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Immunomodulatory effects of cannabinoids against viral infections: a review of its potential use in SARS-CoV2 infection
The COVID-19 pandemic is a global health crisis affecting millions of people worldwide. Along with vaccine development, there is also a priority to...
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Identification of Three Key Genes Associated with Hepatocellular Carcinoma Progression Based on Co-expression Analysis
Hepatocellular carcinoma (HCC) is the fifth most common cancer and one of the leading causes of cancer-related death in the world. Due to the...
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Endocannabinoid-Binding Receptors as Drug Targets
Cannabis plant has been used from ancient times with therapeutic purposes for treating human pathologies, but the identification of the cellular and...
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Diacylglycerol lipase alpha promotes hepatocellular carcinoma progression and induces lenvatinib resistance by enhancing YAP activity
As an important hydrolytic enzyme that yields 2-AG and free fatty acids, diacylglycerol lipase alpha (DAGLA) is involved in exacerbating malignant...
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Altered endocannabinoidome bioactive lipid levels accompany reduced DNBS-induced colonic inflammation in germ-free mice
BackgroundGut microbiota are involved in the onset and development of chronic intestinal inflammation. The recently described endocannabinoidome...
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Fatty acid amide hydrolase drives adult mammary gland development by promoting luminal cell differentiation
Mammary gland development occurs primarily in adulthood, undergoing extensive expansion during puberty followed by cycles of functional...
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Dysfunctional endocannabinoid CB1 receptor expression and signaling contribute to skeletal muscle cell toxicity induced by simvastatin
Statins are the most prescribed lipid-lowering agents worldwide. Their use is generally safe, although muscular toxicity occurs in about 1 in 10.000...
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ABX-1431 inhibits the development of endometrial adenocarcinoma and reverses progesterone resistance by targeting MGLL
Endometrial cancer is a common gynecological malignancy. With the onset of EC patients younger, conservative treatment with progesterone has become...
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Transcriptome analysis of metabolic pathways associated with oil accumulation in develo** seed kernels of Styrax tonkinensis, a woody biodiesel species
BackgroundStyrax tonkinensis (Pierre) Craib ex Hartwich has great potential as a woody biodiesel species having seed kernels with high oil content,...
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The cell biology of ferroptosis
Ferroptosis is a non-apoptotic cell death mechanism characterized by iron-dependent membrane lipid peroxidation. Here, we review what is known about...
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Exosome-based nanoimmunotherapy targeting TAMs, a promising strategy for glioma
Exosomes, the cell-derived small extracellular vehicles, play a vital role in intracellular communication by reciprocally transporting DNA, RNA,...
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Hematopoietic Stem Cell Mobilization: Current Collection Approaches, Stem Cell Heterogeneity, and a Proposed New Method for Stem Cell Transplant Conditioning
Hematopoietic stem cells naturally traffic out of their bone marrow niches into the peripheral blood. This natural trafficking process can be...
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Structural properties and role of the endocannabinoid lipases ABHD6 and ABHD12 in lipid signalling and disease
The endocannabinoid (eCB) system is an important part of both the human central nervous system (CNS) and peripheral tissues. It is involved in the...
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Cannabimimetic plants: are they new cannabinoidergic modulators?
Main ConclusionPhytochemicals and secondary metabolites able to interact with the endocannabinoid system (Cannabimimetics) have been recently...
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Lipid droplets: platforms with multiple functions in cancer hallmarks
Lipid droplets (also known as lipid bodies) are lipid-rich, cytoplasmic organelles that play important roles in cell signaling, lipid metabolism,...
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The contrary intracellular and extracellular functions of PEDF in HCC development
Pigment epithelium-derived factor (PEDF), a classic angiogenic inhibitor, has been reported to function as a tumor suppression protein and to...
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In-silico Targets in Neurodegenerative Disorders
Parkinson’s disease (PD), Alzheimer’s disease (AD) are very frequent human neurodegenerative diseases. Their pharmacological treatment has not been...
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Multiple endocannabinoid-mediated mechanisms in the regulation of energy homeostasis in brain and peripheral tissues
The endocannabinoid (eCB) system is widely expressed in many central and peripheral tissues, and is involved in a plethora of physiological...
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A general overview of the multifactorial adaptation to cold: biochemical mechanisms and strategies
Cold environments are more frequent than people think. They include deep oceans, cold lakes, snow, permafrost, sea ice, glaciers, cold soils, cold...
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Fatty acid binding protein 5 suppression attenuates obesity-induced hepatocellular carcinoma by promoting ferroptosis and intratumoral immune rewiring
Due to the rise in overnutrition, the incidence of obesity-induced hepatocellular carcinoma (HCC) will continue to escalate; however, our...
