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Allele-specific RNA-seq expression profiling of imprinted genes in mouse isogenic pluripotent states
BackgroundGenomic imprinting, resulting in parent-of-origin specific gene expression, plays a critical role in mammalian development. Here, we apply...
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MET/SMAD3/SNAIL circuit mediated by miR-323a-3p is involved in regulating epithelial–mesenchymal transition progression in bladder cancer
Bladder cancer (BCa) is the one of the most common cancers with high incidence, occurrence and low 5-year survival rate. Emerging evidence indicates...
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The roles of lncRNA in hepatic fibrosis
Increasing evidence indicates that long non-coding RNAs (lncRNAs) regulate gene or protein expression; however, their function in the progression of...
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Long non-coding RNA in stem cell pluripotency and lineage commitment: functions and evolutionary conservation
LncRNAs have recently emerged as new and fundamental transcriptional and post-transcriptional regulators acting at multiple levels of gene...
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Identification of genes directly responding to DLK1 signaling in Callipyge sheep
BackgroundIn food animal agriculture, there is a need to identify the mechanisms that can improve the efficiency of muscle growth and protein...
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LncRNA-MEG3 inhibits activation of hepatic stellate cells through SMO protein and miR-212
Activation of hepatic stellate cells (HSCs), a pivotal event in liver fibrosis, is considered as an epithelial–mesenchymal transition (EMT) process....
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The disease-related biological functions of PIWI-interacting RNAs (piRNAs) and underlying molecular mechanisms
More than a decade ago, PIWI-interacting RNA (piRNA) was discovered almost simultaneously by four different research groups. The length of this type...
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Candidate genes and gene markers for the resistance to porcine pleuropneumonia
Actinobacillus ( A .) pleuropneumoniae is one of the most important respiratory pathogens in global pig production. Antimicrobial treatment and...
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CeModule: an integrative framework for discovering regulatory patterns from genomic data in cancer
BackgroundNon-coding RNAs (ncRNAs) are emerging as key regulators and play critical roles in a wide range of tumorigenesis. Recent studies have...
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LncRNAs with miRNAs in regulation of gastric, liver, and colorectal cancers: updates in recent years
Long noncoding RNA (lncRNA) is a kind of RNAi molecule composed of hundreds to thousands of nucleotides. There are several major types of functional...
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JAK/STAT3 regulated global gene expression dynamics during late-stage reprogramming process
BackgroundThe generation of induced pluripotent stem cells (iPSCs) has underdefined mechanisms. In addition, leukemia inhibitory factor (LIF)...
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Genome-wide DNA methylation analysis reveals that mouse chemical iPSCs have closer epigenetic features to mESCs than OSKM-integrated iPSCs
Induced pluripotent stem cells can be derived from somatic cells through ectopic expression of transcription factors or chemical cocktails. Chemical...
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An Insight into Reprogramming Barriers to iPSC Generation
Derivation of induced Pluripotent Stem Cells (iPSCs) by reprogramming somatic cells to a pluripotent state has revolutionized stem cell research....
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RNA-Seq in 296 phased trios provides a high-resolution map of genomic imprinting
BackgroundIdentification of imprinted genes, demonstrating a consistent preference towards the paternal or maternal allelic expression, is important...
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Single-cell RNA-seq reveals the diversity of trophoblast subtypes and patterns of differentiation in the human placenta
The placenta is crucial for a successful pregnancy and the health of both the fetus and the pregnant woman. However, how the human trophoblast...
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Long non-coding RNAs in ischemic stroke
Stroke is one of the leading causes of mortality and disability worldwide. Uncovering the cellular and molecular pathophysiological processes in...
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Insights into the roles of lncRNAs in skeletal and dental diseases
Long noncoding RNAs (lncRNAs) are a class of non-protein-coding transcripts with the length longer than 200 nucleotides. Growing evidence suggests...
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Do Cancer Cell Lines Have Fixed or Fluctuating Stem Cell Phenotypes? – Studies with the NTera2 Cell Line
One of the important questions when studying established cancer cell lines is whether such cells contain a subpopulation of primitive cancer stem...
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Two approaches reveal a new paradigm of ‘switchable or genetics-influenced allele-specific DNA methylation’ with potential in human disease
Imprinted genes are vulnerable to environmental influences during early embryonic development, thereby contributing to the onset of disease in...
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Parent-of-origin effects on quantitative phenotypes in a large Hutterite pedigree
The impact of the parental origin of associated alleles in GWAS has been largely ignored. Yet sequence variants could affect traits differently...
