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Polymorphism profiling of nine high altitude relevant candidate gene loci in acclimatized sojourners and adapted natives
BackgroundSea level sojourners, on ascent to high altitude, undergo acclimatization through integrated physiological processes for defending the body...
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Role of PDLIM4 and c-Src in breast cancer progression
High heterogeneity is characteristic of oncology diseases, often complicating the choice of optimal anticancer treatment. One cancer type may combine...
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Genetic polymorphisms and asthma: findings from a case–control study in the Madeira island population
BackgroundAsthma is a complex disease influenced by multiple genetic and environmental factors. While Madeira has the highest prevalence of asthma in...
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Amyloids: from pathogenesis to function
The term “amyloids” refers to fibrillar protein aggregates with cross-ß structure. They have been a subject of intense scrutiny since the middle of...
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Deletions of chromosomal regulatory boundaries are associated with congenital disease
BackgroundRecent data from genome-wide chromosome conformation capture analysis indicate that the human genome is divided into conserved...
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Filter-free exhaustive odds ratio-based genome-wide interaction approach pinpoints evidence for interaction in the HLA region in psoriasis
BackgroundDeciphering the genetic architecture of complex traits is still a major challenge for human genetics. In most cases, genome-wide...
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Lack of association between the G+2044A polymorphism of interleukin-13 gene and chronic obstructive pulmonary disease: a meta-analysis
Numerous studies have investigated association of interleukin - 13 ( IL - 13 ) G+2044A polymorphism with COPD susceptibility; however, the results were...
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Methylome analysis identifies a Wilms tumor epigenetic biomarker detectable in blood
BackgroundWilms tumor is the most common pediatric renal malignancy and there is a clinical need for a molecular biomarker to assess treatment...
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The association between C-159T polymorphism in CD14 gene and susceptibility to tuberculosis: a meta-analysis
The association between CD14 gene C-159T polymorphism and tuberculosis (TB) susceptibility remains inconclusive. To derive a more precise estimation...
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WinHAP2: an extremely fast haplotype phasing program for long genotype sequences
BackgroundThe haplotype phasing problem tries to screen for phenotype associated genomic variations from millions of candidate data. Most of the...
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Large-scale multiple testing in genome-wide association studies via region-specific hidden Markov models
BackgroundIdentifying genetic variants associated with complex human diseases is a great challenge in genome-wide association studies (GWAS). Single...
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Genetic variants in transforming growth factor-β gene (TGFB1) affect susceptibility to schizophrenia
Immense body of evidence indicates that dysfunction of immune system is implicated in the etiology of schizophrenia. The immune theory of...
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Fluorescent In Situ Hybridization of DNA Probes in the Interphase and Metaphase Stages of the Cell Cycle
In the past decade, fluorescent in situ hybridization (FISH) has been used routinely in detecting molecular abnormalities in the interphase and...
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The clinicopathological significance of lamin A/C, lamin B1 and lamin B receptor mRNA expression in human breast cancer
Lamin A/C (LMNA), lamin B1 (LMNB1) and lamin B receptor (LBR) have key roles in nuclear structural integrity and chromosomal stability. In this...
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Impact of obesity-related genes in Spanish population
BackgroundThe objective was to investigate the association between BMI and single nucleotide polymorphisms previously identified of obesity-related...
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Fine map** of a linkage peak with integration of lipid traits identifies novel coronary artery disease genes on chromosome 5
BackgroundCoronary artery disease (CAD), and one of its intermediate risk factors, dyslipidemia, possess a demonstrable genetic component, although...
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Lysine metabolism in mammalian brain: an update on the importance of recent discoveries
The lysine catabolism pathway differs in adult mammalian brain from that in extracerebral tissues. The saccharopine pathway is the predominant lysine...
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Association of the SNP rs1800925(C/T) in the Interleukin-13 Gene Promoter with Pulmonary Function in Chinese Han Patients with Idiopathic Pulmonary Fibrosis
The present report studied potential association of the rs1800925(C/T) single nucleotide polymorphism (SNP) of the Interleukin (IL)-13 gene promoter...
