commitment of bone marrow-derived mesenchymal stromal cells...
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Positive allosteric modulation of P2X7 promotes apoptotic cell death over lytic cell death responses in macrophages
P2X7 is an ATP-gated ion channel that is highly expressed by leukocytes, such as macrophages. Here, P2X7 has been demonstrated to be involved in the...
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Detection of Inflammasome Activation by P2X7 Purinoceptor Activation by Determining ASC Oligomerization
The purinoceptor P2X7 is highly expressed in cells of the innate immune system, including monocytes and macrophages. Its activation is a potent...
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Electromagnetic field treatment increases purinergic receptor P2X7 expression and activates its downstream Akt/GSK3β/β-catenin axis in mesenchymal stem cells under osteogenic induction
BackgroundImbalance in bone formation and resorption is a crucial component of the pathological process leading to osteoporosis. Electromagnetic...
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Cx43 hemichannels and panx1 channels contribute to ethanol-induced astrocyte dysfunction and damage
BackgroundAlcohol, a widely abused drug, significantly diminishes life quality, causing chronic diseases and psychiatric issues, with severe health,...
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Enhanced radiation-induced immunogenic cell death activates chimeric antigen receptor T cells by targeting CD39 against glioblastoma
Chimeric antigen receptor (CAR)-T cells directed to solid tumors have been less effective, due in part to the low or lost expression of specific...
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PML at mitochondria-associated membranes governs a trimeric complex with NLRP3 and P2X7R that modulates the tumor immune microenvironment
Uncontrolled inflammatory response arising from the tumor microenvironment (TME) significantly contributes to cancer progression, prompting an...
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RETRACTED ARTICLE: Curcumin amends Ca2+ dysregulation in microglia by suppressing the activation of P2X7 receptor
Curcumin (Cur) is widely used as an anti-inflammation agent and has anti-depression potential. Neuroinflammation mediated by Ca 2+ channel activation...
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Alcohol and e-cigarette damage alveolar-epithelial barrier by activation of P2X7r and provoke brain endothelial injury via extracellular vesicles
BackgroundUse of nicotine containing products like electronic cigarettes (e-Cig) and alcohol are associated with mitochondrial membrane...
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Blocking connexin 43 and its promotion of ATP release from renal tubular epithelial cells ameliorates renal fibrosis
Whether metabolites derived from injured renal tubular epithelial cells (TECs) participate in renal fibrosis is poorly explored. After TEC injury,...
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Immune landscape and redox imbalance during neurological disorders in COVID-19
The outbreak of Coronavirus Disease 2019 (COVID-19) has prompted the scientific community to explore potential treatments or vaccines against severe...
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AMPK-dependent and independent actions of P2X7 in regulation of mitochondrial and lysosomal functions in microglia
BackgroundP2X7 is ubiquitously expressed in myeloid cells and regulates the pathophysiology of inflammatory diseases. Since mitochondrial function in...
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Hematopoiesis Revolves Around the Primordial Evolutional Rhythm of Purinergic Signaling and Innate Immunity – A Journey to the Developmental Roots
A cell's most significant existential task is to survive by ensuring proper metabolism, avoiding harmful stimuli, and adapting to changing...
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Purinergic Signaling and Its Role in Mobilization of Bone Marrow Stem Cells
Mobilization or egress of stem cells from bone marrow (BM) into peripheral blood (PB) is an evolutionary preserved and important mechanism in an...
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RETRACTED ARTICLE: Role of the P2X7 receptor in inflammation-mediated changes in the osteogenesis of periodontal ligament stem cells
Accumulating evidence indicates that the pluripotency of periodontal ligament stem cells (PDLSCs) is compromised under inflammatory conditions;...
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Connexin-43 hemichannels orchestrate NOD-like receptor protein-3 (NLRP3) inflammasome activation and sterile inflammation in tubular injury
BackgroundWithout a viable cure, chronic kidney disease is a global health concern. Inflammatory damage in and around the renal tubules dictates...
