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The crystal structure of SUN1-KASH6 reveals an asymmetric LINC complex architecture compatible with nuclear membrane insertion
The LINC complex transmits cytoskeletal forces into the nucleus to control the structure and movement of nuclear contents. It is formed of nuclear...
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Light-Induced Degradation and Nocturnal Retrograde Movement of Nonexpressor of Pathogenesis-Related Genes 1 from the Chloroplasts to the Nucleus
This study investigated the complex interplay among circadian rhythms, redox balance, and retrograde signaling in plants, focusing on the role of...
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MCL1 nuclear translocation induces chemoresistance in colorectal carcinoma
Colorectal cancer (CRC) is one of the most common and deadliest forms of cancer. Myeloid Cell Leukemia 1 (MCL1), a pro-survival member of the Bcl-2...
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Nuclear transport maintenance of USP22-AR by Importin-7 promotes breast cancer progression
The translocation of biological macromolecules between cytoplasm and nucleus is of great significance to maintain various life processes in both...
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Impacts of Thermal Drainage on Bacterial Diversity and Community Construction in Tianwan Nuclear Power Plant
As one of the low-carbon and high-efficient energy sources, nuclear power is develo** vigorously to alleviate the crisis of global climate warming...
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Pol α-primase dependent nuclear localization of the mammalian CST complex
The human CST complex composed of CTC1, STN1, and TEN1 is critically involved in telomere maintenance and homeostasis. Specifically, CST terminates...
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Spatial and temporal characterization of the rich fraction of plastid DNA present in the nuclear genome of Moringa oleifera reveals unanticipated complexity in NUPTs´ formation
BackgroundBeyond the massive amounts of DNA and genes transferred from the protoorganelle genome to the nucleus during the endosymbiotic event that...
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Melatonin-mediated FKBP4 downregulation protects against stress-induced neuronal mitochondria dysfunctions by blocking nuclear translocation of GR
The physiological crosstalk between glucocorticoid and melatonin maintains neuronal homeostasis in regulating circadian rhythms. However, the...
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Detection of Actin in Nuclear Protein Fraction Isolated from Adult Drosophila Ovary
Much evidence supports the presence of cytoskeletal elements in the nucleus; however, the exact functions of these proteins in the nucleus are still...
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Exploring the surface epitope and nuclear localization analysis of porcine circovirus type 3 capsid protein
Porcine circovirus 3 (PCV3) is a newly emerging virus associated with porcine dermatitis and nephropathy syndrome (PDNS) and reproductive disorders,...
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Super-resolved 3D tracking of cargo transport through nuclear pore complexes
Nuclear pore complexes (NPCs) embedded within the nuclear envelope mediate rapid, selective and bidirectional traffic between the cytoplasm and the...
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Approaches to Determine Nuclear Shape in Cells During Migration Through Collagen Matrices
Fibrillar collagen is an abundant extracellular matrix (ECM) component of interstitial tissues which supports the structure of many organs, including...
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In Vivo Cross-Linking and Co-Immunoprecipitation Procedure to Analyze Nuclear tRNA Export Complexes in Yeast Cells
tRNAs are small noncoding RNAs that are predominantly known for their roles in protein synthesis and also participate in numerous other functions...
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Visualizing Nuclear Pore Complexes in Xenopus Egg Extracts
The nuclear pore complex (NPC) is the conduit in the nuclear envelope through which proteins and RNA are transported between the cytoplasm and...
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The Nuclear Localization Signal of NF-κB p50 Enters the Cells via Syndecan-Mediated Endocytosis and Inhibits NF-κB Activity
It is well established that cationic peptides can enter cells following attachment to polyanionic membrane components. We report that the basic...
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Tonoplast Rafts Stimulate DNA Import into the Mitochondria of Potato Tubers (Solanum tuberosum)
AbstractThe effects of tonoplast and rafts isolated from vacuolar membranes on the import of DNA into mitochondria of potato tubers ( Solanum...
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Rhes, a striatal enriched protein, regulates post-translational small-ubiquitin-like-modifier (SUMO) modification of nuclear proteins and alters gene expression
Rhes (Ras homolog enriched in the striatum), a multifunctional protein that regulates striatal functions associated with motor behaviors and...
