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Senescence and Cell Cycle Control
In response to various stresses, such as telomere shortening during continuous proliferation, oxidative stress, DNA damage and aberrant oncogene...
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An oncolytic virus delivering tumor-irrelevant bystander T cell epitopes induces anti-tumor immunity and potentiates cancer immunotherapy
Tumor-specific T cells are crucial in anti-tumor immunity and act as targets for cancer immunotherapies. However, these cells are numerically scarce...
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Evolution and developmental plasticity of lung structure in high-altitude deer mice
Hypoxia at high altitudes can constrain the ability of endotherms to maintain sufficient rates of pulmonary O 2 transport to support exercise and...
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The Na+-activated K+ channel Slack contributes to synaptic development and plasticity
Human mutations of the Na + -activated K + channel Slack ( KCNT1 ) are associated with epilepsy and intellectual disability. Accordingly, Slack knockout...
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Neonatal GABAergic transmission primes vestibular gating of output for adult spatial navigation
GABAergic interneurons are poised with the capacity to shape circuit output via inhibitory gating. How early in the development of medial vestibular...
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Dearth period pollen foraging pattern by Apis mellifera L., Apis cerana indica F. and Tetragonula bengalensis C. in lower Gangetic alluvium of West Bengal, India: a comparative study
Bees rely exclusively on pollen and nectar-producing plants for strengthening their colonies and production of honey. In beekee**, dearth period...
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Generation and maintenance of the circularized multimeric IS26-associated translocatable unit encoding multidrug resistance
In gram-negative bacteria, IS 26 often exists in multidrug resistance (MDR) regions, forming a pseudocompound transposon (PCTn) that can be tandemly...
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Diversity in photosynthetic pigments and phytochemical compounds among Iranian populations of Inula helenium L.
Elecampane ( Inula helenium L.) is a valuable medicinal plant that has anticancer, cardioprotective, antibacterial and anti-inflammatory properties.....
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Exploring genetic diversity and ascertaining genetic loci associated with important fruit quality traits in apple (Malus × domestica Borkh.)
Genetic diversity is the primary source of variability in any crop improvement program, and the diverse germplasm of any crop species represents an...
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Frequent genetic defects in the p16/INK4A tumor suppressor in canine cell models of breast cancer and melanoma
The cyclin-dependent kinase inhibitors (CKIs) belong to a group of key cell cycle proteins that regulate important cancer drug targets such as the...
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Omentin-1 drives cardiomyocyte cell cycle arrest and metabolic maturation by interacting with BMP7
Mammalian cardiomyocytes (CMs) undergo maturation during postnatal heart development to meet the increased demands of growth. Here, we found that...
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Sexual dimorphism in the social behaviour of Cntnap2-null mice correlates with disrupted synaptic connectivity and increased microglial activity in the anterior cingulate cortex
A biological understanding of the apparent sex bias in autism is lacking. Here we have identified Cntnap2 KO mice as a model system to help better...
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Thermal plasticity of wing size and wing spot size in Drosophila guttifera
Thermal plasticity of melanin pigmentation patterns in Drosophila species has been studied as a model to investigate developmental mechanisms of...
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Compound heterozygous mutations in a mouse model of Leber congenital amaurosis reveal the role of CCT2 in photoreceptor maintenance
TRiC/CCT is a chaperonin complex required for the folding of cytoplasmic proteins. Although mutations in each subunit of TRiC/CCT are associated with...
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An MDM2 inhibitor achieves synergistic cytotoxic effects with adenoviruses lacking E1B55kDa gene on mesothelioma with the wild-type p53 through augmenting NFI expression
A majority of mesothelioma specimens were defective of p14 and p16 expression due to deletion of the INK4A/ARF region, and the p53 pathway was...
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The early excitatory action of striatal cholinergic-GABAergic microcircuits conditions the subsequent GABA inhibitory shift
Cholinergic interneurons of the striatum play a role in action selection and associative learning by activating local GABAergic inhibitory...
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Efficient engineering of human and mouse primary cells using peptide-assisted genome editing
Simple, efficient and well-tolerated delivery of CRISPR genome editing systems into primary cells remains a major challenge. Here we describe an...
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Pharmacological Treatment of Neonatal and Juvenile Mice to Study Spermatogenesis
The delivery, to newborn and juvenile mice, of drugs and other compounds that manipulate the physiology or cellular/molecular state -e.g., by...
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An open protocol for modeling T Cell Clonotype repertoires using TCRβ CDR3 sequences
T cell receptor repertoires can be profiled using next generation sequencing (NGS) to measure and monitor adaptive dynamical changes in response to...
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Cold-inducible RNA binding protein alleviates iron overload-induced neural ferroptosis under perinatal hypoxia insult
Cold-inducible RNA binding protein (CIRBP), a stress response protein, protects cells from mild hypothermia or hypoxia by stabilizing specific mRNAs...
