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The biosynthesis and functional roles of methylated nucleosides in eukaryotic mRNA
Modified nucleosides are present in mRNA of all eukaryotes, albeit at much lower levels than in other RNA moieties such as rRNA, tRNA, and snRNA....
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Checkpoint and Coordinated Cellular Responses to DNA Damage
The DNA damage and replication checkpoints are signaling mechanisms that regulate and coordinate cellular responses to genotoxic conditions. The...
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Survey of Enzymological Data on ODCase
OMP decarboxylase (ODCase) has been the subject of enzymological, structural, and theoretical studies for several decades, yet its highly proficient...
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Introduction: Regulatory processes, an emerging feature in intracellular membrane traffic
The subject of this volume is the molecular mechanism of the intracellular membrane trafficking, a central eukaryotic cell biological process. In the...
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Biosynthesis and function of tRNA wobble modifications
Post-transcriptional modifications at the first (wobble) position of the tRNA anticodon participate in the precise decoding of the genetic code that...
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Genome evolution: Lessons from Genolevures
In the past years, yeast genome-sequencing programs have been widely developed. Two of them, namely Genolevures I and II, were devoted to the...
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Scientific and technical challenges for systems biology
Systems biology is an emergent discipline, yet can be rooted back almost a century when pioneering thoughts on system-oriented views were discussed....
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Conserved ribosomal RNA modification and their putative roles in ribosome biogenesis and translation
rRNA maturation requires extensive covalent modifications of riboses and bases. These modifications concern exclusively the most conserved regions of...
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Biosynthesis and function of 1-methyladenosine in transfer RNA
Determining the function of single nucleotide modifications in tRNA has been elusive because so many tRNA modification enzymes are not essential for...
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From isolation to integration, a systems biology approach for building the Silicon Cell
In the last decade, the field now commonly referred to as systems biology has developed rapidly. With the sequencing of whole genomes and the...
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Systems biology of apoptosis
New approaches are required for the mathematical modelling and system identification of complex signal transduction networks, which are characterized...
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Crystallographic Studies of Native and Mutant Orotidine 5′phosphate Decarboxylases
This review aims to use the results of an approach combining crystallographic structure analysis with mutational studies as a framework for the...
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Integrated transcriptomics and metabolomics provide insights into the biosynthesis of militarine in the cell suspension culture system of Bletilla striata
Militarine is a monomer molecule with abundant and distinctive biological properties, also the lead member of secondary metabolites in Bletilla striata ...
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Gold nanoparticles-based biosensors: pioneering solutions for bacterial and viral pathogen detection—a comprehensive review
Gold Nanoparticles (AuNPs) have gained significant attention in biosensor development due to their unique physical, chemical, and optical properties....
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Escin’s phytochemistry and pharmacy: biosynthesis, chemistry, synergism and novel activities
Drug resistance against antibiotics and cancer chemotherapeutics are one of the pressing issues before contemporary medicine. One way to overcome...
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Effect of competition intensity and neighbor identity on architectural traits of Fagus sylvatica
Key messageDifferences in architectural traits of European beech saplings submitted to different levels of competition intensity and neighborhood...
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Folding of newly synthesised proteins in the endoplasmic reticulum
The endoplasmic reticulum (ER) is a membranous compartment that can be found within any nucleated eukaryotic cell. Its job is to oversee the...
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Structural features of fungal genomes
Eighteen fungal genomes have been sequenced to date from a variety of taxonomic groups, with fifteen Ascomycota, two Basidomycota and one...
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Biological Markers for Anoxia in the Photic Zone of the Water Column
In this chapter we review the current state of knowledge on the occurrence of anoxic conditions in the water column of past depositional systems...
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Controls on the Carbon Isotopic Compositions of Lipids in Marine Environments
Organic carbon isotopes have long been used to study modern and ancient biogeochemical processes. Controls on the isotopic composition of organic...