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Genome-wide analysis of gene expression in human embryonic tooth germ
While numerous genes that play important regulatory roles during tooth development in mice have been identified, little is known about gene...
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Krankheiten des endokrinen Systems
Das Hormonsystem ist mit den elementaren Körperfunktionen so eng verknüpft, dass Defekte des endokrinen Systems zu Krankheiten bis hin zum Tod...
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Heparan-Sulfate 6-O-Sulfotransferase 1-3 (HS6ST1-3)
The functions of heparan sulfate (HS) are involved in various cellular processes such as proliferation, differentiation, adhesion, migration,...
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Growth, Puberty, and Nutritional Disturbances
Oxidative stress can be defined as an imbalance between oxidant and antioxidant status, which occurs in physiological conditions. Of note, the...
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Transcription analysis of the porcine alveolar macrophage response to porcine circovirus type 2
BackgroundPorcine circovirus type 2 (PCV2) is the causal agent of postweaning multisystemic wasting syndrome (PMWS), which has severely impacted the...
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The role of genetics in the establishment and maintenance of the epigenome
Epigenetic mechanisms play an important role in gene regulation during development. DNA methylation, which is probably the most important and...
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Fluorescent In Situ Hybridization of DNA Probes in the Interphase and Metaphase Stages of the Cell Cycle
In the past decade, fluorescent in situ hybridization (FISH) has been used routinely in detecting molecular abnormalities in the interphase and...
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Investigation of Binding Phenomenon of NSP3 and p130Cas Mutants and Their Effect on Cell Signalling
Members of the novel SH2-containing protein (NSP3) and Crk-associated substrate (p130Cas) protein families form a multi-domain signalling platforms...
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Protein- und Peptid-Hormone von Vertebraten
Proteinhormone entstehen wie alle anderen Proteine auch. Damit sie von der Zelle freigesetzt werden, müssen sie allerdings einen erweiterten Weg...
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Domain landscapes of somatic mutations in cancer
BackgroundLarge-scale tumor sequencing projects are now underway to identify genetic mutations that drive tumor initiation and development. Most...
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Mammalian sex determination—insights from humans and mice
Disorders of sex development (DSD) are congenital conditions in which the development of chromosomal, gonadal, or anatomical sex is atypical. Many of...
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A missense mutation in Fgfr1 causes ear and skull defects in hush puppy mice
The hush puppy mouse mutant has been shown previously to have skull and outer, middle, and inner ear defects, and an increase in hearing threshold....
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Frequent gene conversion events between the X and Y homologous chromosomal regions in primates
BackgroundMammalian sex-chromosomes originated from a pair of autosomes. A step-wise cessation of recombination is necessary for the proper...
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Dynamic chromatin states in human ES cells reveal potential regulatory sequences and genes involved in pluripotency
Pluripotency, the ability of a cell to differentiate and give rise to all embryonic lineages, defines a small number of mammalian cell types such as...
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Evidence that prokineticin receptor 2 exists as a dimer in vivo
Prokineticins are proteins that regulate diverse biological processes including gastrointestinal motility, angiogenesis, circadian rhythm, and innate...
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Krankheiten des endokrinen Systems
Das Hormonsystem ist mit den elementaren Körperfunktionen so eng verknüpft, dass Defekte des endokrinen Systems zu Krankheiten bis hin zum Tod...
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Genomic profiling of tumor initiating prostatospheres
BackgroundThe cancer stem cell (CSC) hypothesis proposes that a population of tumor cells bearing stem cell properties is responsible for the origin...
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Effect of serotonin on the formation of neurons producing gonadotropin-releasing hormone in Wistar rats
The effect of serotonin on the formation of neurons producing gonadotropin-releasing hormone (GnRH) during embryogenesis of Wistar rats was studied....