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The association between aging-related monocyte transcriptional networks and comorbidity burden: the Multi-Ethnic Study of Atherosclerosis (MESA)
Translating our knowledge of the biological aging from animal models to humans may give rise to novel approaches of targeting multiple aging-related...
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The Evolution of Mitochondrial Genomes in Fungi
Fungal mitochondrial (mt) genomes (mitogenomes) are diverse and highly variable both at the inter- and intra-species level. While they contain a...
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Mitochondrion-Related Organelles in Free-Living Protists
Mitochondrion-related organelles (MROs) are organelles that have independently evolved from mitochondria in eukaryotes that live in low-oxygen...
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Integrated transcriptomic and proteomic analyses for the characterization of parathyroid oxyphil cells in uremic patients
Chief cells are the predominant cells in parathyroid glands of healthy adults; however, parathyroid oxyphil cells, whose function is unknown,...
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Identification and Expression Analysis of Soybean (Glycine max L.) Dynamin Genes Reveal Their Involvements in Plant Development and Stress Response
Dynamin and dynamin-related proteins (DRPs) are large GTPases that are vital for cytokinesis, endocytosis and multiple biological processes. However,...
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Expression of Synj2bp in mouse liver regulates the extent of wrappER-mitochondria contact to maintain hepatic lipid homeostasis
BackgroundIn mouse liver hepatocytes, nearly half of the surface area of every mitochondrion is covered by wrappER, a wrap**-type of ER that is...
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Brevilaterin B from Brevibacillus laterosporus has selective antitumor activity and induces apoptosis in epidermal cancer
Brevilaterins as antimicrobial peptides (AMPs) secreted by a newly discovered species Brevibacillus laterosporus , had been demonstrated to display...
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Biomolecular Condensation of SH2 Domain-Containing Proteins on Membranes
The plasma membrane serves as an effective platform for signal transduction of membrane receptor pathways. Activation of the T-cell receptor (TCR)...
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Interaction of Hydrogen Sulfide with Phytohormones During Plant Physiological and Stress Conditions
Hydrogen sulfide (H2S) has been identified as the third endogenous gas transmitter after CO (carbon monoxide) and NO (nitric oxide). It is a small,...
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CIP2A induces PKM2 tetramer formation and oxidative phosphorylation in non-small cell lung cancer
Tumor cells are usually considered defective in mitochondrial respiration, but human non-small cell lung cancer (NSCLC) tumor tissues are shown to...
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GSH-Dependent PTMs of Proteins Differ Significantly Between Ontogenetic Phases of Apple Trees
Glutathione (GSH) dependent post-translational modifications (PTMs) of proteins play important roles in plant development, metabolism, and stress...
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Shikonin inhibits neuronal apoptosis via regulating endoplasmic reticulum stress in the rat model of double-level chronic cervical cord compression
Cervical spondylotic myelopathy (CSM) is a clinically symptomatic entity arising from the spinal cord compression by degenerative diseases. Although...
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Two cytoplasmic male sterility phenotypes in beet (Beta vulgaris L.): implications of their simultaneous onset and divergent paths
Cytoplasmic male sterility (CMS) is a mitochondrion-encoded trait specifically affecting anthers. Several male sterility-inducing mitochondrial types...
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The economics of organellar gene loss and endosymbiotic gene transfer
BackgroundThe endosymbiosis of the bacterial progenitors of the mitochondrion and the chloroplast are landmark events in the evolution of life on...
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The Evolutionary Fate of Mitochondrial Aminoacyl-tRNA Synthetases in Amitochondrial Organisms
During the endosymbiotic evolution of mitochondria, the genes for aminoacyl-tRNA synthetases were transferred to the ancestral nucleus. A further...
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A cotransformation system of the unicellular red alga Cyanidioschyzon merolae with blasticidin S deaminase and chloramphenicol acetyltransferase selectable markers
BackgroundThe unicellular red alga Cyanidioschyzon merolae exhibits a very simple cellular and genomic architecture. In addition, procedures for...
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A pair of transporters controls mitochondrial Zn2+ levels to maintain mitochondrial homeostasis
Zn 2+ is required for the activity of many mitochondrial proteins, which regulate mitochondrial dynamics, apoptosis and mitophagy. However, it is not...
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Description of the whole mitochondrial genome of Bhatia longiradiata (Hemiptera, Cicadellidae, Deltocephalinae: Drabescini) and phylogenetic relationship
BackgroundMitochondrial genomes are extremely conserved in genetic processes and valuable molecular indications for phylogenetic and evolutionary...
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Bioprospecting of Metarhizium anisopliae derived crude extract: a ecofriendly insecticide against insect pest
Synthetic pesticides are a considerable issue in both terrestrial and aquatic habitats. Green pesticides derived from fungi, provide an efficient...
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Mitochondrial dynamics, positioning and function mediated by cytoskeletal interactions
The ability of a mitochondrion to undergo fission and fusion, and to be transported and localized within a cell are central not just to proper...
