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Intermittent cyclic mechanical compression promotes endplate chondrocytes degeneration by disturbing Nrf2/PINK1 signaling pathway-dependent mitophagy
An abnormal mechanical load is a pivotal inducer of endplate cartilage degeneration, which subsequently promotes intervertebral disc degeneration....
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Experimental and numerical study on the mechanical behavior of curved glulam structures
In order to investigate the mechanical behavior of curved glulam structures, five-point bending tests were conducted on three typical glulam...
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Complex deformation of cartilage micropellets following mechanical stimulation promotes chondrocyte gene expression
BackgroundArticular cartilage (AC)’s main function is to resist to a stressful mechanical environment, and chondrocytes are responding to mechanical...
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Optimizing artificial meniscus by mechanical stimulation of the chondrocyte-laden acellular meniscus using ad hoc bioreactor
BackgroundTissue engineering focuses on reconstructing the damaged meniscus by mimicking the native meniscus. The application of mechanical loading...
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Debiased ambient vibrations optical coherence elastography to profile cell, organoid and tissue mechanical properties
The role of the mechanical environment in defining tissue function, development and growth has been shown to be fundamental. Assessment of the...
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Mechanical stretch leads to increased caveolin-1 content and mineralization potential in extracellular vesicles from vascular smooth muscle cells
BackgroundHypertension-induced mechanical stress on vascular smooth muscle cells (VSMCs) is a known risk factor for vascular remodeling, including...
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Unconfined Compression Experimental Protocol for Cartilage Explants and Hydrogel Constructs: From Sample Preparation to Mechanical Characterization
Mechanical characterization of articular cartilage and cell-seeded hydrogel constructs is a challenging task due to the complex biphasic behavior of...
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Piezo protein determines stem cell fate by transmitting mechanical signals
Piezo ion channel is a mechanosensitive protein on the cell membrane, which contains Piezo1 and Piezo2. Piezo channels are activated by mechanical...
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Mechanical Characterisation of Polymeric Materials Using Nanoindentation
This chapter describes the mechanical behaviour of polymeric and soft materials through combined computational and experimental studies. Many soft...
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Influence of mechanical and TGF-β3 stimulation on the tenogenic differentiation of tonsil-derived mesenchymal stem cells
BackgroundOrganogenesis from tonsil-derived mesenchymal cells (TMSCs) has been reported, wherein tenogenic markers are expressed depending on the...
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Ferrostatin-1 alleviates the damage of C2C12 myoblast and mouse pelvic floor muscle induced by mechanical trauma
Ferroptosis is a special form of regulated cell death, which is reported to play an important role in a variety of traumatic diseases by promoting...
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Methods for Studying the Effect of Plant Roots on Soil Mechanical Reinforcement: a Review
Due to the need for engineering construction, a large number of man-made slopes are formed, which easy to induce soil erosion and shallow landslide....
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Regression algorithms-driven mechanical properties prediction of angle bracket connection on cross-laminated timber structures
The construction of structures using cross-laminated timber (CLT) has grown in popularity as a result of its environmentally friendly and...
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Shear traction‐separation laws of European beech under mode II loading by 3D digital image correlation
An experimental and numerical study on mode II fracture behaviour of European beech ( Fagus sylvatica L.) in the RL and TL crack propagation systems...
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Mechanical properties of laminated bamboo lumber N-finity according to ISO 23478-2022
This research used the new ISO 23478-2022 standard as a reference for the calculation of mechanical properties of N-finity, and to understand the...
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Mechanical stretching boosts expansion and regeneration of intestinal organoids through fueling stem cell self-renewal
Intestinal organoids, derived from intestinal stem cell self-organization, recapitulate the tissue structures and behaviors of the intestinal...
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Zyxin regulates embryonic stem cell fate by modulating mechanical and biochemical signaling interface
Biochemical signaling and mechano-transduction are both critical in regulating stem cell fate. How crosstalk between mechanical and biochemical cues...
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Compressive mechanical properties of vitrified porcine menisci are superior to frozen and similar to fresh porcine menisci
The common practice of freezing meniscal allograft tissue is limited due to the formation of damaging ice crystals. Vitrification, which eliminates...
