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Design, bioactivity and mechanism of N′-phenyl pyridylcarbohydrazides with broad-spectrum antifungal activity
Succinate dehydrogenase inhibitors (SDHIs) as one of the fastest-growing fungicide categories for plant protection. In this study, a series of N ′-phen...
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Novel flavonol derivatives containing benzoxazole as potential antiviral agents: design, synthesis, and biological evaluation
A series of flavonol derivatives containing benzoxazole were designed and synthesized, and the structures of all the target compounds were determined...
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Synthesis of Morpholine Linked Indole-1,2,3-triazole Hybrids as In Vitro Tubulin Polymerization Inhibiting Agents
AbstractObjective: Synthesis of some new some new morpholine linked indole-1,2,3-triazole hybrids and evaluation of their anti-cancer activity. ...
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Optimal 13C NMR investigation of intrinsically disordered proteins at 1.2 GHz
Nuclear magnetic resonance (NMR) spectroscopy is a powerful technique for characterizing biomolecules such as proteins and nucleic acids at atomic...
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Copper (II) complex supported on magnetic nanoparticles as a novel nanocatalyst for the synthesis of imidazo[1,2-a]pyridines
Research on the synthesis of imidazo[1,2-a]pyridines has gained great importance among synthetic chemists because there have been numerous reports of...
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An efficient one-pot synthesis and docking studies of bioactive new antiproliferative dispiro[oxindole/acenaphthylenone‒benzofuranone] pyrrolidine scaffolds
A new and efficient method has been developed to synthesize dispiro[oxindole/acenaphthylenone-benzofuranone]pyrrolidine compounds. This is done by...
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Design, synthesis and bioactivity evaluation of novel monomethyl auristatin F analogues
Monomethyl auristatin F (MMAF), a synthetic analogue of the natural compound dolastatin 10, has garnered significant attention in cancer research due...
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Development of novel nitric oxide production inhibitors based on the 7H-pyrrolo[2,3-d]pyrimidine scaffold
Nitric oxide (NO), the smallest signaling molecule known, can be excessively produced by overexpressed inducible nitric oxide synthase (iNOS), and...
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Synthesis of Some New Coumarin-thiazolidine-2,4-dione-1,2,3-triazole Hybrids as Tubulin Targeting Anti-Lung Cancer Agents
AbstractObjective: Synthesis of some new coumarin-thiazolidine-2,4-dione-1,2,3-triazoles and evaluation of their anti-lung cancer activity. Methods: ...
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Design, synthesis, and evaluation of thiazolecarboxamide derivatives as stimulator of interferon gene inhibitors
Stimulator of interferon gene (STING) plays critical roles in the cytoplasmic DNA-sensing pathway and in the induction of inflammatory response....
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Design and synthesis of new quinazolinone derivatives: investigation of antimicrobial and biofilm inhibition effects
New quinazolin-4-ones 9–32 were synthesized in an attempt to overcome the life-threatening antibiotic resistance phenomenon. The antimicrobial...
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Synthesis and Biological Evaluation of 2-(6-Phenylimidazo[2,1-b][1,3,4]thiadiazol-2-yl)benzo[d]thiazole Derivatives as EGFR Targeting Anticancer Agents
Abstractctive: Benzothiazole and imidazo[2,1- b ][1,3,4]thiadiazole derivatives are the most important pharmacophores and intermediates for making...
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Design, synthesis, and structure–activity relationship study of novel plinabulin derivatives as anti-tumor agents based on the co-crystal structure
Plinabulin, a 2, 5-diketopiperazine-type tubulin inhibitor derived from marine natural products, is currently undergoing Phase III clinical trials...
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Design, Synthesis, In Silico Molecular Docking, ADMET Studies, and Biological Evaluation of Novel Substituted Diphenyl Pyrazole Incorporated 1,2,3-Triazolyl Benzene Sulfonamides
AbstractObjective: A novel triazolyl benzene sulfonamides were synthesized and evaluated for antitubercular and anticancer activity. Methods: Our...
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Design, synthesis and biological evaluation of 5H-[1,2,4]triazino[5,6-b]indole derivatives bearing a pyridinocycloalkyl moiety as iron chelators
The avidity of cancer cells for iron highlights the potential for iron chelators to be used in cancer therapy. Herein, we designed and synthesized a...
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Effective Microwave-Assisted Synthesis of 2-Chloro-5,6-dimethyl-3-(((substituted-benzylidene)hydrazono)methyl)-quinoline and Its Biological Assessment
Abstractective: The quinoline scaffold is widely acknowledged as a critical framework for the development of novel pharmaceuticals. The derivatives...
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Synthesis, Antibacterial, and Antifungal Evaluation of New Class of Pyrimido[4,5-d]pyrimidine, Pyrazolo[3,4-d]pyrimidine, and Pyrimido[4,5-b]quinoline Derived from α,α-Ketene Dithioacetals as fused Five and Six-membered Heterocycle Derivatives
AbstractA novel heterocyclic compounds containing pyrimido[4,5- d ]pyrimidine ( IIIa–IIIb ) and ( IVa–IVb ), pyrazolo[3,4- d ]pyrimidine ( Va'–Ve' ) and ( VIa'–VIe'...
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Synthesis and Biological Evaluation of Fused [1,2,3]Triazolo[4ʹ,5ʹ:4,5]pyrido[2,3-d]pyrimidine Linked 1,2,3-Triazolesas Potent EGFR Targeting Anticancer Agents
AbstractUsing 1-(4-nitrophenyl)-4,5-dihydro-1 H -[1,2,3]triazolo[4ʹ,5ʹ:4,5]pyrido[2,3- d ]pyrimidine and various aryl azides, we developed and...
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Synthesis of Novel 2-((3-(Benzofuran-2-yl)-1-phenyl-1H-pyrazol-4-yl)methylene)hydrazinyl-4-phenylthiazole: Potent EGFR Targeting Anticancer Agents
AbstractObjective: Benzofurans, fused pyrazole systems, and thiazole moieties are the most important pharmacophores and intermediates for making...
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Metabolites from a global regulator engineered strain of Pseudomonas lurida and their inducement of trap formation in Arthrobotrys oligospora
BackgroundPlant parasitic nematodes (PPNs) cause serious harm to agricultural production. Nematode-trap** fungi (NTF) can produce traps to capture...
