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Identification of 12 hub genes associated to the pathogenesis of osteoporosis based on microarray and single-cell RNA sequencing data
Osteoporosis is a common disease, especially among the elderly. This study aimed to comprehensively examine the roles of immune microenvironment in...
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CytoSIP: an annotated structural atlas for interactions involving cytokines or cytokine receptors
Therapeutic agents targeting cytokine-cytokine receptor (CK-CKR) interactions lead to the disruption in cellular signaling and are effective in...
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The roles of Eph receptors, neuropilin-1, P2X7, and CD147 in COVID-19-associated neurodegenerative diseases: inflammasome and JaK inhibitors as potential promising therapies
The novel coronavirus disease 2019 (COVID-19) pandemic has spread worldwide, and finding a safe therapeutic strategy and effective vaccine is...
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Endothelial Cell–Matrix Interactions in Angiogenesis and Vessel Homeostasis: A Focus on Laminins and Their Integrin Receptors
Integrin-mediated interaction of cells with proteins present in the extracellular matrix and basement membranes direct many cellular processes...
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Enhanced tyrosine sulfation is associated with chronic kidney disease-related atherosclerosis
BackgroundChronic kidney disease (CKD) accelerates atherosclerosis, but the mechanisms remain unclear. Tyrosine sulfation has been recognized as a...
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A machine learning model for classifying G-protein-coupled receptors as agonists or antagonists
BackgroundG-protein coupled receptors (GPCRs) sense and transmit extracellular signals into the intracellular machinery by regulating G proteins....
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Design and Self Assembly of Tri-Terpene Peptide Conjugates and Their Interactions with EGFR and EGFR Mutant Receptors: An In Silico and In Vitro Study
In this work, we designed new terpenoid-peptide conjugates to target the epidermal growth factor receptor (EGFR) and its double mutant EGFR...
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Single-cell profiling reveals the trajectory of FOLR2-expressing tumor-associated macrophages to regulatory T cells in the progression of lung adenocarcinoma
An immunosuppressive microenvironment enriched with regulatory CD4 + T lymphocytes (Tregs) facilitates the progression of lung adenocarcinoma (LUAD)....
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Functional molecular switches of mammalian G protein-coupled bitter-taste receptors
Bitter taste receptors (TAS2Rs) are a poorly understood subgroup of G protein-coupled receptors (GPCRs). The experimental structure of these...
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Involvement of CXCL12/CXCR4 axis in colorectal cancer: a mini-review
Migration of metastatic tumor cells is similar to the traffic of leukocytes and has been reported that can be guided by chemokines and their...
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Omental macrophages secrete chemokine ligands that promote ovarian cancer colonization of the omentum via CCR1
The omentum is the most common site of ovarian cancer metastasis. Immune cell clusters called milky spots are found throughout the omentum. It is...
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Alpha 7 nicotinic acetylcholine receptors signaling boosts cell-cell interactions in macrophages effecting anti-inflammatory and organ protection
Activation of the cholinergic anti-inflammatory pathway (CAP) via vagus nerve stimulation has been shown to improve acute kidney injury in rodent...
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Chemokine (C-X-C motif) ligand 1 maintains the immune surveillance function of natural killer cells via the PDK2/mTOR signaling pathway
Chemokine (C-X-C motif) ligand 1 (CXCL1) is mainly expressed on neutrophils and macrophages and has neutrophil chemoattractant activity. However,...
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A subpopulation of green turtle suprabasal epidermal cells are Langerin+ and migrate under in vitro stimulation of the chemokine CCL21
Dendritic cells form the link between the innate and adaptative immune response, particularly on mucosal and epidermal surfaces. The Langerhans, an...
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Analysis of CCR2 splice variant expression patterns and functional properties
BackgroundC–C motif chemokine receptor 2 (CCR2), the main receptor for monocyte chemoattractant protein-1 (MCP-1), is expressed on immune cells,...
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A review of non-prostanoid, eicosanoid receptors: expression, characterization, regulation, and mechanism of action
Eicosanoid signaling controls a wide range of biological processes from blood pressure homeostasis to inflammation and resolution thereof to the...
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Interaction of Tau with the chemokine receptor, CX3CR1 and its effect on microglial activation, migration and proliferation
Alzheimer’s disease (AD) is a neurodegenerative disease that leads to progressive loss of memory and dementia. The pathological hallmarks of AD...
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Structural insights into ligand recognition and subtype selectivity of the human melanocortin-3 and melanocortin-5 receptors
Members of the melanocortin receptor (MCR) family that recognize different melanocortin peptides mediate a broad spectrum of cellular processes...
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Microarray analysis reveals the potential molecular mechanism of Lp299v in stable coronary atherosclerotic disease
A growing body of evidence has confirmed that inflammatory mechanisms are involved in the formation and treatment of coronary atherosclerotic disease...
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The significance of the SDF-1/CXCR4 signaling pathway in the normal development
Chemokines are chemoattractants that can regulate cell movement and adhesion. SDF-1 [stromal cell-derived factor-1 (SDF-1)] is a homeostatic CXC...
