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SLC43A2 and NFκB signaling pathway regulate methionine/cystine restriction-induced ferroptosis in esophageal squamous cell carcinoma via a feedback loop
Studies have indicated dietary restriction of methionine/cystine provided a therapeutic benefit in diseases such as cancer. However, the molecular...
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Tumour cell apoptosis modulates the colorectal cancer immune microenvironment via interleukin-8-dependent neutrophil recruitment
Sporadic apoptosis of tumour cells is a commonly observed feature of colorectal cancer (CRC) and strongly correlates with adverse patient prognosis....
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Impairment of IgG Fc functions promotes tumor progression and suppresses NK cell antitumor actions
Natural killer (NK) cells mediate antibody dependent cytotoxic killing of cancer cells via cross-linking FcγR on NK cells with IgG-Fc. Studies have...
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Intramuscular delivery of neural crest stem cell spheroids enhances neuromuscular regeneration after denervation injury
BackgroundMuscle denervation from trauma and motor neuron disease causes disabling morbidities. A limiting step in functional recovery is the...
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Combustion behavior of furfurylated wood in the presence of montmorillonite and its char characteristics
To investigate the combustion behavior of furfurylated wood in the presence of montmorillonite (MMT) and its char properties, original, MMT-treated,...
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Increased levels of villus-derived exosomal miR-29a-3p in normal pregnancy than uRPL patients suppresses decidual NK cell production of interferon-γ and exerts a therapeutic effect in abortion-prone mice
ObjectiveRecurrent pregnancy loss (RPL) patients have higher absolute numbers of decidual natural killer (dNK) cells with elevated intracellular...
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Cultured Pig Thyroid Follicular Cells: Electrical Evaluation of Epithelial Integrity
Thyroid epithelial cells organize as enclosed follicles containing thyroid hormone precursor, iodinated thyroglobulin, with lumina bordered by the...
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Oxethazaine inhibits esophageal squamous cell carcinoma proliferation and metastasis by targeting aurora kinase A
Esophageal squamous cell carcinoma (ESCC), a malignant neoplasm with high incidence, is a severe global public health threat. The current modalities...
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Serine 727 phosphorylation is necessary to induce the STAT3-mediated transcription of LINC00184 in oesophageal squamous cell carcinoma
LINC00184 has been suggested to be associated with cancer prognosis and has been implicated in cancer glycolysis; however, its role in oesophageal...
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Bacterial induction of B cell senescence promotes age-related changes in the gut microbiota
The elucidation of the mechanisms of ageing and the identification of methods to control it have long been anticipated. Recently, two factors...
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Triple-negative breast cancer cells rely on kinase-independent functions of CDK8 to evade NK-cell-mediated tumor surveillance
Triple-negative breast cancer (TNBC) is an aggressive malignant disease that is responsible for approximately 15% of breast cancers. The standard of...
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De novo and cell line models of human mammary cell transformation reveal an essential role for Yb-1 in multiple stages of human breast cancer
Breast cancer heterogeneity has made it challenging to identify mechanisms critical to the initial stages of their genesis in vivo. Here, we sought...
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Combinatorial targeting of multiple myeloma by complementing T cell engaging antibody fragments
Bispecific T cell engaging antibodies (BiTEs) address tumor associated antigens that are over-expressed on cancer but that can also be found on...
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An unsupervised method for physical cell interaction profiling of complex tissues
Cellular identity in complex multicellular organisms is determined in part by the physical organization of cells. However, large-scale investigation...
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Transplantation of Gelatin Microspheres Loaded with Wharton's Jelly Derived Mesenchymal Stem Cells Facilitates Cartilage Repair in Mice
Background:Knee osteoarthritis (KOA) is a prevalent chronic joint disease caused by various factors. Mesenchymal stem cells (MSCs) therapy is an...
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Endoplasmic reticulum stress modulates the fate of lung resident mesenchymal stem cell to myofibroblast via C/EBP homologous protein during pulmonary fibrosis
BackgroundAs a fatal interstitial lung disease, idiopathic pulmonary fibrosis (IPF) was characterized by the insidious proliferation of extracellular...
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Tumor-derived exosomal miR-3157-3p promotes angiogenesis, vascular permeability and metastasis by targeting TIMP/KLF2 in non-small cell lung cancer
Metastasis is the main cause of death in patients with advanced lung cancer. The exosomes released by cancer cells create tumor microenvironment, and...
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Furfurylation result of Radiata pine depends on the solvent
Furfurylation is a modification technique that improves many wood properties. The wood is first impregnated with furfuryl alcohol (FA) diluted in a...
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HK1 from hepatic stellate cell–derived extracellular vesicles promotes progression of hepatocellular carcinoma
Extracellular vesicles play crucial roles in intercellular communication in the tumor microenvironment. Here we demonstrate that in hepatic fibrosis,...
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Anatomical, scanning electron microscopy, histological and histochemical studies of the orbital glands of the Egyptian agama Trapelus mutabilis
BackgroundThe orbital gland of the group agama (Agamidae) is not well-studied. Here is a first description of anatomical and histological studies on...
