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XBP1-mediated transcriptional regulation of SLC5A1 in human epithelial cells in disease conditions
BackgroundSodium-Glucose cotransporter 1 and 2 (SGLT1/2) belong to the family of glucose transporters, encoded by SLC5A1 and SLC5A2 , respectively....
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Intranasal PAMAM-G3 scavenges cell-free DNA attenuating the allergic airway inflammation
Allergic airway inflammation (AAI), including allergic rhinitis (AR) and allergic asthma, is driven by epithelial barrier dysfunction and type 2...
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Interchromosomal Contacts of rDNA Clusters in Three Human Cell Lines Are Associated with Silencing of Genes Controlling Morphogenesis
AbstractTo study the rDNA contacts with genes in three human cell lines of different origin, we used 4C approach. Our data indicate that the same set...
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Establishment and characterization of immortalized human vocal fold fibroblast cell lines
PurposeVocal fold scarring is abnormal scar tissue in the lamina propria layer of the vocal fold. To facilitate investigation of vocal fold scarring,...
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CircKLHL2 mitigates septic lung injury via circKLHL2-miR-338-3p-ATF6 ceRNA pathway
BackgroundCircular RNAs (circRNAs) are newly identified therapeutic targets for sepsis. CircRNA mmu_circ_0001679 dysregulation is underlying the...
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Long-term differentiating primary human airway epithelial cell cultures: how far are we?
BackgroundHuman airway epithelial (HAE) cellular models are widely used in applicative studies of the airway physiology and disease. In vitro...
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AXL is a candidate receptor for SARS-CoV-2 that promotes infection of pulmonary and bronchial epithelial cells
The current coronavirus disease 2019 (COVID-19) pandemic presents a global public health challenge. The viral pathogen responsible, severe acute...
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Activation of ERK/NF-kB Pathways Contributes to the Inflammatory Response in Epithelial Cells and Macrophages Following Manganese Exposure
Different types of metals, including manganese (Mn), are constantly encountered in various environmental matrices due to natural and anthropogenic...
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Evidence for the critical role of the PI3K signaling pathway in particulate matter-induced dysregulation of the inflammatory mediators COX-2/PGE2 and the associated epithelial barrier protein Filaggrin in the bronchial epithelium
Particulate matter (PM) is an environmental pollutant closely associated with human airway inflammation. However, the molecular mechanisms of...
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The therapeutic effect of stem cells from human exfoliated deciduous teeth on a rat model of tracheal fistula
BackgroundTracheal fistulas (TF) can be dangerous and even fatal in patients. The current treatment is really challenging. Previous studies reported...
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Correlation of Human Microbiome and Immune Functioning with COVID-19 Infections: An Overview
Many microorganisms inhabit the human body, forming a continuous environmental system that regulates human physiology in both health and sickness. As...
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Generation of SARS-CoV-2 Mouse Model by Transient Expression of the Human ACE2 Gene Mediated by Intranasal Administration of AAV-hACE2
One of the most important steps in the development of drugs and vaccines against a new coronavirus infection is their testing on a relevant animal...
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Bronchioalveolar stem cells derived from mouse-induced pluripotent stem cells promote airway epithelium regeneration
BackgroundBronchioalveolar stem cells (BASCs) located at the bronchioalveolar-duct junction (BADJ) are stem cells residing in alveoli and terminal...
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Influence of intersignaling crosstalk on the intracellular localization of YAP/TAZ in lung cells
A cell is a dynamic system in which various processes occur simultaneously. In particular, intra- and intercellular signaling pathway crosstalk has a...
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Exosomal miR-17-5p from human embryonic stem cells prevents pulmonary fibrosis by targeting thrombospondin-2
BackgroundIdiopathic pulmonary fibrosis (IPF) is a chronic, progressive, and irreversible lung disease characterized by pulmonary fibrosis and lung...
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Streptococcus pneumoniae disrupts the structure of the golgi apparatus and subsequent epithelial cytokine response in an H2O2-dependent manner
BackgroundLung infections caused by Streptococcus pneumonia are a global leading cause of death. The reactive oxygen species H 2 O 2 is one of the...
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Reprogrammed lung epithelial cells by decrease of miR-451a in extracellular vesicles contribute to aggravation of pulmonary fibrosis
Extracellular vesicles (EVs) play novel roles in homeostasis through cell-to-cell communication in human airways via transferring miRNAs. However,...
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Mechanistic Approach on the Pulmonary Oxido-Inflammatory Stress Induced by Cobalt Ferrite Nanoparticles in Rats
Cobalt ferrite nanoparticles (CFN) are employed in data storage, imaging, medication administration, and catalysis due to their superparamagnetic...
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Loss of E-cadherin is causal to pathologic changes in chronic lung disease
Epithelial cells line the lung mucosal surface and are the first line of defense against toxic exposures to environmental insults, and their...
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Human cell receptors: potential drug targets to combat COVID-19
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) causes the coronavirus disease 2019 (COVID-19). The World Health Organization (WHO) has...
