Search
Search Results
-
Alternative splicing coupled to nonsense-mediated decay coordinates downregulation of non-neuronal genes in develo** mouse neurons
BackgroundThe functional coupling between alternative pre-mRNA splicing (AS) and the mRNA quality control mechanism called nonsense-mediated decay...
-
The Effect and Mechanism of POSTN and Its Alternative Splicing on the Apoptosis of Myocardial Cells in Acute Myocardial Infarction: A Study in Vitro
Our study aimed to investigate key molecular targets in the pathogenesis of AMI, and provide new strategy for the treatment. In this work, the...
-
RNA-binding proteins potentially regulate the alternative splicing of apoptotic genes during knee osteoarthritis progression
BackgroundAlternative splicing (AS) is a principal mode of genetic regulation and one of the most widely used mechanisms to generate structurally and...
-
Bud31-mediated alternative splicing is required for spermatogonial stem cell self-renewal and differentiation
Alternative splicing (AS) is tightly regulated during cell differentiation and development. AS events are prevalent in the testis, but the splicing...
-
Insights into sweet potato SR proteins: from evolution to species-specific expression and alternative splicing
Main conclusionSR proteins from sweet potato have conserved functional domains and similar gene structures as that of Arabidopsis and rice in...
-
Liver RBFOX2 regulates cholesterol homeostasis via Scarb1 alternative splicing in mice
RNA alternative splicing (AS) expands the regulatory potential of eukaryotic genomes. The mechanisms regulating liver-specific AS profiles and their...
-
The StuA Transcription Factor and Alternative Splicing Mechanisms Drive the Levels of MAPK Hog1 Transcripts in the Dermatophyte Trichophyton rubrum
Trichophyton rubrum is a human fungal pathogen that causes dermatophytosis, an infection that affects keratinized tissues. Integrated molecular...
-
Two-Color Fluorescent Reporters for Analysis of Alternative Splicing
Alternative splicing is a key layer of gene regulation that is frequently modulated in a spatiotemporal manner. As such, it is a major goal to...
-
RBX1 regulates PKM alternative splicing to facilitate anaplastic thyroid carcinoma metastasis and aerobic glycolysis by destroying the SMAR1/HDAC6 complex
BackgroundAnaplastic thyroid carcinoma (ATC) is one of the most aggressive malignancies, frequently accompanied by metastasis and aerobic glycolysis....
-
Unveiling the Role of Dynamic Alternative Splicing Modulation After Infestation with Sea Lice (Caligus rogercresseyi) in Atlantic Salmon
Sea lice are pathogenic marine ectoparasite copepods that represent a severe risk to the worldwide salmon industry. Several transcriptomic...
-
c-Mpl-del, a c-Mpl alternative splicing isoform, promotes AMKL progression and chemoresistance
Acute megakaryocytic leukemia (AMKL) is a clinically heterogeneous subtype of acute myeloid leukemia characterized by unrestricted megakaryoblast...
-
Pre-mRNA splicing order is predetermined and maintains splicing fidelity across multi-intronic transcripts
Combinatorially, intron excision within a given nascent transcript could proceed down any of thousands of paths, each of which would expose different...
-
Alternative splicing during fruit development among fleshy fruits
BackgroundAlternative splicing (AS) is an important mechanism of posttranscriptional modification and dynamically regulates multiple physiological...
-
Comprehensive profiling of alternative splicing landscape during secondary dormancy in oilseed rape (Brassica napus L.)
Alternative splicing is a general mechanism that regulates gene expression at the post-transcriptional level, which increases the transcriptomic...
-
Targeting Alternative Splicing for Therapeutic Interventions
Targeting of pre-mRNA splicing has yielded a rich variety of strategies for altering gene expression as a treatment for disease. The search for...
-
Identification of alternative splicing events related to fatty liver formation in duck using full-length transcripts
BackgroundNon-alcoholic fatty liver disease (NAFLD) is one of most common diseases in the world. Recently, alternative splicing (AS) has been...
-
PlaASDB: a comprehensive database of plant alternative splicing events in response to stress
BackgroundAlternative splicing (AS) is a co-transcriptional regulatory mechanism of plants in response to environmental stress. However, the role of...
-
LINC00924-induced fatty acid metabolic reprogramming facilitates gastric cancer peritoneal metastasis via hnRNPC-regulated alternative splicing of Mnk2
The molecular mechanism underlying gastric cancer (GC) peritoneal metastasis (PM) remains unclear. Here, we identified LINC00924 as a GC PM-related...
-
Annexin A2 (ANXA2) regulates the transcription and alternative splicing of inflammatory genes in renal tubular epithelial cells
BackgroundRenal inflammation plays a crucial role during the progression of Chronic kidney disease (CKD), but there is limited research on hub genes...
