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Immunoinformatics analysis and evaluation of recombinant chimeric triple antigen toxoid (r-HAB) against Staphylococcus aureus toxaemia in mouse model
AbstractStaphylococcus aureus is a serious pathogen unleashing its virulence through several classes of exotoxins such as hemolysins and...
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Development of chimeric peptides to facilitate the neutralisation of lipopolysaccharides during bactericidal targeting of multidrug-resistant Escherichia coli
Pathogenic Escherichia coli can cause fatal diarrheal diseases in both animals and humans. However, no antibiotics or antimicrobial peptides (AMPs)...
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An engineered influenza virus to deliver antigens for lung cancer vaccination
The development of cancer neoantigen vaccines that prime the anti-tumor immune responses has been hindered in part by challenges in delivery of...
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Prospect of cell penetrating peptides in stem cell tracking
Stem cell therapy has shown great efficacy in many diseases. However, the treatment mechanism is still unclear, which is a big obstacle for promoting...
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Transcript-specific selective translation by specialized ribosomes bearing genome-encoded heterogeneous rRNAs in V. vulnificus CMCP6
Ribosomes composed of genome-encoded heterogeneous rRNAs are implicated in the rapid adaptation of bacterial cells to environmental changes. A...
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Galanin Peptides Alleviate Myocardial Ischemia/Reperfusion Injury by Reducing Reactive Oxygen Species Formation
Natural and chemically modified N-terminal galanin fragments (WTLNSAGYLLGPHA-OH (G1) and WTLNSAGYLLGPβAH-OH (G2), respectively) reduce functional and...
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Host defence peptides identified in human apolipoprotein B as promising antifungal agents
AbstractTherapeutic options to treat invasive fungal infections are still limited. This makes the development of novel antifungal agents highly...
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Potential “biopeptidal” therapeutics for severe respiratory syndrome coronaviruses: a review of antiviral peptides, viral mechanisms, and prospective needs
Although great advances have been made on large-scale manufacturing of vaccines and antiviral-based drugs, viruses persist as the major cause of...
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Degradation of lipid droplets by chimeric autophagy-tethering compounds
Degrading pathogenic proteins by degrader technologies such as PROTACs (proteolysis-targeting chimeras) provides promising therapeutic strategies,...
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Synthesis of the Antagonist of the GalR2 Galanin Receptor and Studies of Its Biological Activity in Ischemia and Reperfusion of the Rat Heart In Vivo
AbstractThe dose-dependent action of the M871 synthetic peptide antagonist of the GalR2 galanin receptor...
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The new chimeric chiron genes evolved essential roles in zebrafish embryonic development by regulating NAD+ levels
The origination of new genes is important for generating genetic novelties for adaptive evolution and biological diversity. However, their potential...
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Properties and Activity of Peptide Derivatives of ACE2 Cellular Receptor and Their Interaction with SARS-CoV-2 S Protein Receptor-Binding Domain
AbstractThe aim of this work was to design and characterize peptides based on the α-helices h1 and h2 of the ACE2 receptor, forming the interaction...
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Antigenic Peptide-Thioredoxin Fusion Chimeras for In Vitro Stimulus of CD4+ TCR+ Jurkat T Cells
AbstractStudy of CD4 + T cell response and T cell receptor (TCR) specificity is crucial for understanding etiology of immune-mediated diseases and...
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Molecular Dynamics Study of the Human Beta-defensins 2 and 3 Chimeric Peptides with the Cell Membrane Model of Pseudomonas aeruginosa
Pseudomonas aeruginosa is a unique microorganism among the antibiotic-resistant microbial pathogens. Among the various therapeutic approaches,...
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Systematic identification and comparative analysis of lysine succinylation between the green and white parts of chimeric leaves of Ananas comosus var. bracteatus
BackgroundLysine succinylation, an important protein posttranslational modification (PTM), is widespread and conservative. The regulatory functions...
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Generation of allogenic chimera carrying mutations in PDX1 and TP53 genes via phytohemagglutinin-mediated blastomere aggregation in pigs
The generation of genetically engineered pig models that develop pancreas-specific tumors has the potential to advance studies and our understanding...
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Antiviral activities and applications of ribosomally synthesized and post-translationally modified peptides (RiPPs)
The emergence and re-emergence of viral epidemics and the risks of antiviral drug resistance are a serious threat to global public health. New...
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Functional expression and purification of tailor-made chimeric endolysin with the broad antibacterial spectrum
Develo** chimeric lysins with a wide lytic spectrum is important in fighting against Gram-negative pathogenic bacteria. In the present work, a...
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The Types and Applications of Peptibodies
Peptides as drugs are a promising therapeutic method. Peptides modulate diverse biological processes and are synthesized with high purity. Due to...
