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Immune profiling of age and adjuvant-specific activation of human blood mononuclear cells in vitro
Vaccination reduces morbidity and mortality due to infections, but efficacy may be limited due to distinct immunogenicity at the extremes of age....
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The expression profile of HAR1A and HAR1B in the peripheral blood cells of multiple sclerosis patients
BackgroundMultiple sclerosis (MS) is a progressive neurodegenerative disease of the central nervous system (CNS) with varying degrees of axonal and...
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Cytogenetic Analysis of the Peripheral Blood Lymphocyte Cultures of a Patient Some Time after Accidental Irradiation Using the Three-Color FISH Method
Abstract —The results of cytogenetic analysis using mainly three-color FISH staining of peripheral blood lymphocyte chromosomes in a single patient...
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Phenoty** of Macrophages in Human Immune System Mice
Human immune system mice, also referred to as humanized mice, are a major research tool for the in vivo study of human immune system function. Upon...
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Characterization of P2X7 Receptors in Human Blood Cells
P2X7 receptors are expressed in different circulating immune cells. Depending on the cell in which they are expressed, their function could vary from...
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Develo** Peripheral Biochemical Biomarkers of Brain Disorders: Insights from Zebrafish Models
AbstractHigh prevalence of human brain disorders necessitates development of the reliable peripheral biomarkers as diagnostic and disease-monitoring...
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Impact of COVID-19 pandemic on cord blood banking and transplantation
Umbilical cord blood is a rich source of hematopoietic stem cells that has been used for transplantation for over 30 years, especially when there is...
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Functionally Active Eosinophil Purification from Peripheral Blood
The choice of isolation technique for human peripheral blood eosinophils contributes to the understanding of clinically relevant data derived from in...
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Cell Composition of Peripheral Blood in Residents of the Techa River Region Exposed to Radiation in Utero
AbstractThe results of a study on the composition of peripheral blood cells in residents of the Techa River region (Chelyabinsk oblast) who were...
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Genotoxicity of a novel thymol bearing oxipropanolamine derivative in human peripheral lymphocytes
[1-(2-isopropyl-5-methylphenoxy)-3-(yridine-3-ylmethylamino)propan-2-ol] is a novel oxipropanolamine derivative. It had been synthesized in a...
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Diurnal and circadian rhythmicity of the human blood transcriptome overlaps with organ- and tissue-specific expression of a non-human primate
BackgroundTwenty-four-hour rhythmicity in mammalian tissues and organs is driven by local circadian oscillators, systemic factors, the central...
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Evaluation of T helper17 as skeletal homeostasis factor in peripheral blood mononuclear cells and T helper cells of end-stage renal disease cases with impaired parathyroid hormone
BackgroundChronic renal failure is mainly connected with high and low parathyroid hormone (PTH) levels and immunological impairments. The present...
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Expression of miR-145 and miR-18b in Peripheral Blood Samples of Head and Neck Cancer Patients
Head and neck squamous cell carcinomas (HNSCC) is one of the most prevalent type of cancer known in Indian population. Studies are needed to identify...
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Oxysterols in Central and Peripheral Synaptic Communication
Cholesterol is a key molecule for synaptic transmission, and both central and peripheral synapses are cholesterol rich. During intense neuronal...
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Mosaic loss of chromosome Y in peripheral blood cells is associated with age-related macular degeneration in men
BackgroundAge-related macular degeneration (AMD) is the leading cause of severe vision loss in patients over 55 years old in the industrialized...
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Dissecting Human Blood Immune Cells Response to Intracellular Infection Using Single-Cell RNA Sequencing
Complex interactions between diverse host immune cells can determine the outcome of pathogen infections. Advances in single-cell RNA sequencing...
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Global DNA methylation profile at LINE-1 repeats and promoter methylation of genes involved in DNA damage response and repair pathways in human peripheral blood mononuclear cells in response to γ-radiation
DNA methylation is an epigenetic mechanism, which plays an important role in gene regulation. The present study evaluated DNA methylation profile of...
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Isolation, characterisation and phagocytic function of human macrophages from human peripheral blood
Macrophages are among the most important cells of the immune system. Among other functions, they take part in almost all defense actions against...
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Single-cell T cell receptor sequencing of paired human atherosclerotic plaques and blood reveals autoimmune-like features of expanded effector T cells
Atherosclerosis is a lipid-driven chronic inflammatory disease; however, whether it can be classified as an autoimmune disease remains unclear. In...
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Transcriptomic comparison of bone marrow CD34 + cells and peripheral blood neutrophils from ET patients with JAK2 or CALR mutations
BackgroundEssential thrombocythemia (ET) is one of the most common types of Ph -negative myeloproliferative neoplasms, an infrequent group of blood...
