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Gut microbiota-derived butyrate restores impaired regulatory T cells in patients with AChR myasthenia gravis via mTOR-mediated autophagy
More than 80% of patients with myasthenia gravis (MG) are positive for anti-acetylcholine receptor (AChR) antibodies. Regulatory T cells (Tregs)...
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Butyrate potentiates Enterococcus faecalis lipoteichoic acid-induced inflammasome activation via histone deacetylase inhibition
Enterococcus faecalis , a Gram-positive opportunistic pathogen having lipoteichoic acid (LTA) as a major virulence factor, is closely associated with...
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Postbiotic butyrate: role and its effects for being a potential drug and biomarker to pancreatic cancer
Postbiotics are produced by microbes and have recently gained importance in the field of oncology due to their beneficial effects to the host,...
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Effect of dietary supplementation with sodium butyrate and tributyrin on the growth performance and intestinal microbiota of Pacific white shrimp (Litopenaeus vannamei)
A 6-week feeding trial was conducted to investigate the effect of adding sodium butyrate (SB) and tributyrin (TBT) on the growth performance,...
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Two intestinal microbiota-derived metabolites, deoxycholic acid and butyrate, synergize to enhance host defense peptide synthesis and alleviate necrotic enteritis
BackgroundNecrotic enteritis (NE) is a major enteric disease in poultry, yet effective mitigation strategies remain elusive. Deoxycholic acid (DCA)...
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Butyrate in combination with forskolin alleviates necrotic enteritis, increases feed efficiency, and improves carcass composition of broilers
BackgroundThe emergence of antimicrobial resistance has necessitated the development of effective alternatives to antibiotics for livestock and...
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Supplementation with sodium butyrate improves growth and antioxidant function in dairy calves before weaning
BackgroundThere is increasing research interest in using short-chain fatty acids (SCFAs) including butyrate as potential alternatives to antibiotic...
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Synergistic Inhibitory Effect of Lactobacillus Cell Lysates and Butyrate on Poly I:C-Induced IL-8 Production in Human Intestinal Epithelial Cells
Postbiotics include cell lysates (CLs), enzymes, cell wall fragments, and heat-killed bacteria derived from probiotics. Although postbiotics are...
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Dietary sodium butyrate supplementation attenuates intestinal inflammatory response and improves gut microbiota composition in largemouth bass (Micropterus salmoides) fed with a high soybean meal diet
The study aimed to investigate the effects of dietary sodium butyrate (NaBT) supplementation on the gut health of largemouth bass ( Micropterus...
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Stimulating Anaerobic Degradation of Butyrate via Syntrophomonas wolfei and Geobacter sulfurreducens: Characteristics and Mechanism
Anaerobic digestion (AD) has been widely applied for the degradation of organic wastewater due to its advantages of high-load operation and energy...
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Protective effects of sodium butyrate on rotavirus inducing endoplasmic reticulum stress-mediated apoptosis via PERK-eIF2α signaling pathway in IPEC-J2 cells
BackgroundRotavirus (RV) is a major pathogen that causes severe gastroenteritis in infants and young animals. Endoplasmic reticulum (ER) stress and...
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Lactobacillus plantarum-derived metabolites sensitize the tumor-suppressive effects of butyrate by regulating the functional expression of SMCT1 in 5-FU-resistant colorectal cancer cells
A critical obstacle to the successful treatment of colorectal cancer (CRC) is chemoresistance. Chemoresistant CRC cells contribute to treatment...
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Analysis of the Butyrate-Producing Pathway in Porphyromonas gingivalis
Butyrate is one of the most harmful metabolic end products found in the oral cavity. Thus, it would be important to characterize the enzymes...
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Lactobacillus rhamnosus KBL2290 Ameliorates Gut Inflammation in a Mouse Model of Dextran Sulfate Sodium-Induced Colitis
Ulcerative colitis, a major form of inflammatory bowel disease (IBD) associated with chronic colonic inflammation, may be induced via overreactive...
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Sodium nitrate has no detrimental effect on milk fatty acid profile and rumen bacterial population in water buffaloes
This study evaluated the influence of dietary sodium nitrate on ruminal fermentation profiles, milk production and composition, microbial populations...
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Sodium butyrate inhibits high cholesterol-induced neuronal amyloidogenesis by modulating NRF2 stabilization-mediated ROS levels: involvement of NOX2 and SOD1
The gut–brain axis is currently being studied as a therapeutic strategy for neurological diseases, especially Alzheimer’s disease (AD). Obesity...
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Transcriptome analysis reveals a molecular understanding of nicotinamide and butyrate sodium on meat quality of broilers under high stocking density
BackgroundIn recent years, increased attention has been focused on breast muscle yield and meat quality in poultry production. Supplementation with...
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Dynamic control of the distribution of carbon flux between cell growth and butyrate biosynthesis in Escherichia coli
AbstractMicrobial cell factories offer an economic and environmentally friendly method for the biosynthesis of acetyl-CoA-derived chemicals. However,...
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Sodium butyrate modulates gut microbiota and immune response in colorectal cancer liver metastatic mice
Colorectal cancer (CRC) liver metastasis (CLM) is the leading death cause of CRC patients, but there is no satisfied approach to treat CLM. Gut...
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Tubacin Histone Deacetylase 6 Inhibitor Produced α-Tubulin Acetylation, Cell Cycle Arrest, Aging, and Suppression of Migration of Mouse Fibroblasts Transformed by E1A and cHa-ras Oncogenes
AbstractInhibitors of histone
- deacetylase activity are widely used to block cancer cell proliferation in clinical trials in vivo and in experiments...