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Model Systems for Exploring the Evolutionary Origins of the Nervous System
The development of nervous systems can be seen as one of the key transitions in animal evolution, allowing the efficient integration of sensory input...
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Exogenous Molecule and Organelle Delivery in Oogenesis
Recent discoveries on the delivery of small- and large-size molecules and organelles to the oocytes/eggs from external sources, such as surrounding...
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Early metazoan cell type diversity and the evolution of multicellular gene regulation
A hallmark of metazoan evolution is the emergence of genomic mechanisms that implement cell-type-specific functions. However, the evolution of...
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Back Through Time: How Cnidarians and Basal Metazoans Shed Light on Ancient Nervous Systems
The origin of neurons and the evolution of the central nervous system (CNS) are not well understood. The physiological nature of primitive neurons...
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Gap junctions and hemichannels: communicating cell death in neurodevelopment and disease
Gap junctions are unique membrane channels that play a significant role in intercellular communication in the develo** and mature central nervous...
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Investigating the genetic and epigenetic basis of big biological questions with the parthenogenetic marbled crayfish: A review and perspectives
In the last 15 years, considerable attempts have been undertaken to develop the obligately parthenogenetic marbled crayfish Procambarus virginalis as...
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Immunohistochemistry and Female Reproductive Toxicology: The Ovary and Mammary Glands
Exposure of women to toxicants represents potentially important consequences for their fertility and on the passage of genetic materials to their...
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Connexins and pannexins in neuronal development and adult neurogenesis
Connexins and pannexins share very similar structures and functions; they also exhibit overlap** expression in many stages of neuronal development....
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Regulation of Skeletal Muscle Myoblast Differentiation and Proliferation by Pannexins
Pannexins are newly discovered channels that are now recognized as mediators of adenosine triphosphate release from several cell types allowing...
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Connexin and pannexin channels in cancer
Communication among cells via direct cell-cell contact by connexin gap junctions, or between cell and extracellular environment via pannexin channels...
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Connexins, Pannexins, and Their Channels in Fibroproliferative Diseases
Cellular and molecular mechanisms of wound healing, tissue repair, and fibrogenesis are established in different organs and are essential for the...
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Drosophila seizure disorders: genetic suppression of seizure susceptibility
Various Drosophila models of human disease have recently received increased interest. The main goal is to uncover the fundamental biological basis...
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Regulation of pannexin and connexin channels and their functional role in skeletal muscles
Myogenic precursor cells express connexins (Cx) and pannexins (Panx), proteins that form different membrane channels involved in cell-cell...
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The phylogenetic position of ctenophores and the origin(s) of nervous systems
Ctenophores have traditionally been treated as eumetazoans, but some recent whole genome studies have revived the idea that they are, rather, the...
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Bioelectric patterning during oogenesis: stage-specific distribution of membrane potentials, intracellular pH and ion-transport mechanisms in Drosophila ovarian follicles
BackgroundBioelectric phenomena have been found to exert influence on various developmental and regenerative processes. Little is known about their...
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Connexin Hemichannels: Methods for Dye Uptake and Leakage
It is now clear that connexin-based, gap junction “hemichannels” in an undocked state are capable of opening and connecting cytoplasm to the...
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Tissue-specific transcriptomics and proteomics of a filarial nematode and its Wolbachia endosymbiont
BackgroundFilarial nematodes cause debilitating human diseases. While treatable, recent evidence suggests drug resistance is develo**,...
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Effects on Channel Properties and Induction of Cell Death Induced by C-terminal Truncations of Pannexin1 Depend on Domain Length
Pannexin1 (Panx1) is an integral membrane protein and known to form multifunctional hexameric channels. Recently, Panx1 was identified to be...
