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Resistin-like molecules: a marker, mediator and therapeutic target for multiple diseases
Resistin-like molecules (RELMs) are highly cysteine-rich proteins, including RELMα, RELMβ, Resistin, and RELMγ. However, RELMs exhibit significant...
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Function of Mediator in Regulating Salicylic Acid Mediated Signaling and Responses in Plants
Mediator is a transcriptional co-regulator required for the transcription of all protein coding genes by RNA polymerase II (RNA pol II) in eukaryotes...
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APC mutations disrupt β-catenin destruction complex condensates organized by Axin phase separation
The Wnt/β-catenin pathway is critical to maintaining cell fate decisions. Recent study showed that liquid–liquid-phase separation (LLPS) of Axin...
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Zinc as a Mediator Through the ROCK1 Pathway of Cognitive Impairment in Aluminum-Exposed Workers: A Clinical and Animal Study
Aluminum (Al) exposure was implicated in neurodegenerative diseases and cognitive impairment, yet the involvement of zinc (Zn) and its mechanism in...
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LINC complex protein nesprin-2 has pro-apoptotic activity via Bcl-2 family proteins
The apoptotic intrinsic pathway is initiated by perforation of the mitochondrial outer membrane by the effector pro-apoptotic proteins of the Bcl-2...
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Atherogenic Index of Plasma as a Mediator in the association between Body Roundness Index and Depression: insights from NHANES 2005–2018
BackgroundPrevious studies have shown a correlation between depression and obesity, as well as between depression and the Atherogenic Index of Plasma...
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Genome-wide CRISPR screens identify ILF3 as a mediator of mTORC1-dependent amino acid sensing
The mechanistic target of rapamycin complex 1 (mTORC1) is an essential hub that integrates nutrient signals and coordinates metabolism to control...
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Research progress of SWI/SNF complex in breast cancer
In the past decade, numerous epigenetic mechanisms have been discovered to be associated with cancer. The mammalian SWI/SNF complex is an...
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CanB is a metabolic mediator of antibiotic resistance in Neisseria gonorrhoeae
The evolution of the obligate human pathogen Neisseria gonorrhoeae has been shaped by selective pressures from diverse host niche environments and...
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Antimicrobial peptides: a novel and natural approach as antibiofouling mediator
Antimicrobial peptides (AMPs) are natural ribosomal synthesized small peptides and are crucial effectors in all living organisms. AMPs are diverse...
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Keep quiet: the HUSH complex in transcriptional silencing and disease
The human silencing hub (HUSH) complex is an epigenetic repressor complex whose role has emerged as an important guardian of genome integrity. It...
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LimeMap: a comprehensive map of lipid mediator metabolic pathways
Lipid mediators are major factors in multiple biological functions and are strongly associated with disease. Recent lipidomics approaches have made...
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Caspase-8 as a novel mediator linking Src kinase signaling to enhanced glioblastoma malignancy
Caspase-8 is a cysteine protease that plays an essential role in apoptosis. Consistently with its canonical proapoptotic function, cancer cells may...
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Caveolin-1 identified as a key mediator of acute lung injury using bioinformatics and functional research
Acute lung injury (ALI) is a potentially life-threatening, devastating disease with an extremely high rate of mortality. The underlying mechanism of...
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A functional genetic screen identifies the Mediator complex as essential for SSX2-induced senescence
The senescence response to oncogenes is believed to be a barrier to oncogenic transformation in premalignant lesions, and describing the mechanisms...
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Structures of transcription preinitiation complex engaged with the +1 nucleosome
The preinitiation complex (PIC) assembles on promoters of protein-coding genes to position RNA polymerase II (Pol II) for transcription initiation....
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Jagged1 intracellular domain/SMAD3 complex transcriptionally regulates TWIST1 to drive glioma invasion
Jagged1 (JAG1) is a Notch ligand that correlates with tumor progression. Not limited to its function as a ligand, JAG1 can be cleaved, and its...
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Transmembrane adaptor protein PAG is a mediator of PD-1 inhibitory signaling in human T cells
The inhibitory receptor PD-1 is expressed on T cells to inhibit select functions when ligated. The complete signaling mechanism downstream of PD-1...
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The BRCA1/BARD1 complex recognizes pre-ribosomal RNA to facilitate homologous recombination
The BRCA1/BARD1 complex plays a key role in the repair of DNA double-strand breaks (DSBs) in both somatic cells and germ cells. However, the...
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Genomic regulation of transcription and RNA processing by the multitasking Integrator complex
In higher eukaryotes, fine-tuned activation of protein-coding genes and many non-coding RNAs pivots around the regulated activity of RNA polymerase...
