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Multivariate Analysis with the R Package mixOmics
The high-dimensional nature of proteomics data presents challenges for statistical analysis and biological interpretation. Multivariate analysis,...
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Tensor methods in data analysis of chromatography/mass spectroscopy-based plant metabolomics
Plant metabolomics is an important research area in plant science. Chemometrics is a useful tool for plant metabolomic data analysis and processing....
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scRNASequest: an ecosystem of scRNA-seq analysis, visualization, and publishing
BackgroundSingle-cell RNA sequencing is a state-of-the-art technology to understand gene expression in complex tissues. With the growing amount of...
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Understanding metric-related pitfalls in image analysis validation
Validation metrics are key for tracking scientific progress and bridging the current chasm between artificial intelligence research and its...
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Metaproteogenomic analysis of saliva samples from Parkinson’s disease patients with cognitive impairment
Cognitive impairment (CI) is very common in patients with Parkinson’s Disease (PD) and progressively develops on a spectrum from mild cognitive...
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Multi-slice spatial transcriptome domain analysis with SpaDo
With the rapid advancements in spatial transcriptome sequencing, multiple tissue slices are now available, enabling the integration and...
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Bioinformatics for wet-lab scientists: practical application in sequencing analysis
BackgroundGenomics data is available to the scientific community after publication of research projects and can be investigated for a multitude of...
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The Socio-Ecological Dimension of Ocean Multi-Use Platforms
A Multi-Use Platform can integrate different maritime activities into a single sea area. We propose an analytical framework to investigate the...
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An analysis of entity normalization evaluation biases in specialized domains
BackgroundEntity normalization is an important information extraction task which has recently gained attention, particularly in the...
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Foodborne Bacterial Pathogen Big Data – Genomic Analysis
Public health authorities attempt to delineate foodborne bacterial outbreaks by identifying connected human cases, sources of contaminated food, and...
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High-Resolution Melting (HRM) analysis of DNA methylation using semiconductor chip-based digital PCR
BackgroundDigital PCR (dPCR) technology allows absolute quantification and detection of disease-associated rare variants, and thus the use of dPCR...
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SIRT1 and ZNF350 as novel biomarkers for osteoporosis: a bioinformatics analysis and experimental validation
BackgroundOsteoporosis (OP) is characterized by bone mass decrease and bone tissue microarchitectural deterioration in bone tissue. This study...
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Pharmacogenomic and Statistical Analysis
Genetic variants can alter response to drugs and other therapeutic interventions. The study of this phenomenon, called pharmacogenomics, is similar...
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Can we trust biomarkers identified using different non-targeted metabolomics platforms? Multi-platform, inter-laboratory comparative metabolomics profiling of lettuce cultivars via UPLC-QTOF-MS
IntroductionData analysis during UPLC-MS non-targeted metabolomics introduces variation as different manufacturers use specific algorithms for data...
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Network pharmacological analysis and experimental study of cucurbitacin B in oral squamous cell carcinoma
Oral squamous cell carcinoma (OSCC) is a malignant tumor with a high incidence and poor prognosis. Cucurbitacin B (CuB) is a tetracyclic triterpenoid...
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Benchmarking long-read RNA-sequencing analysis tools using in silico mixtures
The lack of benchmark data sets with inbuilt ground-truth makes it challenging to compare the performance of existing long-read isoform detection and...
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Analysis and Discussion of the Issue
The analysis and discussion are collectively performed to emphasize the hermeneutical nature of this work’s development. Here, the knowledge base [3]...
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A sco** review on deep learning for next-generation RNA-Seq. data analysis
In the last decade, transcriptome research adopting next-generation sequencing (NGS) technologies has gathered incredible momentum amongst functional...
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Modular tissue-in-a-CUBE platform to model blood-brain barrier (BBB) and brain interaction
With the advent of increasingly sophisticated organoids, there is growing demand for technology to replicate the interactions between multiple...
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Panpipes: a pipeline for multiomic single-cell and spatial transcriptomic data analysis
Single-cell multiomic analysis of the epigenome, transcriptome, and proteome allows for comprehensive characterization of the molecular circuitry...
