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Human Primordial Germ Cell-Like Cell Induction from Pluripotent Stem Cells by SOX17 and PRDM1 Expression
Human primordial germ cell (PGC) development initiates about 2 weeks after fertilization during embryogenesis. Unique molecular events follow,...
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Replacing Animal Testing with Stem Cell-Organoids : Advantages and Limitations
Various groups including animal protection organizations, medical organizations, research centers, and even federal agencies such as the U.S. Food...
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Mammalian esophageal stratified tissue homeostasis is maintained distinctively by the epithelial pluripotent p63+Sox2+ and p63−Sox2+ cell populations
Self-renewing, damage–repair and differentiation of mammalian stratified squamous epithelia are subject to tissue homeostasis, but the regulation...
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Induction of Primordial Germ Cell-Like Cells from Rat Pluripotent Stem Cells
In vitro induction of primordial germ cell like-cells (PGCLCs) from pluripotent stem cells (PSCs) is a robust method that will contribute to...
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To not love thy neighbor: mechanisms of cell competition in stem cells and beyond
Cell competition describes the process in which cells of greater fitness are capable of sensing and instructing elimination of lesser fit mutant...
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Emerging roles of mitochondrial functions and epigenetic changes in the modulation of stem cell fate
Mitochondria serve as essential organelles that play a key role in regulating stem cell fate. Mitochondrial dysfunction and stem cell exhaustion are...
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Neural stem cell-derived exosomes and regeneration: cell-free therapeutic strategies for traumatic brain injury
Regenerative repair of the brain after traumatic brain injury (TBI) remains an extensive clinical challenge, inspiring intensified interest in...
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Single-cell transcriptome analyses reveal critical regulators of spermatogonial stem cell fate transitions
BackgroundSpermatogonial stem cells (SSCs) are the foundation cells for continual spermatogenesis and germline regeneration in mammals. SSC...
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RNA-Mediated Regulation of Glycolysis in Embryonic Stem Cell Pluripotency and Differentiation
Purpose of ReviewThe maintenance and differentiation of embryonic stem cells are strictly coordinated with their metabolic status. As a core part of...
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SHANK family on stem cell fate and development
SH3 and multiple ankyrin repeat domains protein (SHANK) 1, SHANK2, and SHANK3 encode a family of postsynaptic scaffolding proteins present at...
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Stem Cell-Derived Neural Organoids: From the Origin to Next Generation
The advance of stem cell research has enabled researchers to generate organoids: three-dimensional tissues with biological structures and functions....
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Single-cell sequencing advances in research on mesenchymal stem/stromal cells
Mesenchymal stem/stromal cells (MSCs), originating from the mesoderm, represent a multifunctional stem cell population capable of differentiating...
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Engineered endosymbionts that alter mammalian cell surface marker, cytokine and chemokine expression
Develo** modular tools that direct mammalian cell function and activity through controlled delivery of essential regulators would improve methods...
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A positive feedback between PDIA3P1 and OCT4 promotes the cancer stem cell properties of esophageal squamous cell carcinoma
BackgroundIncreasing evidence has indicated that long non-coding RNAs (lncRNAs) have been proven to regulate esophageal cancer progression. The...
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Exploring distinct properties of endometrial stem cells through advanced single-cell analysis platforms
The endometrium is a dynamic tissue that undergoes cyclic changes in response to ovarian hormones during the menstrual cycle. These changes are...
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Cyclophilin A supports translation of intrinsically disordered proteins and affects haematopoietic stem cell ageing
Loss of protein function is a driving force of ageing. We have identified peptidyl-prolyl isomerase A (PPIA or cyclophilin A) as a dominant chaperone...
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DNA methylation restricts coordinated germline and neural fates in embryonic stem cell differentiation
As embryonic stem cells (ESCs) transition from naive to primed pluripotency during early mammalian development, they acquire high DNA methylation...
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Stem cell homeostasis regulated by hierarchy and neutral competition
Tissue stem cells maintain themselves through self-renewal while constantly supplying differentiating cells. Two distinct models have been proposed...
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Derivation and Primordial Germ Cell Induction of Intermediate Pluripotent Stem Cells
Dynamic pluripotent stem cell (PSC) states are in vitro adaptations of the pluripotency continuum in vivo. Previous studies have generated a number...
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Transcription Factors and Splice Factors—Interconnected Regulators of Stem Cell Differentiation
Purpose of ReviewThe underlying molecular mechanisms that direct stem cell differentiation into fully functional, mature cells remain an area of...
