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The global gene expression outline of the bovine blastocyst: reflector of environmental conditions and predictor of developmental capacity
BackgroundMorphological evaluation of embryos has been used to screen embryos for transfer. However, the repeatability and accuracy of this method...
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Identification of key modules and driving genes in nonalcoholic fatty liver disease by weighted gene co-expression network analysis
BackgroundNonalcoholic fatty liver disease (NAFLD) is characterized by excessive liver fat deposition, and progresses to liver cirrhosis, and even...
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A map of cis-regulatory modules and constituent transcription factor binding sites in 80% of the mouse genome
BackgroundMouse is probably the most important model organism to study mammal biology and human diseases. A better understanding of the mouse genome...
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CDK7 inhibitor THZ1 inhibits MCL1 synthesis and drives cholangiocarcinoma apoptosis in combination with BCL2/BCL-XL inhibitor ABT-263
Cholangiocarcinoma (CCA) is a fatal disease without effective targeted therapy. We screened a small-molecule library of 116 inhibitors targeting...
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Lineage regulators TFAP2C and NR5A2 function as bipotency activators in totipotent embryos
During the first lineage segregation, a mammalian totipotent embryo differentiates into the inner cell mass (ICM) and trophectoderm (TE). However,...
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A molecular network map of orexin-orexin receptor signaling system
Orexins are excitatory neuropeptides, which are predominantly associated with feeding behavior, sleep-wake cycle and energy homeostasis. The...
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The Impact of Fosfomycin on Gram Negative Infections: A Comprehensive Review
Multidrug-resistant or extended drug resistance has created havoc when it comes to patient treatment, as options are limited because of the spread of...
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Identification of a novel form of caspase-independent cell death triggered by BH3-mimetics in diffuse large B-cell lymphoma cell lines
BH3-mimetics represent promising anti-cancer agents in tumors that rely on the anti-apoptotic function of B-Cell Lymphoma 2 (BCL2) proteins,...
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Regulatory roles of NAT10 in airway epithelial cell function and metabolism in pathological conditions
N-acetyltransferase 10 (NAT10), a nuclear acetyltransferase and a member of the GNAT family, plays critical roles in RNA stability and translation...
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A toxicogenomics study of two chemicals in coffee roasting process
BackgroundRoasted coffee beans are broadly consumed in nearly all classes of the population. 2,3-Butanedione is a food flavor that causes obstructive...
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Mechanism analysis of toxicity of sodium sulfite to human hepatocytes L02
Food additives are widely used in various food products to preserve the taste, color, and other qualities. However, if they are used improperly or...
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Transcriptome profile of spleen tissues from locally-adapted Kenyan pigs (Sus scrofa) experimentally infected with three varying doses of a highly virulent African swine fever virus genotype IX isolate: Ken12/busia.1 (ken-1033)
BackgroundAfrican swine fever (ASF) is a lethal hemorrhagic disease affecting domestic pigs resulting in up to 100% mortality rates caused by the ASF...
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AP-1 activity is a major barrier of human somatic cell reprogramming
Human induced pluripotent stem cells (iPSCs) technology has been widely applied to cell regeneration and disease modeling. However, most mechanism of...
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Differential expression of circRNAs during osteogenic/odontogenic differentiation of stem cells from apical papilla promoted by blue light-emitting diode
BackgroundCircular RNA (circRNA) is a key player in regulating the multidirectional differentiation of stem cells. Previous research by our group...
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Decoding the differentiation of mesenchymal stem cells into mesangial cells at the transcriptomic level
BackgroundMesangial cells play an important role in the glomerulus to provide mechanical support and maintaine efficient ultrafiltration of renal...
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BCL-XL inhibitors enhance the apoptotic efficacy of BRAF inhibitors in BRAFV600E colorectal cancer
Metastatic BRAF V600E colorectal cancer (CRC) carries an extremely poor prognosis and is in urgent need of effective new treatments. While the BRAF V600E...
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Exploring the molecular role of endostatin in diabetic neuropathy
AbstractFor over a decade, diabetic neuropathy has exhibited great emergence in diabetic patients. Though there are numerous impediments in...
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Virtual ChIP-seq: predicting transcription factor binding by learning from the transcriptome
Existing methods for computational prediction of transcription factor (TF) binding sites evaluate genomic regions with similarity to known TF...
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A critical role of AREG for bleomycin-induced skin fibrosis
We report our discovery of an important player in the development of skin fibrosis, a hallmark of scleroderma. Scleroderma is a fibrotic disease,...
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BMP4 enhances anoikis resistance and chemoresistance of breast cancer cells through canonical BMP signaling
Bone morphogenetic proteins (BMPs) regulate cell fate during development and mediate cancer progression. In this study, we investigated the role of...
