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Insights into taxadiene synthase catalysis and promiscuity facilitated by mutability landscape and molecular dynamics
Main conclusionProtein modeling, carbocation docking, and molecular dynamics along with structure-based mutability landscapes provided insight into...
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ATP Synthase: Energy Generating Machinery in Cells
ATP synthase is an enzyme that drives the formation of ATP from ADP and Pi. It is a molecular rotary motor composed of F1 and Fo subunits and couples...
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The mitochondrial Ahi1/GR participates the regulation on mtDNA copy numbers and brain ATP levels and modulates depressive behaviors in mice
BackgroundPrevious studies have shown that depression is often accompanied by an increase in mtDNA copy number and a decrease in ATP levels; however,...
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Excess intracellular ATP causes neuropathic pain following spinal cord injury
Intractable neuropathic pain following spinal cord injury (NP-SCI) reduces a patient’s quality of life. Excessive release of ATP into the...
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Live Cell Imaging of ATP Dynamics in Plant Cells
Adenosine triphosphate (ATP) is a central metabolite that functions as the energy currency in a living cell. Therefore, visualizing cellular ATP...
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Characterization and complete genome analysis of Bacillus velezensis CB6 revealed ATP synthase subunit α against foodborne pathogens
Given the serious threat of foodborne multidrug-resistant bacteria to animals and humans, finding an effective antibacterial compound has always been...
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Isochorismate synthase is required for phylloquinone, but not salicylic acid biosynthesis in rice
Salicylic acid (SA) is a phytohormone required for plant growth and defense signaling. There are two major SA biosynthesis pathways in plants: the...
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Trehalose 6-phosphate synthase gene rdtps1 contributes to thermal acclimation in Rhyzopertha dominica
BackgroundThe lesser grain borer ( Rhyzopertha dominica ), a worldwide primary pest of stored grain, causes serious economic losses and threatens...
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Positive Selection in the Chloroplastic ATP-Synthase β-Subunit and Its Relation to Virulence Factors
The most paradigmatic examples of molecular evolution under positive selection involve genes related to the immune system. Recently, different...
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Gene Identification, expression analysis and molecular docking of ATP sulfurylase in the selenization pathway of Cardamine hu**shanensis
BackgroundATP sulfurylase (ATPS) is a crucial enzyme for the selenate assimilation pathway in plants.
ResultsIn this study, genome-wide and...
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Bacterial FOF1 ATP: Nanomotor for ATP Synthesis and Hydrolysis and Mechanism of Interaction with the Macrolide Antibiotic Oligomycin A
AbstractFOF1-ATP synthase is a highly conserved enzyme of eukaryotic or bacterial cells. This enzyme contains eight species of various subunits in...
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Discovery and Study of Transmembrane Rotary Ion-Translocating Nano-Motors: F-ATPase/Synthase of Mitochondria/Bacteria and V-ATPase of Eukaryotic Cells
AbstractThis review discusses the history of discovery and study of the operation of the two rotary ion-translocating ATPase nano-motors: (i)...
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Effect of downregulated citrate synthase on oxidative phosphorylation signaling pathway in HEI-OC1 cells
BackgroundCitrate Synthase ( Cs ) gene mutation (locus ahL4 ) has been found to play an important role in progressive hearing loss of A/J mice. HEI-OC1...
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The maize ATP-binding cassette (ABC) transporter ZmMRPA6 confers cold and salt stress tolerance in plants
Key messageZmMRPA6 was cloned and characterized as the first ATP-binding cassette (ABC) transporter in maize to be proven to participate in cold and...
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Pps1, phosphatidylserine synthase, regulates the salt stress response in Schizosaccharomyces pombe
Phosphatidylserine (PS) is important for maintaining growth, cytoskeleton, and various functions in yeast; however, its role in stress responses is...
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High-intensity interval training induces lactylation of fatty acid synthase to inhibit lipid synthesis
BackgroundThe aim of study was to observe the effect of increased lactate levels during high-intensity interval training (HIIT) on protein...
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Microglial hexokinase 2 deficiency increases ATP generation through lipid metabolism leading to β-amyloid clearance
Microglial cells consume adenosine triphosphate (ATP) during phagocytosis to clear neurotoxic β-amyloid in Alzheimer’s disease (AD). However, the...
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Neurobehavioral dysfunction in a mouse model of Down syndrome: upregulation of cystathionine β-synthase, H2S overproduction, altered protein persulfidation, synaptic dysfunction, endoplasmic reticulum stress, and autophagy
Down syndrome (DS) is a genetic condition where the person is born with an extra chromosome 21. DS is associated with accelerated aging; people with...
