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Monocyte Chemoattractant Protein-1 stimulates the differentiation of rat stem and progenitor Leydig cells during regeneration
BackgroundMonocyte chemoattractant protein-1(MCP-1) is a chemokine secreted by Leydig cells and peritubular myoid cells in the rat testis. Its role...
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Identification and functional characterization of a novel aldo–keto reductase from Aloe vera
Main conclusionThe present investigation profoundly asserted the catalytic potential of plant-based aldo-ketoreductase, postulating its role in...
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Identification of the Hub Genes Linked to Lead (IV)-Induced Spleen Toxicity Using the Rat Model
Exposure to lead (Pb) has harmful effects on the organs of both humans and animals, particularly the spleen. However, the precise mechanisms through...
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Glucocorticoid activates STAT3 and NF-κB synergistically with inflammatory cytokines to enhance the anti-inflammatory factor TSG6 expression in mesenchymal stem/stromal cells
Glucocorticoid (GC) is essential for maintaining immune homeostasis. While GC is known to regulate the expression of genes related to inflammation in...
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Recombinant Extracellular Cholesterol Oxidase from Nocardioides simplex
AbstractCholesterol oxidase is a highly demanded enzyme used in medicine, pharmacy, agriculture, chemistry, and biotechnology. It catalyzes oxidation...
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Fungal phthalimidines-chemodiversity, bioactivity and biosynthesis of a unique class of natural products
A wide range of natural products important for the engineering and drug design of pharmaceuticals comprise largely of nitrogen-based heterocycles....
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Garcinia kola: a critical review on chemistry and pharmacology of an important West African medicinal plant
Garcinia kola Heckel (Clusiaceae) is a tree indigenous to West and Central Africa. All plant parts, but especially the seeds, are of value in local...
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Rapid Differentiation of Human Embryonic Stem Cells into Testosterone-Producing Leydig Cell-Like Cells In vitro
Background:Leydig cells (LCs) are testicular somatic cells that are the major producers of testosterone in males. Testosterone is essential for male...
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Wie setzt man eine chemische Reaktion in Gang, auch dann, wenn sie eigentlich nicht will?
Sowohl die Kinetik von Enzymen als auch die Thermodynamik von biochemischen Reaktionen soll in diesem Kapitel angesprochen werden. Der Grill ist mit...
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Bone morphogenetic protein 4 inhibits rat stem/progenitor Leydig cell development and regeneration via SMAD-dependent and SMAD-independent signaling
Bone morphogenetic protein 4 (BMP4) is an important member of the transforming growth factor-β superfamily. BMP4 is expressed in the Leydig cell...
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Transcriptomic Responses and Larval-Stage Growth of Protandrous Yellowfin Seabream (Acanthopagrus Latus) to Different Polyethylene Microplastics Exposure
Polyethylene microplastics (PE-MPs) were widespread in the marine environment; thus, their influences on marine hermaphroditic fish cannot be...
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Dunaliella Ds-26-16 acts as a global regulator to enhance salt tolerance by coordinating multiple responses in Arabidopsis seedlings
Main conclusionBased on phenotypic, physiological and proteomic analysis, the possible mechanism by which Ds-26-16 regulates salt tolerance in Arabidopsis...
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Prenatal ethanol exposure and changes in fetal neuroendocrine metabolic programming
Prenatal ethanol exposure (PEE) (mainly through maternal alcohol consumption) has become widespread. However, studies suggest that it can cause...
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HB-EGF upregulates StAR expression and stimulates progesterone production through ERK1/2 signaling in human granulosa-lutein cells
BackgroundHeparin-binding epidermal growth factor-like growth factor (HB-EGF) belongs to the epidermal growth factor (EGF) family of growth factors....
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Rerouting phytosterol degradation pathway for directed androst-1,4-diene-3,17-dione microbial bioconversion
AbstractSteroid-based drugs are now mainly produced by the microbial transformation of phytosterol, and a two-step bioprocess is adopted to reach...
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Proteomic identification of lipid-bodies-associated proteins in maize seeds
Seeds store lipids in the form of lipid bodies (LBs) for germination and early seedling growth. LBs can be easily isolated by the established...
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Gene expression of male pathway genes sox9 and amh during early sex differentiation in a reptile departs from the classical amniote model
BackgroundSex determination is the process whereby the bipotential embryonic gonads become committed to differentiate into testes or ovaries. In...
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Lost in promiscuity? An evolutionary and biochemical evaluation of HSD10 function in cardiolipin metabolism
Multifunctional proteins are challenging as it can be difficult to confirm pathomechanisms associated with disease-causing genetic variants. The...
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Bile acid-mediated signaling in cholestatic liver diseases
Chronic cholestatic liver diseases, such as primary biliary cholangitis (PBC) and primary sclerosing cholangitis (PSC), are associated with bile...
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Gut microbiota affects the estrus return of sows by regulating the metabolism of sex steroid hormones
BackgroundSex hormones play important roles in the estrus return of post-weaning sows. Previous studies have demonstrated a complex and...
