Search
Search Results
-
A nutrient-limited screen unmasks rifabutin hyperactivity for extensively drug-resistant Acinetobacter baumannii
Industry screens of large chemical libraries have traditionally relied on rich media to ensure rapid bacterial growth in high-throughput testing. We...
-
Distribution and Clonality of drug-resistant tuberculosis in South Africa
BackgroundStudies have shown that drug-resistant tuberculosis (DR-TB) in South Africa (SA) is clonal and is caused mostly by transmission....
-
Complete genome sequence of an extensively drug resistant (XDR) M. morganii SMM01 isolated from a patient with urinary and fecal incontinence
ObjectiveM. morganii is a gram-negative, non-lactose fermenting and an opportunistic pathogen frequently associated with nosocomial infections....
-
Drug Discovery for Targeting Drug Resistant Bacteria
The alternative approaches for antibacterial drug discovery have a huge potential to develop novel antibacterial agents against multi drug resistant...
-
Multi-drug resistant (MDR), extended spectrum beta-lactamase (ESBL) producing and carbapenem resistant Escherichia coli in rescued Sloth bears (Melursus ursinus), India
The study reports the multi-drug resistant (MDR), extended spectrum beta-lactamase (ESBL) producing and carbapenem resistant Escherichia coli (CRE)...
-
Screening, Characterization and Optimization of Bioactive Peptides with Antibacterial Activities Against Multi-Drug Resistant Pathogens, Produced by Bacillus safensis Strain MK-12.1
Antimicrobial resistance in pathogenic bacteria is increasing rapidly. Therefore, investigation of novel therapeutic agents are essential to combat...
-
Investigating Combination Therapy as a Means to Enhance Activity and Repurpose Antimicrobials
Current clinical practice assumes that a single antibiotic given as a bolus or as a course will successfully treat most infections. In modern...
-
In vitro investigation of relationship between quorum-sensing system genes, biofilm forming ability, and drug resistance in clinical isolates of Pseudomonas aeruginosa
BackgroundPseudomonas aeruginosa is an opportunistic pathogen in the health-care systems and one of the primary causative agents with high mortality...
-
Association of Mutations in gyrA Gene with Resistance to Fluoroquinolones in Clinical Isolates of Multidrug-Resistant Mycobacterium tuberculosis
AbstractThe purpose of the present study was to evaluate the association of mutations inside and outside quinolone-resistance determining region...
-
Assessment of the GenoType MTBDRsl VER 2.0 compared to the phenotypic drug susceptibility testing and whole genome sequencing for the rapid detection of resistance to fluoroquinolone and second-line injectable drugs among rifampicin-resistant Mycobacterium tuberculosis isolates
Molecular techniques have considerable advantages for rapid detection, a reduction of infectiousness, prevention of further resistance development...
-
Asiaticoside A for the modulation of 1-TbAd- a potential target and ligand for extensive drug resistance Mycobacterium tuberculosis
In nature, terpene nucleosides are relatively rare, with 1-tuberculosinyladenosine (1-TbAd) being an exclusive feature of Mycobacterium tuberculosis ...
-
Vanilla modulates the activity of antibiotics and inhibits efflux pumps in drug-resistant Pseudomonas aeruginosa
Vanilla, a popular flavour extracted from Vanilla planifolia pods was tested for its antibiotic modulatory activity against extensively...
-
Association of Mutations in gyrA Gene with Resistance to Fluoroquinolones in Clinical Isolates of Multidrug-Resistant Mycobacterium tuberculosis
AbstractThe purpose of the present study was to evaluate the association of mutations inside and outside quinolone-resistance determining region...
-
Clostridioides difficile and multi-drug-resistant staphylococci in free-living rodents and marsupials in parks of Belo Horizonte, Brazil
The global emergence of antimicrobial resistance (AMR) has become a serious threat to human and animal health. Recent studies have shown that...
-
Identification of novel single nucleotide variants in the drug resistance mechanism of Mycobacterium tuberculosis isolates by whole-genome analysis
BackgroundTuberculosis (TB) represents a major global health challenge. Drug resistance in Mycobacterium tuberculosis (MTB) poses a substantial...
-
Co-production of metallo-β-lactamase and OXA-type β-lactamases in carbapenem-resistant Acinetobacter baumannii clinical isolates in North East India
Carbapenem-resistant Acinetobacter baumannii poses a significant threat to public health globally, especially due to its ability to produce multiple...
-
The Impact of Fosfomycin on Gram Negative Infections: A Comprehensive Review
Multidrug-resistant or extended drug resistance has created havoc when it comes to patient treatment, as options are limited because of the spread of...
-
In vitro and ex vivo activity of the fluoroquinolone DC-159a against mycobacteria
Antimicrobial resistance is a global health problem. In 2021, it was estimated almost half a million of multidrug-resistant tuberculosis (MDR-TB)...
-
The Role of Advanced Therapeutic Techniques to Combat Multi-drug Resistance
A wide variety of microbial pathogens use distinct mechanisms to evade selection pressure and subsequently develop drug resistance towards...
-
Whole genome sequencing reveals candidate genes involving in PAS resistance in M. Tuberculosis isolated from patients in Thailand
Para-amino salicylic acid (PAS) was first reported by Lehmann in 1946 and used for tuberculosis treatment. However, due to its adverse effects, it is...
