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Methionine restriction-induced sulfur deficiency impairs antitumour immunity partially through gut microbiota
Restriction of methionine (MR), a sulfur-containing essential amino acid, has been reported to repress cancer growth and improve therapeutic...
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IL-25 blockade augments antiviral immunity during respiratory virus infection
IL-25 is implicated in the pathogenesis of viral asthma exacerbations. However, the effect of IL-25 on antiviral immunity has yet to be elucidated....
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Uropathogenic Escherichia coli infection-induced epithelial trained immunity impacts urinary tract disease outcome
Previous urinary tract infections (UTIs) can predispose one to future infections; however, the underlying mechanisms affecting recurrence are poorly...
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Streptococcus mutans glutamate binding protein (GlnH) as antigen target for a mucosal anti-caries vaccine
BackgroundIn recent years, several studies have demonstrated that bacterial ABC transporters present relevant antigen targets for the development of...
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Human Amniotic Mesenchymal Stem Cells Alleviate aGVHD after allo-HSCT by Regulating Interactions between Gut Microbiota and Intestinal Immunity
Acute graft-versus-host disease (aGVHD) after allogeneic hematopoietic stem cell transplantation poses one of the most vexing challenges. Gut...
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O-GlcNAc of STING mediates antiviral innate immunity
BackgroundO-GlcNAcylation modification affects multiple physiological and pathophysiolocal functions of cells. Altered O-GlcNAcylation was reported...
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New progress in roles of TGF-β signaling crosstalks in cellular functions, immunity and diseases
The family of secreted dimeric proteins known as the Transforming Growth Factor-β (TGF-β) family plays a critical role in facilitating intercellular...
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The deposition of lanthanum carbonate may activate macrophages to induce gastrointestinal mucosal injury in patients with chronic kidney disease: an in vitro caco-2/THP-1 macrophage coculture model study
The aim of this study was to investigate the effect and possible underlying mechanism of La 2 (CO 3 ) 3 deposition on GI mucosal inflammation. Our results...
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Agaricus subrufescens fermented rye affects the development of intestinal microbiota, local intestinal and innate immunity in suckling-to-nursery pigs
BackgroundAgaricus subrufescens is considered as one of the most important culinary-medicinal mushrooms around the world. It has been widely...
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Mucosal-associated invariant T cells display both pathogenic and protective roles in patients with inflammatory bowel diseases
An important subtype of the innate-like T lymphocytes is mucosal-associated invariant T (MAIT) cells expressing a semi-invariant T cell receptor α...
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Effects of tannic acid on the immunity and intestinal health of broiler chickens with necrotic enteritis infection
BackgroundIn broiler chickens, necrotic enteritis (NE) infection can reduce production performance. Tannic acid has shown great potential as a...
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Proteomics: Unraveling the Cross Talk Between Innate Immunity and Disease Pathophysiology, Diagnostics, and Treatment Options
Inflammation is crucial in diseases, and proteins play a key role in the interplay between innate immunity and pathology. This review explores how...
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Potential links between the microbiota and T cell immunity determine the tumor cell fate
The central role of the microbiota as a pivotal factor regulating anti-tumor immune responses has recently been appreciated. Increasing evidence has...
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Spirulina in fish immunity development: find the black box
In aquaculture studies, Spirulina can be used to replace fish meal in aquafeed to lower the cost of producing fish feed while adding therapeutic and...
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β2-integrins in Immunity: New Roles for Old Players
β2-integrins are adhesion- and mechanoreceptors expressed exclusively on leukocytes. They mediate diverse functions in immunity and are of...
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Functional Aspects of Fish Mucosal Lectins and Crustaceans with Its Applications
Fish skin mucus is an important part of the innate immune system that acts as a first line of defence against infections. Because of the presence of...
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Pathophysiological role of ion channels and transporters in gastrointestinal mucosal diseases
The incidence of gastrointestinal (GI) mucosal diseases, including various types of gastritis, ulcers, inflammatory bowel disease and GI cancer, is...
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Dietary Supplementation of Brevibacillus laterosporus S62-9 Improves Broiler Growth and Immunity by Regulating Cecal Microbiota and Metabolites
Brevibacillus laterosporus has been added as a direct-fed microbiota to chicken. Yet, few studies have reported the effects of B. laterosporus on...
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Pal Affects the Proliferation in Macrophages and Virulence of Brucella, and as Mucosal Adjuvants, Provides an Effective Protection to Mice Against Salmonella Enteritidis
The purpose of this study was to elucidate the roles of peptidoglycan-associated lipoprotein (Pal protein) in the proliferation of Brucella in...
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Effects of dietary mannan oligosaccharides on growth, non-specific immunity, and intestinal health in juveniles of the Japanese sea cucumber (Apostichopus japonicus)
We investigated the beneficial dietary effects of mannan oligosaccharide (MOS) on sea cucumber ( Apostichopus japonicus ) and the optimum dietary level...
