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Long non-coding RNA DARS-AS1 promotes tumor progression by directly suppressing PACT-mediated cellular stress
Cancer cells evolve various mechanisms to overcome cellular stresses and maintain progression. Protein kinase R (PKR) and its protein activator...
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Proteostasis, Proteodynamics and Cellular Aging
During each cell’s life, myriads of different, necessary proteins are manufactured and serve as interacting structural and/or functional elements...
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Differential mitochondrial bioenergetics and cellular resilience in astrocytes, hepatocytes, and fibroblasts from aging baboons
Biological resilience, broadly defined as the ability to recover from an acute challenge and return to homeostasis, is of growing importance to the...
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Plant responses to heat stress
The heat stress response is characterized by inhibition of normal transcription and translation, higher expression of heat shock proteins (hsps) and...
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Cellular Blood Flow Modeling with HemoCell
Many of the intriguing properties of blood originate from its cellular nature. Bulk effects, such as viscosity, depend on the local shear rates and...
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Cellular metabolic pathways of aging in dogs: could p53 and SIRT1 be at play?
Aging and cancer seem to be closely associated, such that cancer is generally considered a disease of the elderly in both humans and dogs....
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Lipid droplets: a cellular organelle vital in cancer cells
Lipid droplets (LDs) are cellular organelles comprising a core of neutral lipids (glycerides, sterols) encased within a single phospholipid membrane,...
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Sprouty1 is a broad mediator of cellular senescence
Genes of the Sprouty family (Spry1-4) restrain signaling by certain receptor tyrosine kinases. Consequently, these genes participate in several...
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Gasotransmitters Signaling in Plant Abiotic Stress Gasotransmitters in Adaptation of Plants to Abiotic Stress
This book deals with the gasotransmitters signaling in redox reactions and homeostasis for the adaptation of plants to unfavorable abiotic stress...
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Insights into plant regeneration: cellular pathways and DNA methylation dynamics
Plants, known for their immobility, employ various mechanisms against stress and damage. A prominent feature is the formation of callus tissue—a...
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Severe cellular stress activates apoptosis independently of p53 in osteosarcoma
Apoptosis induced by doxorubicin, bortezomib, or paclitaxel, targeting DNA, 26S proteasome, and microtubules respectively, was assessed in two...
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Heavy metal signalling in plants: linking cellular and organismic responses
Heavy metals are required in plants as essential micronutrients or act as toxic compounds. How do plants perceive heavy metals and which signalling...
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High-resolution assessment of multidimensional cellular mechanics using label-free refractive-index traction force microscopy
A critical requirement for studying cell mechanics is three-dimensional assessment of cellular shapes and forces with high spatiotemporal resolution....
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Understanding the Involvement of Gasotransmitters in the Regulation of Cellular Signalling and Adaptive Responses Against UV-B Mediated Oxidative Stress in Plants
Due to their sessile and immobile nature, plants continuously encounter multifarious abiotic stress factors including solar UV-radiation, changing...
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Lysosomes as coordinators of cellular catabolism, metabolic signalling and organ physiology
Every cell must satisfy basic requirements for nutrient sensing, utilization and recycling through macromolecular breakdown to coordinate programmes...
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Strategies of Molecular Signal Integration for Optimized Plant Acclimation to Stress Combinations
Plant growth and survival in their natural environment require versatile mitigation of diverse threats. The task is especially challenging due to the...
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Oxidized SOD1 accelerates cellular senescence in neural stem cells
BackgroundNeural stem cells (NSCs), especially human NSCs, undergo cellular senescence characterized by an irreversible proliferation arrest and loss...
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Punicalagin relieves lipotoxic injuries on pancreatic β-cells via regulating the oxidative stress and endoplasmic reticulum stress-mediated apoptosis
Cellular toxicity of hyperlipidemia has been long considered a major cause of various intractable disease such as diabetes. Discovering lipotoxicity...
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Antioxidant Defensive Mechanisms to Regulate Cellular Redox Homeostatic Balance
The genesis of reactive oxygen species (ROS) is a ubiquitous consequence faced by the aerobic life on exposure to biotic and abiotic stress. The...
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Glucosinolates, isothiocyanates, and their role in the regulation of autophagy and cellular function
Autophagy is a cellular degradation process important for the maintenance of cytoplasmic integrity which can be upregulated in response to stress...
