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Improving the accumulation of recombinant human serum albumin (HSA) in transgenic tobacco plants by fusion with the N-terminal proline-rich domain of γ-zein (Zera)
Plants have long played a major role in human health as a source of herbal remedies. Recently, transgenic plants have become convenient bioreactors...
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Recombinant Strains of Oncolytic Vaccinia Virus for Cancer Immunotherapy
AbstractCancer virotherapy is an alternative therapeutic approach based on the viruses that selectively infect and kill tumor cells. Vaccinia...
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Human Epithelial Protein SLURP-2 as a Prototype of Drugs for Wound Healing
AbstractObjective: Wound healing is a complex process based on the regulation of proliferation and migration of epithelial cells. Chronic wounds are...
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Matrix metalloproteinase-10 protects against acute kidney injury by augmenting epidermal growth factor receptor signaling
Matrix metalloproteinase-10 (MMP-10) is a zinc-dependent endopeptidase involved in regulating a wide range of biologic processes, such as apoptosis,...
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EGFL7 Secreted By Human Bone Mesenchymal Stem Cells Promotes Osteoblast Differentiation Partly Via Downregulation Of Notch1-Hes1 Signaling Pathway
BackgroundEpidermal growth factor-like domain protein 7 (EGFL7) is a secreted protein that is differentially expressed in the bone microenvironment;...
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Directed differentiation of human pluripotent stem cells into epidermal stem and progenitor cells
BackgroundPluripotent stem cells (PSCs) produced by somatic cell reprogramming self-renew in culture and can differentiate into any cell type,...
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Epidermal Growth Factor Receptor: Key to Selective Intracellular Delivery
AbstractEpidermal growth factor receptor (EGFR) is an integral surface protein mediating cellular response to a number of growth factors. Its...
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HB-EGF upregulates StAR expression and stimulates progesterone production through ERK1/2 signaling in human granulosa-lutein cells
BackgroundHeparin-binding epidermal growth factor-like growth factor (HB-EGF) belongs to the epidermal growth factor (EGF) family of growth factors....
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Effect of Octamer-Binding Transcription Factor 4 Overexpression on the Neural Induction of Human Dental Pulp Stem Cells
Stem cell-based therapy is a potential alternative strategy for brain repair, with neural stem cells (NSC) presenting as the most promising...
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Visualization of Differentiated Cells in 3D and 2D Intestinal Organoid Cultures
The intestinal epithelium maintains self-renewal and differentiation capacities via coordination of key signaling pathways, including the Wnt, bone... -
Blockade of stromal cell-derived factor-1 signaling disturbs the invasiveness of human extravillous trophoblast cells
BackgroundThe invasion of trophoblast cells into the maternal uterine decidua is crucial for the formation of the placenta and establishment of...
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Nicotiana hairy roots for recombinant protein expression, where to start? A systematic review
BackgroundHairy roots are a plant-tissue culture raised by Rhizobium rhizogenes infection (formerly known as Agrobacterium rhizogenes ). Nowadays,...
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HAI-1 is required for the novel role of FGFBP1 in maintenance of cell morphology and F-actin rearrangement in human keratinocytes
Formation and maintenance of skin barrier function require tightly controlled membrane-associated proteolysis, in which the integral membrane...
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Crosstalk between purinergic receptor P2Y11 and chemokine receptor CXCR7 is regulated by CXCR4 in human macrophages
P2Y 11 is a G protein-coupled ATP receptor that activates IL-1 receptor (IL-1R) in a cyclic AMP dependent manner. In human macrophages, P2Y 11 /IL-1R...
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Circular dorsal ruffles disturb the growth factor-induced PI3K-AKT pathway in hepatocellular carcinoma Hep3B cells
BackgroundCircular dorsal ruffles (CDRs) are rounded membrane ruffles induced on the dorsal surfaces of cells stimulated by growth factors (GF). They...
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Knockdown expression of a MYB-related transcription factor gene, OsMYBS2, enhances production of recombinant proteins in rice suspension cells
BackgroundTransgenic plant suspension cells show economic potential for the production of valuable bioproducts. The sugar starvation-inducible rice αAmy3...
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Dendritic epidermal T cells secreting exosomes promote the proliferation of epidermal stem cells to enhance wound re-epithelialization
BackgroundEfficient re-epithelialization is important for successful skin wound healing. The proportion of epidermal stem cells (EpSCs) and dendritic...
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Genetics of Growth Control
All animals develop from a fertilized zygote. The development of a zygote depends on cell proliferation for generating tissues and organs. Abnormal... -
The wheat NAC transcription factor TaNAC22 enhances cadmium stress tolerance in wheat
Cadmium (Cd) pollution is a main problem in food production as it reduces crop yield and threatens human health. However, the pathway of Cd...
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Increased phosphatase regenerating liver-1 trigger vascular remodeling in injured ovary via platelet-derived growth factor signaling pathway
BackgroundVascular abnormalities in the ovary cause infertility accompanied by ovarian insufficiency due to a microenvironment of barren ovarian...